age-1;drp-1

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Genetic mutants with age-1, drp-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
40.72
Lifespan change (compared to wild type)
111.97%
Phenotype
The extended longevity and the sensitivity to heat stress of the age1;drp-1 mutant compared to the age-1 mutant can be rescued by introduction of a transgene overexpressing drp-1. drp-1 RNAi affects mitochondrial morphology in muscle cells of the body wall. Both age-1 and daf-2 mutants treated with drp-1 RNAi showed substantial further increase in mean lifespan (>65% compared to age-1 and daf-2 single mutant on control RNAi).
Lifespan comparisons
Double mutant age-1(hx546);drp-1(RNAi) has a lifespan of 40.72 days, while single mutant drp-1(RNAi) has a lifespan of 19.27 days, single mutant age-1(hx546) has a lifespan of 26.89 days and wild type has a lifespan of 19.21 days.
Type of interaction
See methods
Synergistic (positive)
Citation
View abstract
Yang CC et al., 2011, The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity. Aging Cell. 10(4):724-8 21463460 Click here to select all mutants from this PubMed ID in the graph
Abstract
Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging.

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
33.49
Lifespan change (compared to wild type)
121.06%
Phenotype
age-1;drp-1 and daf-2;drp-1 mutants exhibited a >75% increase in mean lifespan and an extension by up to 30 days in maximum lifespan when compared to their single mutant counterparts.
Lifespan comparisons
Double mutant age-1(hx546);drp-1(tm1108) has a lifespan of 33.49 days, while single mutant age-1(hx546) has a lifespan of 26.87 days, single mutant drp-1(tm1108) has a lifespan of 15.44 days and wild type has a lifespan of 15.15 days.
Type of interaction
See methods
Synergistic (positive)
Citation
View abstract
Yang CC et al., 2011, The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity. Aging Cell. 10(4):724-8 21463460 Click here to select all mutants from this PubMed ID in the graph
Abstract
Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging.

Temperature °C
20
Lifespan (days)
37.76
Lifespan change (compared to wild type)
149.24%
Phenotype
age-1;drp-1 and daf-2;drp-1 mutants exhibited a >75% increase in mean lifespan and an extension by up to 30 days in maximum lifespan when compared to their single mutant counterparts.
Lifespan comparisons
Double mutant age-1(hx546);drp-1(tm1108) has a lifespan of 37.76 days, while single mutant drp-1(tm1108) has a lifespan of 15.44 days, single mutant age-1(hx546) has a lifespan of 26.87 days and wild type has a lifespan of 15.15 days.
Type of interaction
See methods
Synergistic (positive)
Citation
View abstract
Yang CC et al., 2011, The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity. Aging Cell. 10(4):724-8 21463460 Click here to select all mutants from this PubMed ID in the graph
Abstract
Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging.

Search genes: age-1 drp-1

Entrez ID
Symbol
GenAge
Wormbase ID

174762
age-1
View on GenAge (age-1)
WBGene00000090

Phosphatidylinositol 3-kinase age-1;hypothetical protein

Locus: CELE_B0334.8

Wormbase description: age-1 encodes the C. elegans ortholog of the phosphoinositide 3-kinase (PI3K) p110 catalytic subunit; AGE-1, supplied maternally and embryonically, is a central component of the C. elegans insulin-like signaling pathway, lying downstream of the DAF-2/insulin receptor and upstream of both the PDK-1 and AKT-1/AKT-2 kinases and the DAF-16 forkhead type transcription factor, whose negative regulation is the key output of the insulin signaling pathway; in accordance with its role in insulin signaling, AGE-1 activity is required for regulation of metabolism, life span, dauer formation, stress resistance, salt chemotaxis learning, fertility, and embryonic development; although the age-1 expression pattern has not yet been reported, ectopic expression studies indicate that pan-neuronal age-1 expression is sufficient to rescue life-span defects, while neuronal, intestinal, or muscle expression can partially rescue dauer formation, and neuronal or muscle expression can rescue metabolic defects.

Entrez ID
Symbol
GenAge
Wormbase ID

177336
drp-1
View on GenAge (drp-1)
WBGene00001093

Dynamin-Related Protein

Locus: CELE_T12E12.4

Wormbase description: drp-1 encodes a dynamin-related protein, orthologous to Dnm1p in S. cerevisiae and DRP1 in mammals, that is required for severing of the mitochondrial outer membrane during mitochondrial division.

Orthologs of age-1;drp-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Drp1;Pi3K92E
Mus musculus	Dnm1l;Pik3cd
Mus musculus	Dnm1l;Pik3ca
Mus musculus	Dnm1l;Pik3cb
Mus musculus	Dnm1l;Pik3cg

Orthologs of age-1 in SynergyAge

Show in SynergyAge
Species	Gene
Drosophila melanogaster	Pi3K92E

Not in SynergyAge
Species	Gene
Mus musculus	Pik3cd
Mus musculus	Pik3ca
Mus musculus	Pik3cb
Mus musculus	Pik3cg

Orthologs of drp-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Drp1
Mus musculus	Dnm1l