Lifespan changes: From wild type to age-1;ogt-1

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Genetic mutants with age-1, ogt-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C


  • Diet

    NGM; OP50

  • Lifespan (days)


  • Phenotype

    Lifespan of age-1(hx546) mutants is dependent on protein O-GlcNAc modification as seen in age-1; ogt-1 double mutants.

  • Lifespan comparisons

    Double mutant age-1(hx546);ogt-1(ok1474) has a lifespan of 15.9 days, while single mutant age-1(hx546) has a lifespan of 25.6 days, single mutant ogt-1(ok1474) has a lifespan of 12.9 days and wild type has a lifespan of 15.9 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Rahman MM et al., 2010, Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans. Aging (Albany NY). 2(10):678-90 PubMed 20952811 Click here to select all mutants from this PubMed ID in the graph

Search genes: age-1 ogt-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Phosphatidylinositol 3-kinase age-1;hypothetical protein

Locus: CELE_B0334.8

Wormbase description: age-1 encodes the C. elegans ortholog of the phosphoinositide 3-kinase (PI3K) p110 catalytic subunit; AGE-1, supplied maternally and embryonically, is a central component of the C. elegans insulin-like signaling pathway, lying downstream of the DAF-2/insulin receptor and upstream of both the PDK-1 and AKT-1/AKT-2 kinases and the DAF-16 forkhead type transcription factor, whose negative regulation is the key output of the insulin signaling pathway; in accordance with its role in insulin signaling, AGE-1 activity is required for regulation of metabolism, life span, dauer formation, stress resistance, salt chemotaxis learning, fertility, and embryonic development; although the age-1 expression pattern has not yet been reported, ectopic expression studies indicate that pan-neuronal age-1 expression is sufficient to rescue life-span defects, while neuronal, intestinal, or muscle expression can partially rescue dauer formation, and neuronal or muscle expression can rescue metabolic defects.

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

O-linked GlcNAc Transferase;UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase

Locus: CELE_K04G7.3

Wormbase description: ogt-1 encodes an ortholog of O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT; OMIM:300255) with 12 N-terminal tetratricopeptide (TPR) domains (generally thought to enable protein-protein interactions) and a C-terminal putative catalytic domain; although loss of ogt-1 activity has no effect on overall viability or fertility, ogt-1 mutations result in alterations in macronutrient storage and can suppress constitutive dauer formation in daf-2 mutants suggesting that, in C. elegans, ogt-1 may play a regulatory role in nutrient sensing and insulin-like signaling pathways; OGT-1 is expressed in embryos, where it exhibits nuclear and punctate perinuclear localization.

Orthologs of age-1;ogt-1 in SynergyAge
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Species Gene
Orthologs of age-1 in SynergyAge
Show in SynergyAge
Species Gene
Drosophila melanogaster Pi3K92E
Orthologs of ogt-1 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: