| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| cye-1;glp-1 | Caenorhabditis elegans | Double mutant | 4 | 22.22% .. 33.85% | ||
| cye-1;kri-1 | Caenorhabditis elegans | Double mutant | 3 | 3.19% .. 11.94% | ||
| cye-1;mes-1 | Caenorhabditis elegans | Double mutant | 5 | 13.99% .. 25.91% | ||
| cye-1;rrf-1 | Caenorhabditis elegans | Double mutant | 3 | 15.71% .. 24.74% | ||
| cye-1;skn-1 | Caenorhabditis elegans | Double mutant | 3 | -22.89% .. -14.89% | ||
| cyp-35A2;fat-5 | Caenorhabditis elegans | Double mutant | 1 | 38.26% | ||
| cyp-42A1;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -57.82% | ||
| cyp-42A1;daf-2 | Caenorhabditis elegans | Double mutant | 1 | -41.50% | ||
| Cyp27b1;Fgf23 | Mus musculus | Double mutant | 1 | 0.00% | ||
| D1069.3;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -31.29% | ||
| D1069.3;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 93.20% | ||
| D2013.7;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -33.50% | ||
| D2013.7;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 119.21% | ||
| D2013.7;eat-2 | Caenorhabditis elegans | Double mutant | 1 | 59.11% | ||
| D2030.4;daf-16 | Caenorhabditis elegans | Double mutant | 1 | 11.98% | ||
| D2085.3;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -34.48% | ||
| D2085.3;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 142.36% | ||
| D2085.3;eat-2 | Caenorhabditis elegans | Double mutant | 1 | 38.42% | ||
| D2085.5;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -29.93% | ||
| D2085.5;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 86.39% | ||
| daf-10;daf-16 | Caenorhabditis elegans | Double mutant | 1 | -7.45% | ||
| daf-10;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 97.87% | ||
| daf-10;nmur-1 | Caenorhabditis elegans | Double mutant | 2 | 80.17% .. 86.73% | ||
| daf-12;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -64.62% .. 43.53% | [est.] | |
| daf-12;daf-2 | Caenorhabditis elegans | Double mutant | 2 | -37.06% .. -150.35% | [est.] | |
| daf-12;daf-28 | Caenorhabditis elegans | Double mutant | 1 | -3.38% | ||
| daf-12;daf-2;rsks-1 | Caenorhabditis elegans | Triple mutant | 2 | 7.31% .. 29.65% | [est.] | |
| daf-12;daf-9 | Caenorhabditis elegans | Double mutant | 1 | 4.82% | ||
| daf-12;ddl-1 | Caenorhabditis elegans | Double mutant | 2 | -49.83% .. -202.12% | [est.] | |
| daf-12;ddl-2 | Caenorhabditis elegans | Double mutant | 2 | -55.63% .. -225.65% | [est.] | |
| daf-12;ddl-3 | Caenorhabditis elegans | Double mutant | 2 | -54.47% .. -220.94% | [est.] | |
| daf-12;glp-1 | Caenorhabditis elegans | Double mutant | 3 | -57.95% .. -235.06% | [est.] | |
| daf-12;glp-1;nhr-80 | Caenorhabditis elegans | Triple mutant | 3 | -50.7% .. -205.65% | [est.] | |
| daf-12;gpi-1 | Caenorhabditis elegans | Double mutant | 2 | -45.77% .. -185.65% | [est.] | |
| daf-12;maoc-1 | Caenorhabditis elegans | Double mutant | 2 | -51.57% .. -209.18% | [est.] | |
| daf-12;pkc-2 | Caenorhabditis elegans | Double mutant | 1 | -31.55% .. 177.65% | [est.] | |
| daf-12;sinh-1 | Caenorhabditis elegans | Double mutant | 2 | -49.54% .. -200.94% | [est.] | |
| daf-12;trpa-1 | Caenorhabditis elegans | Double mutant | 1 | -31.55% .. 177.65% | [est.] | |
| daf-12;ttr-1 | Caenorhabditis elegans | Double mutant | 2 | -54.76% .. -222.12% | [est.] | |
| daf-15;daf-16 | Caenorhabditis elegans | Double mutant | 3 | -22.01% .. -13.25% | ||
| daf-15;daf-16;dpy-20;dpy-20 | Caenorhabditis elegans | 4-mutant | 1 | -20.63% | ||
| daf-15;daf-2;dpy-20;dpy-20 | Caenorhabditis elegans | 4-mutant | 1 | 149.21% | ||
| daf-15;ddr-2;let-363 | Caenorhabditis elegans | Triple mutant | 2 | 1.35% .. 3.76% | ||
| daf-15;dpy-20 | Caenorhabditis elegans | Double mutant | 1 | 30.16% | ||
| daf-15;hif-1;unc-24 | Caenorhabditis elegans | Triple mutant | 1 | 22.06% | ||
| daf-15;hsf-1 | Caenorhabditis elegans | Double mutant | 2 | -30.48% .. -27.42% | ||
| daf-15;let-363 | Caenorhabditis elegans | Double mutant | 2 | 30.87% .. 62.61% | ||
| daf-15;skn-1 | Caenorhabditis elegans | Double mutant | 3 | -20.41% .. -17.83% | ||
| daf-15;unc-24 | Caenorhabditis elegans | Double mutant | 5 | 9.55% .. 22.06% | ||
| daf-16;daf-16 | Caenorhabditis elegans | Double mutant | 1 | -37.44% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group