daf-2;tub-1

Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein

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Locus: CELE_Y55D5A.5

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Wormbase description: daf-2 encodes a receptor tyrosine kinase that is the C. elegans insulin/IGF receptor ortholog; DAF-2 activity is required for a number of processes in C. elegans, including embryonic and larval development, formation of the developmentally arrested dauer larval stage (diapause), larval developmental timing, adult longevity, reproduction, fat storage, salt chemotaxis learning, and stress resistance, including response to high temperature, oxidative stress, and bacterial infection; DAF-2 signals through a conserved PI 3-kinase pathway to negatively regulate the activity of DAF-16, a Forkhead-related transcription factor, by inducing its phosphorylation and nuclear exclusion; in addition, DAF-2 negatively regulates the nuclear localization, and hence transcriptional activity, of SKN-1 in intestinal nuclei; amongst the 38 predicted insulin-like molecules in C. elegans, genetic and microarray analyses suggest that at least DAF-28, INS-1, and INS-7 are likely DAF-2 ligands; genetic mosaic and tissue-specific promoter studies indicate that daf-2 can function cell nonautonomously and within multiple cell types to influence dauer formation and adult lifespan, likely by regulating the production of secondary endocrine signals that coordinate growth and longevity throughout the animal; temporal analysis of daf-2 function indicates that daf-2 regulates lifespan, reproduction, and diapause independently, at distinct times during the animal's life cycle.

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Tubby protein homolog 1

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Locus: CELE_F10B5.4

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Wormbase description: tub-1 encodes a TUBBY homolog that affects fat storage across species including C. elegans; tub-1 functions with kat-1, a 3-ketoacyl-coA thiolase, to affect lipid accumulation; tub-1 is also required for normal life span as tub-1 mutants show extended life span which is dependent on daf-16/FOXO3a; tub-1 interacts with a novel RabGTPase-activating protein RBG-3 and upregulates the activity of a small GTPase, RAB-7, suggesting the involvement of an endocytic pathway in regulating fat storage; tub-1 is expressed in ciliated neurons where its activity is required for proper localization of G protein-coupled receptors to nonmotile primary cilia; tub-1 localizes predominantly to the cytoplasm, but undergoes transport supporting its involvement in neuronal trafficking and chemosensation.

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