| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| daf-16;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 24 | -31.97% | ||
| daf-16;daf-16;glp-1 | Caenorhabditis elegans | Triple mutant | 14 | -57.37% .. -232.71% | [est.] | |
| daf-16;daf-18 | Caenorhabditis elegans | Double mutant | 1 | -19.67% | ||
| daf-16;daf-19 | Caenorhabditis elegans | Double mutant | 1 | -18.62% | ||
| daf-16;daf-2 | Caenorhabditis elegans | Double mutant | 95 | -41.38% .. 34.43% | ||
| daf-16;daf-23 | Caenorhabditis elegans | Double mutant | 1 | -65.2% .. 41.18% | [est.] | |
| daf-16;daf-28 | Caenorhabditis elegans | Double mutant | 1 | -32.37% | ||
| daf-16;daf-2;drp-1 | Caenorhabditis elegans | Triple mutant | 1 | -14.94% | ||
| daf-16;daf-2;egr-1 | Caenorhabditis elegans | Triple mutant | 1 | -49.66% | ||
| daf-16;daf-2;elo-5 | Caenorhabditis elegans | Triple mutant | 1 | -36.73% | ||
| daf-16;daf-2;F14B4.3 | Caenorhabditis elegans | Triple mutant | 1 | -35.96% | ||
| daf-16;daf-2;F22D6.3 | Caenorhabditis elegans | Triple mutant | 1 | -35.96% | ||
| daf-16;daf-2;F26E4.4 | Caenorhabditis elegans | Triple mutant | 1 | -35.96% | ||
| daf-16;daf-2;F28D1.9 | Caenorhabditis elegans | Triple mutant | 1 | -36.73% | ||
| daf-16;daf-2;F30A10.10 | Caenorhabditis elegans | Triple mutant | 1 | -45.58% | ||
| daf-16;daf-2;F30A10.6 | Caenorhabditis elegans | Triple mutant | 1 | -36.05% | ||
| daf-16;daf-2;F33H2.8 | Caenorhabditis elegans | Triple mutant | 1 | -44.90% | ||
| daf-16;daf-2;F37C4.4 | Caenorhabditis elegans | Triple mutant | 1 | -40.82% | ||
| daf-16;daf-2;F40F12.7 | Caenorhabditis elegans | Triple mutant | 1 | -30.61% | ||
| daf-16;daf-2;F43D2.1 | Caenorhabditis elegans | Triple mutant | 1 | -56.46% | ||
| daf-16;daf-2;F52C6.2 | Caenorhabditis elegans | Triple mutant | 1 | -29.25% | ||
| daf-16;daf-2;F55B12.4 | Caenorhabditis elegans | Triple mutant | 1 | -42.86% | ||
| daf-16;daf-2;F59A3.3 | Caenorhabditis elegans | Triple mutant | 1 | -33.50% | ||
| daf-16;daf-2;F59C6.4 | Caenorhabditis elegans | Triple mutant | 1 | -33.00% | ||
| daf-16;daf-2;F59C6.5 | Caenorhabditis elegans | Triple mutant | 1 | -35.47% | ||
| daf-16;daf-2;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 9 | -66.65% .. -270.35% | [est.] | |
| daf-16;daf-2;gdi-1 | Caenorhabditis elegans | Triple mutant | 1 | -36.05% | ||
| daf-16;daf-2;glf-1 | Caenorhabditis elegans | Triple mutant | 1 | -55.78% | ||
| daf-16;daf-2;H27M09.1 | Caenorhabditis elegans | Triple mutant | 1 | -38.10% | ||
| daf-16;daf-2;his-71 | Caenorhabditis elegans | Triple mutant | 1 | -31.97% | ||
| daf-16;daf-2;hpk-1 | Caenorhabditis elegans | Triple mutant | 1 | -37.41% | ||
| daf-16;daf-2;hsf-1 | Caenorhabditis elegans | Triple mutant | 1 | -63.27% | ||
| daf-16;daf-2;K01C8.6 | Caenorhabditis elegans | Triple mutant | 1 | -33.99% | ||
| daf-16;daf-2;K11B4.1 | Caenorhabditis elegans | Triple mutant | 1 | -34.98% | ||
| daf-16;daf-2;K11D12.9 | Caenorhabditis elegans | Triple mutant | 1 | -30.61% | ||
| daf-16;daf-2;let-653 | Caenorhabditis elegans | Triple mutant | 1 | -36.73% | ||
| daf-16;daf-2;lmn-1 | Caenorhabditis elegans | Triple mutant | 1 | -41.50% | ||
| daf-16;daf-2;lsm-4 | Caenorhabditis elegans | Triple mutant | 1 | -41.50% | ||
| daf-16;daf-2;lsm-7 | Caenorhabditis elegans | Triple mutant | 1 | -39.46% | ||
| daf-16;daf-2;M03F4.7 | Caenorhabditis elegans | Triple mutant | 1 | -43.54% | ||
| daf-16;daf-2;M05B5.2 | Caenorhabditis elegans | Triple mutant | 1 | -62.59% | ||
| daf-16;daf-2;M57.2 | Caenorhabditis elegans | Triple mutant | 1 | -38.10% | ||
| daf-16;daf-2;mag-1 | Caenorhabditis elegans | Triple mutant | 1 | -36.73% | ||
| daf-16;daf-2;mcm-2 | Caenorhabditis elegans | Triple mutant | 1 | -31.29% | ||
| daf-16;daf-2;mdh-1 | Caenorhabditis elegans | Triple mutant | 1 | -34.01% | ||
| daf-16;daf-2;mep-1 | Caenorhabditis elegans | Triple mutant | 1 | -42.86% | ||
| daf-16;daf-2;mxl-2 | Caenorhabditis elegans | Triple mutant | 1 | -51.70% | ||
| daf-16;daf-2;npp-2 | Caenorhabditis elegans | Triple mutant | 1 | -47.62% | ||
| daf-16;daf-2;npp-3 | Caenorhabditis elegans | Triple mutant | 1 | -40.82% | ||
| daf-16;daf-2;nsh-1 | Caenorhabditis elegans | Triple mutant | 1 | -48.30% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group