Lifespan changes: From wild type to cul-4;daf-2
25
26.2
40.86%
Inactivating regulatory proteasomal function by RNAi-knockdown of the six predicted worm Cullins, CUL-1 to -6 , had distinct effects on the extended lifespan of daf-2(mu150) mutants. Some knockdowns suppressed lifespan extension (cul-1, cul-3), some had less significant effects (cul-4), and others had no effect at all (cul-5)
Double mutant cul-4(RNAi);daf-2(mu150) has a lifespan of 26.2 days, while single mutant daf-2(mu150) has a lifespan of 28.8 days, single mutant cul-4(RNAi) has a lifespan of 19.7 days and wild type has a lifespan of 18.6 days.
Dependent
Ghazi A et al., 2007, Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex. Proc Natl Acad Sci U S A. 104(14):5947-52 
17392428
Click here to select all mutants from this PubMed ID in the graph
Cullin-4
Locus: CELE_F45E12.3
Wormbase description: cul-4 encodes one of six C. elegans cullin proteins; CUL-4 activity is essential for negative regulation of DNA-replication licensing and thus, for maintenance of genome stability; in regulating DNA replication, CUL-4 functions as part of a CUL-4/DDB-1 ubiquitin ligase complex that degrades the replication licensing factor CDT-1 and indirectly promotes nuclear export of the replication licensing factor CDC-6 by negatively regulating the levels of the CKI-1 CDK inhibitor; cul-4 mRNA is expressed throughout development with highest levels seen in embryos and lower levels seen in larvae and adults; maternal cul-4 mRNA is present in early embryos and larval and adult mRNA is most notably present in the intestine and germ line.
Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein
Locus: CELE_Y55D5A.5
Wormbase description: daf-2 encodes a receptor tyrosine kinase that is the C. elegans insulin/IGF receptor ortholog; DAF-2 activity is required for a number of processes in C. elegans, including embryonic and larval development, formation of the developmentally arrested dauer larval stage (diapause), larval developmental timing, adult longevity, reproduction, fat storage, salt chemotaxis learning, and stress resistance, including response to high temperature, oxidative stress, and bacterial infection; DAF-2 signals through a conserved PI 3-kinase pathway to negatively regulate the activity of DAF-16, a Forkhead-related transcription factor, by inducing its phosphorylation and nuclear exclusion; in addition, DAF-2 negatively regulates the nuclear localization, and hence transcriptional activity, of SKN-1 in intestinal nuclei; amongst the 38 predicted insulin-like molecules in C. elegans, genetic and microarray analyses suggest that at least DAF-28, INS-1, and INS-7 are likely DAF-2 ligands; genetic mosaic and tissue-specific promoter studies indicate that daf-2 can function cell nonautonomously and within multiple cell types to influence dauer formation and adult lifespan, likely by regulating the production of secondary endocrine signals that coordinate growth and longevity throughout the animal; temporal analysis of daf-2 function indicates that daf-2 regulates lifespan, reproduction, and diapause independently, at distinct times during the animal's life cycle.
| Show in SynergyAge | |
|---|---|
| Species | Gene |
| Show in SynergyAge | |
|---|---|
| Species | Gene |
| Show in SynergyAge | |
|---|---|
| Species | Gene |
| Drosophila melanogaster | InR |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
