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All mutants (1833 results, without single mutants) Organism Mutant type No. experiments Change in average lifespan Epistasis
raga-1;rsks-1 Caenorhabditis elegans Double mutant 2 -40.55% .. -164.47% [est.]
raga-1;skn-1 Caenorhabditis elegans Double mutant 6 -12.16% .. -2.38%  
ragc-1;rde-1 Caenorhabditis elegans Double mutant 3 -0.79%  
ragc-1;skn-1 Caenorhabditis elegans Double mutant 3 -15.61% .. -4.68%  
rbg-3;tub-1 Caenorhabditis elegans Double mutant 1 20.00%  
Rbm38;Trp53 Mus musculus Double mutant 2 -84.30% .. -42.15%  
Rbp9;Rbp9 Drosophila melanogaster Double mutant 1 -69.33% .. -21.77% [est.]
rheb-1;skn-1 Caenorhabditis elegans Double mutant 3 -21.03% .. -12.44%  
Ripk3;Sod1 Mus musculus Double mutant 2 -83.99% .. -239.78% [est.]
rps-15;rsks-1 Caenorhabditis elegans Double mutant 2 -40.84% .. -165.65% [est.]
rps-15;sir-2.1 Caenorhabditis elegans Double mutant 2 -39.68% .. -160.94% [est.]
rrf-1;utx-1 Caenorhabditis elegans Double mutant 7 -3.01% .. 17.08%  
rrf-1;vang-1 Caenorhabditis elegans Double mutant 1 14.06%  
rrf-3;scl-5 Caenorhabditis elegans Double mutant 1 -33.0% .. 171.76% [est.]
rrf-3;sir-2.1 Caenorhabditis elegans Double mutant 6 -61.51% .. -249.53% [est.]
rrf-3;sir-2.1;T05G5.10 Caenorhabditis elegans Triple mutant 1 -51.54% .. 96.59% [est.]
rrf-3;sir-2.1;T06G6.4 Caenorhabditis elegans Triple mutant 1 -56.64% .. 75.88% [est.]
rrf-3;sir-2.1;T20H4.5 Caenorhabditis elegans Triple mutant 1 -37.82% .. 152.24% [est.]
rrf-3;sir-2.1;W05B2.5 Caenorhabditis elegans Triple mutant 1 -57.71% .. 71.53% [est.]
rrf-3;sir-2.1;Y39F10C.1 Caenorhabditis elegans Triple mutant 1 -52.73% .. 91.76% [est.]
rrf-3;sir-2.1;Y39H10A_224.b Caenorhabditis elegans Triple mutant 1 -56.61% .. 76.0% [est.]
rrf-3;sir-2.1;Y43H11_160.a Caenorhabditis elegans Triple mutant 1 -56.73% .. 75.53% [est.]
rrf-3;sir-2.1;Y46H3C_13.a Caenorhabditis elegans Triple mutant 1 -55.19% .. 81.76% [est.]
rrf-3;sir-2.1;Y50D4A_25.a Caenorhabditis elegans Triple mutant 1 -57.6% .. 72.0% [est.]
rrf-3;sir-2.1;Y54E5A.7 Caenorhabditis elegans Triple mutant 1 -51.71% .. 95.88% [est.]
rrf-3;sir-2.1;Y56A3A.9 Caenorhabditis elegans Triple mutant 1 -52.49% .. 92.71% [est.]
rrf-3;sir-2.1;Y71H2_380.a Caenorhabditis elegans Triple mutant 1 -61.46% .. 56.35% [est.]
rrf-3;sir-2.1;Y75B8A.13 Caenorhabditis elegans Triple mutant 1 -60.32% .. 60.94% [est.]
rrf-3;sir-2.1;Y75B8A.33 Caenorhabditis elegans Triple mutant 1 -57.92% .. 70.71% [est.]
rrf-3;sir-2.1;ZC64.3 Caenorhabditis elegans Triple mutant 1 -56.38% .. 76.94% [est.]
rrf-3;skn-1 Caenorhabditis elegans Double mutant 4 -47.83% .. -0.05%  
rrf-3;skr-12 Caenorhabditis elegans Double mutant 2 -45.19% .. -183.29% [est.]
rrf-3;skr-13 Caenorhabditis elegans Double mutant 2 -43.74% .. -177.41% [est.]
rrf-3;skr-15 Caenorhabditis elegans Double mutant 1 -41.71% .. 136.47% [est.]
rrf-3;skr-17 Caenorhabditis elegans Double mutant 2 -44.61% .. -180.94% [est.]
rrf-3;skr-5 Caenorhabditis elegans Double mutant 2 -47.8% .. -193.88% [est.]
rrf-3;skr-8 Caenorhabditis elegans Double mutant 1 -48.67% .. 108.24% [est.]
rrf-3;T20D4.7 Caenorhabditis elegans Double mutant 1 -26.33% .. 198.82% [est.]
rrf-3;vit-1 Caenorhabditis elegans Double mutant 1 -51.86% .. 95.29% [est.]
rrf-3;vit-2 Caenorhabditis elegans Double mutant 2 -47.22% .. -191.53% [est.]
rrf-3;vit-5 Caenorhabditis elegans Double mutant 2 -52.15% .. -211.53% [est.]
rrf-3;Y39B6A.24 Caenorhabditis elegans Double mutant 1 -25.46% .. 202.35% [est.]
rrf-3;Y43C5A.3 Caenorhabditis elegans Double mutant 1 -37.35% .. 154.12% [est.]
rrf-3;Y50D4B.6 Caenorhabditis elegans Double mutant 2 -30.39% .. -123.29% [est.]
rsks-1;rsks-1 Caenorhabditis elegans Double mutant 2 -40.26% .. -163.29% [est.]
rsks-1;sca-1 Caenorhabditis elegans Double mutant 1 19.70%  
rsks-1;sir-2.1 Caenorhabditis elegans Double mutant 3 -42.58% .. -172.71% [est.]
rsks-1;unc-51 Caenorhabditis elegans Double mutant 1 -35.9% .. 160.0% [est.]
rsks-1;unc-70 Caenorhabditis elegans Double mutant 1 44.83%  
sgk-1;skn-1 Caenorhabditis elegans Double mutant 2 -40.58% .. -34.06%  
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About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group