age-1;daf-2;fer-15

Lifespan changes: From wild type to age-1;daf-2;fer-15

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Genetic mutants with age-1, daf-2, fer-15 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    25

  • Diet

    OP50

  • Lifespan (days)

    29.0

  • Lifespan change (compared to wild type)

    107.14%

  • Lifespan comparisons

    Triple mutant age-1(hx546);daf-2(e1370);fer-15(b26) has a lifespan of 29.0 days, while single mutant daf-2(e1370) has a lifespan of 35.0 days, double mutant age-1(hx546);fer-15(b26) has a lifespan of 23.0 days and wild type has a lifespan of 14.0 days.

  • Citation
    View abstract

    Dorman JB et al., 1995, The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics. 141(4):1399-406 PubMed 8601482 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    15

  • Diet

    OP50

  • Lifespan (days)

    49.0

  • Lifespan change (compared to wild type)

    96.00%

  • Lifespan comparisons

    Triple mutant age-1(hx546);daf-2(e1370);fer-15(b26) has a lifespan of 49.0 days, while single mutant daf-2(e1370) has a lifespan of 43.0 days, double mutant age-1(hx546);fer-15(b26) has a lifespan of 31.0 days and wild type has a lifespan of 25.0 days.

  • Citation
    View abstract

    Dorman JB et al., 1995, The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics. 141(4):1399-406 PubMed 8601482 Click here to select all mutants from this PubMed ID in the graph

Search genes: age-1 daf-2 fer-15 age-1;daf-2;fer-15
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Phosphatidylinositol 3-kinase age-1;hypothetical protein


Locus: CELE_B0334.8


Wormbase description: age-1 encodes the C. elegans ortholog of the phosphoinositide 3-kinase (PI3K) p110 catalytic subunit; AGE-1, supplied maternally and embryonically, is a central component of the C. elegans insulin-like signaling pathway, lying downstream of the DAF-2/insulin receptor and upstream of both the PDK-1 and AKT-1/AKT-2 kinases and the DAF-16 forkhead type transcription factor, whose negative regulation is the key output of the insulin signaling pathway; in accordance with its role in insulin signaling, AGE-1 activity is required for regulation of metabolism, life span, dauer formation, stress resistance, salt chemotaxis learning, fertility, and embryonic development; although the age-1 expression pattern has not yet been reported, ectopic expression studies indicate that pan-neuronal age-1 expression is sufficient to rescue life-span defects, while neuronal, intestinal, or muscle expression can partially rescue dauer formation, and neuronal or muscle expression can rescue metabolic defects.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein


Locus: CELE_Y55D5A.5


Wormbase description: daf-2 encodes a receptor tyrosine kinase that is the C. elegans insulin/IGF receptor ortholog; DAF-2 activity is required for a number of processes in C. elegans, including embryonic and larval development, formation of the developmentally arrested dauer larval stage (diapause), larval developmental timing, adult longevity, reproduction, fat storage, salt chemotaxis learning, and stress resistance, including response to high temperature, oxidative stress, and bacterial infection; DAF-2 signals through a conserved PI 3-kinase pathway to negatively regulate the activity of DAF-16, a Forkhead-related transcription factor, by inducing its phosphorylation and nuclear exclusion; in addition, DAF-2 negatively regulates the nuclear localization, and hence transcriptional activity, of SKN-1 in intestinal nuclei; amongst the 38 predicted insulin-like molecules in C. elegans, genetic and microarray analyses suggest that at least DAF-28, INS-1, and INS-7 are likely DAF-2 ligands; genetic mosaic and tissue-specific promoter studies indicate that daf-2 can function cell nonautonomously and within multiple cell types to influence dauer formation and adult lifespan, likely by regulating the production of secondary endocrine signals that coordinate growth and longevity throughout the animal; temporal analysis of daf-2 function indicates that daf-2 regulates lifespan, reproduction, and diapause independently, at distinct times during the animal's life cycle.


  • Symbol
  • GenAge

No gene information for fer-15


Orthologs of age-1;daf-2;fer-15 in SynergyAge
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Species Gene
Orthologs of age-1 in SynergyAge
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Species Gene
Drosophila melanogaster Pi3K92E
Orthologs of daf-2 in SynergyAge
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Species Gene
Drosophila melanogaster InR
Orthologs of fer-15 in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group