Lifespan changes: From wild type to age-1;fer-15;gro-1

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Genetic mutants with age-1, fer-15, gro-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C


  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Lifespan comparisons

    Triple mutant age-1(hx546);fer-15(b26);gro-1(e2400) has a lifespan of 34.1 days, while single mutant gro-1(e2400) has a lifespan of 19.2 days, double mutant age-1(hx546);fer-15(b26) has a lifespan of 26.3 days and wild type has a lifespan of 14.9 days.

  • Citation
    View abstract

    Lakowski B, Hekimi S, 1996, Determination of life-span in Caenorhabditis elegans by four clock genes. Science. 272(5264):1010-3 PubMed 8638122 Click here to select all mutants from this PubMed ID in the graph

Search genes: age-1 fer-15 gro-1 age-1;fer-15;gro-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Phosphatidylinositol 3-kinase age-1;hypothetical protein

Locus: CELE_B0334.8

Wormbase description: age-1 encodes the C. elegans ortholog of the phosphoinositide 3-kinase (PI3K) p110 catalytic subunit; AGE-1, supplied maternally and embryonically, is a central component of the C. elegans insulin-like signaling pathway, lying downstream of the DAF-2/insulin receptor and upstream of both the PDK-1 and AKT-1/AKT-2 kinases and the DAF-16 forkhead type transcription factor, whose negative regulation is the key output of the insulin signaling pathway; in accordance with its role in insulin signaling, AGE-1 activity is required for regulation of metabolism, life span, dauer formation, stress resistance, salt chemotaxis learning, fertility, and embryonic development; although the age-1 expression pattern has not yet been reported, ectopic expression studies indicate that pan-neuronal age-1 expression is sufficient to rescue life-span defects, while neuronal, intestinal, or muscle expression can partially rescue dauer formation, and neuronal or muscle expression can rescue metabolic defects.

  • Symbol
  • GenAge

No gene information for fer-15

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

hypothetical protein

Locus: CELE_ZC395.6

Wormbase description: gro-1 encodes two isoforms of the C. elegans isopentenylpyroptiosphate:tRNA transferase (IPT) ortholog; by homology, GRO-1 is predicted to function in modification of a subset of tRNAs; in C. elegans, a loss-of-function mutation in gro-1 results in delayed embryogenesis and postembryonic development, slower rates of adult behaviors, reduced brood size, and a genetic background-specific increase in adult life span; gro-1's effect on embryonic development exhibits a strict maternal effect; GRO-1::GFP fusion proteins are widely expressed and localize to the cytoplasm, nucleus, and mitochondria.

Orthologs of age-1;fer-15;gro-1 in SynergyAge
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Species Gene
Orthologs of age-1 in SynergyAge
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Species Gene
Drosophila melanogaster Pi3K92E
Orthologs of fer-15 in SynergyAge
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Species Gene
Orthologs of gro-1 in SynergyAge
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Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: