Lifespan changes: From wild type to daf-2;lipl-4
20
NGM
28.61
54.82%
lipl-4 RNAi partially suppressed the longevity of daf-2 mutants. These results suggest that lipid hydrolysis is also connected to life-span control in the daf-2 long-lived animals.
Double mutant daf-2(e1370);lipl-4(RNAi) has a lifespan of 28.61 days, while single mutant lipl-4(RNAi) has a lifespan of 18.57 days, single mutant daf-2(e1370) has a lifespan of 37.39 days and wild type has a lifespan of 18.48 days.
Dependent
Wang MC et al., 2008, Fat metabolism links germline stem cells and longevity in C. elegans. Science. 322(5903):957-60 
18988854
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Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein
Locus: CELE_Y55D5A.5
Wormbase description: daf-2 encodes a receptor tyrosine kinase that is the C. elegans insulin/IGF receptor ortholog; DAF-2 activity is required for a number of processes in C. elegans, including embryonic and larval development, formation of the developmentally arrested dauer larval stage (diapause), larval developmental timing, adult longevity, reproduction, fat storage, salt chemotaxis learning, and stress resistance, including response to high temperature, oxidative stress, and bacterial infection; DAF-2 signals through a conserved PI 3-kinase pathway to negatively regulate the activity of DAF-16, a Forkhead-related transcription factor, by inducing its phosphorylation and nuclear exclusion; in addition, DAF-2 negatively regulates the nuclear localization, and hence transcriptional activity, of SKN-1 in intestinal nuclei; amongst the 38 predicted insulin-like molecules in C. elegans, genetic and microarray analyses suggest that at least DAF-28, INS-1, and INS-7 are likely DAF-2 ligands; genetic mosaic and tissue-specific promoter studies indicate that daf-2 can function cell nonautonomously and within multiple cell types to influence dauer formation and adult lifespan, likely by regulating the production of secondary endocrine signals that coordinate growth and longevity throughout the animal; temporal analysis of daf-2 function indicates that daf-2 regulates lifespan, reproduction, and diapause independently, at distinct times during the animal's life cycle.
LIPase Like;Lipase
Locus: CELE_K04A8.5
Wormbase description: lipl-4 encodes a triglyceride lipase; by homology, LIPL-4 is predicted to function in lipid hydrolysis; genetic studies indicate that lipl-4 functions as part of an endocrine signaling pathway that coordinates reproductive status, fat metabolism, and longevity; in response to reduced insulin signaling or germline removal (glp-1 mutant animals), lipl-4 expression is induced in the intestine, in a DAF-16-dependent manner; overexpression of lipl-4 can extend lifespan, in a manner dependent upon autophagy genes, such as bec-1, vps-34, and lgg-1.
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| Drosophila melanogaster | InR |
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
