age-1;drp-1

Lifespan changes: From wild type to age-1;drp-1

There is no network for this step.
Fullscreen mode
Hide graph
Legend

Genetic mutants with age-1, drp-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Lifespan (days)

    40.72

  • Lifespan change (compared to wild type)

    111.97%

  • Phenotype

    The extended longevity and the sensitivity to heat stress of the age1;drp-1 mutant compared to the age-1 mutant can be rescued by introduction of a transgene overexpressing drp-1. drp-1 RNAi affects mitochondrial morphology in muscle cells of the body wall. Both age-1 and daf-2 mutants treated with drp-1 RNAi showed substantial further increase in mean lifespan (>65% compared to age-1 and daf-2 single mutant on control RNAi).

  • Lifespan comparisons

    Double mutant age-1(hx546);drp-1(RNAi) has a lifespan of 40.72 days, while single mutant drp-1(RNAi) has a lifespan of 19.27 days, single mutant age-1(hx546) has a lifespan of 26.89 days and wild type has a lifespan of 19.21 days.

  • Type of interaction
    See methods

    Synergistic (positive)

  • Citation
    View abstract

    Yang CC et al., 2011, The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity. Aging Cell. 10(4):724-8 PubMed 21463460 Click here to select all mutants from this PubMed ID in the graph

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Lifespan (days)

    33.49

  • Lifespan change (compared to wild type)

    121.06%

  • Phenotype

    age-1;drp-1 and daf-2;drp-1 mutants exhibited a >75% increase in mean lifespan and an extension by up to 30 days in maximum lifespan when compared to their single mutant counterparts.

  • Lifespan comparisons

    Double mutant age-1(hx546);drp-1(tm1108) has a lifespan of 33.49 days, while single mutant age-1(hx546) has a lifespan of 26.87 days, single mutant drp-1(tm1108) has a lifespan of 15.44 days and wild type has a lifespan of 15.15 days.

  • Type of interaction
    See methods

    Synergistic (positive)

  • Citation
    View abstract

    Yang CC et al., 2011, The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity. Aging Cell. 10(4):724-8 PubMed 21463460 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Lifespan (days)

    37.76

  • Lifespan change (compared to wild type)

    149.24%

  • Phenotype

    age-1;drp-1 and daf-2;drp-1 mutants exhibited a >75% increase in mean lifespan and an extension by up to 30 days in maximum lifespan when compared to their single mutant counterparts.

  • Lifespan comparisons

    Double mutant age-1(hx546);drp-1(tm1108) has a lifespan of 37.76 days, while single mutant drp-1(tm1108) has a lifespan of 15.44 days, single mutant age-1(hx546) has a lifespan of 26.87 days and wild type has a lifespan of 15.15 days.

  • Type of interaction
    See methods

    Synergistic (positive)

  • Citation
    View abstract

    Yang CC et al., 2011, The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity. Aging Cell. 10(4):724-8 PubMed 21463460 Click here to select all mutants from this PubMed ID in the graph

Search genes: age-1 drp-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Phosphatidylinositol 3-kinase age-1;hypothetical protein


Locus: CELE_B0334.8


Wormbase description: age-1 encodes the C. elegans ortholog of the phosphoinositide 3-kinase (PI3K) p110 catalytic subunit; AGE-1, supplied maternally and embryonically, is a central component of the C. elegans insulin-like signaling pathway, lying downstream of the DAF-2/insulin receptor and upstream of both the PDK-1 and AKT-1/AKT-2 kinases and the DAF-16 forkhead type transcription factor, whose negative regulation is the key output of the insulin signaling pathway; in accordance with its role in insulin signaling, AGE-1 activity is required for regulation of metabolism, life span, dauer formation, stress resistance, salt chemotaxis learning, fertility, and embryonic development; although the age-1 expression pattern has not yet been reported, ectopic expression studies indicate that pan-neuronal age-1 expression is sufficient to rescue life-span defects, while neuronal, intestinal, or muscle expression can partially rescue dauer formation, and neuronal or muscle expression can rescue metabolic defects.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Dynamin-Related Protein


Locus: CELE_T12E12.4


Wormbase description: drp-1 encodes a dynamin-related protein, orthologous to Dnm1p in S. cerevisiae and DRP1 in mammals, that is required for severing of the mitochondrial outer membrane during mitochondrial division.


Orthologs of age-1;drp-1 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of age-1 in SynergyAge
Show in SynergyAge
Species Gene
Drosophila melanogaster Pi3K92E
Orthologs of drp-1 in SynergyAge
Show in SynergyAge
Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group