age-1;daf-16

Lifespan changes: From wild type to age-1;daf-16

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Genetic mutants with age-1, daf-16 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    HT115; OP51

  • Lifespan (days)

    17.9

  • Lifespan change (compared to wild type)

    -22.84%

  • Phenotype

    Down-regulation of daf-16 in adulthood suppressed longevity of age-1(hx546) animals.

  • Lifespan comparisons

    Double mutant age-1(hx546);daf-16(RNAi) has a lifespan of 17.9 days, while single mutant daf-16(RNAi) has a lifespan of 16.9 days, single mutant age-1(hx546) has a lifespan of 32.1 days and wild type has a lifespan of 23.2 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Morley JF, Morimoto RI, 2004, Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol Biol Cell. 15(2):657-64 PubMed 14668486 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Lifespan (days)

    13.24

  • Lifespan change (compared to wild type)

    -31.08%

  • Phenotype

    daf-16 RNAi completely abolished the synergistic effect of drp-1 and daf-2/age-1 mutations.

  • Lifespan comparisons

    Double mutant age-1(hx546);daf-16(RNAi) has a lifespan of 13.24 days, while single mutant daf-16(RNAi) has a lifespan of 12.65 days and wild type has a lifespan of 19.21 days.

  • Type of interaction
    See methods

    Contains dependence

  • Citation
    View abstract

    Yang CC et al., 2011, The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity. Aging Cell. 10(4):724-8 PubMed 21463460 Click here to select all mutants from this PubMed ID in the graph

Search genes: age-1 daf-16
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Phosphatidylinositol 3-kinase age-1;hypothetical protein


Locus: CELE_B0334.8


Wormbase description: age-1 encodes the C. elegans ortholog of the phosphoinositide 3-kinase (PI3K) p110 catalytic subunit; AGE-1, supplied maternally and embryonically, is a central component of the C. elegans insulin-like signaling pathway, lying downstream of the DAF-2/insulin receptor and upstream of both the PDK-1 and AKT-1/AKT-2 kinases and the DAF-16 forkhead type transcription factor, whose negative regulation is the key output of the insulin signaling pathway; in accordance with its role in insulin signaling, AGE-1 activity is required for regulation of metabolism, life span, dauer formation, stress resistance, salt chemotaxis learning, fertility, and embryonic development; although the age-1 expression pattern has not yet been reported, ectopic expression studies indicate that pan-neuronal age-1 expression is sufficient to rescue life-span defects, while neuronal, intestinal, or muscle expression can partially rescue dauer formation, and neuronal or muscle expression can rescue metabolic defects.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Forkhead box protein O;hypothetical protein


Locus: CELE_R13H8.1


Wormbase description: daf-16 encodes the sole C. elegans forkhead box O (FOXO) homologue; DAF-16 functions as a transcription factor that acts in the insulin/IGF-1-mediated signaling (IIS) pathway that regulates dauer formation, longevity, fat metabolism, stress response, and innate immunity; DAF-16 regulates these various processes through isoform-specific expression, isoform-specific regulation by different AKT kinases, and differential regulation of target genes; DAF-16 can interact with the CBP-1 transcription cofactor in vitro, and interacts genetically with other genes in the insulin signaling and with daf-12, which encodes a nuclear hormone receptor; DAF-16 is activated in response to DNA damage during development and co-regulated by EGL-27, alleviates DNA-damage-induced developmental arrest by inducing DAF-16-associated element (DAE)-regulated genes; DAF-16 is broadly expressed but displays isoform-specific tissue enrichment; DAF-16 localizes to both the cytoplasm and the nucleus, with the ratio between the two an important regulator of function.


Orthologs of age-1;daf-16 in SynergyAge
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Species Gene
Orthologs of age-1 in SynergyAge
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Species Gene
Drosophila melanogaster Pi3K92E
Orthologs of daf-16 in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group