| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| rrf-3;Y50D4B.6 | Caenorhabditis elegans | Double mutant | 2 | -30.39% .. -123.29% | [est.] | |
| rsks-1;rsks-1 | Caenorhabditis elegans | Double mutant | 2 | -40.26% .. -163.29% | [est.] | |
| rsks-1;sca-1 | Caenorhabditis elegans | Double mutant | 1 | 19.70% | ||
| rsks-1;sir-2.1 | Caenorhabditis elegans | Double mutant | 3 | -42.58% .. -172.71% | [est.] | |
| rsks-1;unc-51 | Caenorhabditis elegans | Double mutant | 1 | -35.9% .. 160.0% | [est.] | |
| rsks-1;unc-70 | Caenorhabditis elegans | Double mutant | 1 | 44.83% | ||
| sgk-1;skn-1 | Caenorhabditis elegans | Double mutant | 2 | -40.58% .. -34.06% | ||
| sgk-1;trpa-1 | Caenorhabditis elegans | Double mutant | 3 | -19.39% .. 22.97% | ||
| sgk-1;utx-1 | Caenorhabditis elegans | Double mutant | 2 | 26.33% .. 31.75% | ||
| Shc1;Terc | Mus musculus | Double mutant | 3 | -38.54% .. -12.44% | ||
| sir-2.1;unc-13 | Caenorhabditis elegans | Double mutant | 2 | 53.41% .. 71.02% | ||
| sir-2.1;unc-51 | Caenorhabditis elegans | Double mutant | 2 | -25.17% .. -102.12% | [est.] | |
| sir-2.1;unc-64 | Caenorhabditis elegans | Double mutant | 1 | 147.53% | ||
| sir-2.1;utx-1 | Caenorhabditis elegans | Double mutant | 2 | 46.17% .. 52.97% | ||
| Sirt6;Trp53 | Mus musculus | Double mutant | 2 | -76.32% .. -67.61% | ||
| skn-1;trpa-1 | Caenorhabditis elegans | Double mutant | 1 | -11.11% | ||
| skn-1;vang-1 | Caenorhabditis elegans | Double mutant | 1 | 27.45% | ||
| snz;snz | Drosophila melanogaster | Double mutant | 2 | 86.54% .. 133.33% | ||
| sod-1;sod-2 | Caenorhabditis elegans | Double mutant | 1 | 65.54% | ||
| sod-1;sod-2;sod-3;sod-4;sod-5 | Caenorhabditis elegans | 5-mutant | 1 | 15.41% | ||
| sod-1;sod-2;sod-4 | Caenorhabditis elegans | Triple mutant | 1 | 31.64% | ||
| sod-1;sod-3 | Caenorhabditis elegans | Double mutant | 1 | 18.64% | ||
| sod-1;sod-3;sod-5 | Caenorhabditis elegans | Triple mutant | 1 | 6.78% | ||
| sod-1;sod-4 | Caenorhabditis elegans | Double mutant | 1 | -1.13% | ||
| sod-1;sod-5 | Caenorhabditis elegans | Double mutant | 1 | 2.82% | ||
| sod-1;xbp-1 | Caenorhabditis elegans | Double mutant | 2 | 11.68% .. 27.52% | ||
| sod-2;sod-3 | Caenorhabditis elegans | Double mutant | 1 | 41.81% | ||
| sod-2;sod-3;sod-5 | Caenorhabditis elegans | Triple mutant | 1 | 14.69% | ||
| sod-2;sod-4 | Caenorhabditis elegans | Double mutant | 1 | 51.41% | ||
| sod-2;sod-5 | Caenorhabditis elegans | Double mutant | 1 | 38.98% | ||
| sod-3;sod-5 | Caenorhabditis elegans | Double mutant | 1 | 12.99% | ||
| Sod1;Sod1 | Drosophila melanogaster | Double mutant | 6 | -98.0% .. -250.0% | [est.] | |
| sun;y | Drosophila melanogaster | Double mutant | 2 | 24.00% .. 60.00% | ||
| taf-4;tpk-1 | Caenorhabditis elegans | Double mutant | 1 | -38.05% .. 151.29% | [est.] | |
| tcer-1;tcer-1 | Caenorhabditis elegans | Double mutant | 4 | 15.59% .. 32.97% | ||
| Terc;Trp53 | Mus musculus | Double mutant | 1 | -86.06% .. -60.22% | [est.] | |
| trpa-1;unc-43 | Caenorhabditis elegans | Double mutant | 1 | 14.05% | ||
| Trx-2;TrxT | Drosophila melanogaster | Double mutant | 1 | -7.68% | ||
| ubc-18;wwp-1 | Caenorhabditis elegans | Double mutant | 2 | -3.76% .. 2.14% | ||
| unc-31;unc-64 | Caenorhabditis elegans | Double mutant | 1 | 79.17% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group