| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| daf-2;pas-6 | Caenorhabditis elegans | Double mutant | 1 | -34.78% | ||
| daf-2;pas-7 | Caenorhabditis elegans | Double mutant | 1 | 64.25% | ||
| daf-2;pat-4 | Caenorhabditis elegans | Double mutant | 1 | 39.5% .. 465.88% | [est.] | |
| daf-2;pat-6 | Caenorhabditis elegans | Double mutant | 1 | 45.88% .. 491.76% | [est.] | |
| daf-2;pbs-2 | Caenorhabditis elegans | Double mutant | 1 | -37.20% | ||
| daf-2;pbs-3 | Caenorhabditis elegans | Double mutant | 1 | -42.51% | ||
| daf-2;pbs-4 | Caenorhabditis elegans | Double mutant | 1 | -41.06% | ||
| daf-2;pbs-5 | Caenorhabditis elegans | Double mutant | 1 | -39.61% | ||
| daf-2;pbs-6 | Caenorhabditis elegans | Double mutant | 1 | -18.36% | ||
| daf-2;pbs-7 | Caenorhabditis elegans | Double mutant | 1 | -40.10% | ||
| daf-2;pek-1 | Caenorhabditis elegans | Double mutant | 7 | 38.24% .. 176.37% | ||
| daf-2;pep-2 | Caenorhabditis elegans | Double mutant | 2 | 134.56% .. 248.18% | ||
| daf-2;pgl-1 | Caenorhabditis elegans | Double mutant | 3 | 56.92% .. 120.46% | ||
| daf-2;pgl-2 | Caenorhabditis elegans | Double mutant | 3 | 53.60% .. 126.84% | ||
| daf-2;pgl-3 | Caenorhabditis elegans | Double mutant | 3 | 58.08% .. 140.43% | ||
| daf-2;pgp-7 | Caenorhabditis elegans | Double mutant | 1 | -24.88% .. 204.71% | [est.] | |
| daf-2;pha-4 | Caenorhabditis elegans | Double mutant | 3 | 43.26% .. 119.59% | ||
| daf-2;pie-1 | Caenorhabditis elegans | Double mutant | 3 | 50.12% .. 112.68% | ||
| daf-2;pmk-1 | Caenorhabditis elegans | Double mutant | 1 | 28.22% | ||
| daf-2;pmq-1 | Caenorhabditis elegans | Double mutant | 2 | 39.76% .. 125.40% | ||
| daf-2;pnk-1 | Caenorhabditis elegans | Double mutant | 1 | 54.42% | ||
| daf-2;pptr-1 | Caenorhabditis elegans | Double mutant | 2 | 25.21% .. 28.69% | ||
| daf-2;pqm-1 | Caenorhabditis elegans | Double mutant | 2 | 44.91% .. 44.91% | ||
| daf-2;prmt-1 | Caenorhabditis elegans | Double mutant | 4 | 141.06% .. 142.24% | ||
| daf-2;prmt-1;prmt-1 | Caenorhabditis elegans | Triple mutant | 4 | -38.52% .. -156.24% | [est.] | |
| daf-2;ptr-23 | Caenorhabditis elegans | Double mutant | 1 | 61.90% | ||
| daf-2;R11A5.4 | Caenorhabditis elegans | Double mutant | 2 | 42.69% .. 173.18% | [est.] | |
| daf-2;R12B2.6 | Caenorhabditis elegans | Double mutant | 1 | 99.32% | ||
| daf-2;R53.4 | Caenorhabditis elegans | Double mutant | 1 | 162.56% | ||
| daf-2;rab-10 | Caenorhabditis elegans | Double mutant | 1 | 13.98% .. 362.35% | [est.] | |
| daf-2;rab-7 | Caenorhabditis elegans | Double mutant | 1 | 34.01% | ||
| daf-2;raga-1 | Caenorhabditis elegans | Double mutant | 5 | -25.75% .. -104.47% | [est.] | |
| daf-2;rff-3 | Caenorhabditis elegans | Double mutant | 6 | -23.72% .. -96.24% | [est.] | |
| daf-2;rha-2 | Caenorhabditis elegans | Double mutant | 1 | 46.75% .. 495.29% | [est.] | |
| daf-2;ril-1 | Caenorhabditis elegans | Double mutant | 1 | 58.64% .. 543.53% | [est.] | |
| daf-2;ril-2 | Caenorhabditis elegans | Double mutant | 1 | 68.21% .. 582.35% | [est.] | |
| daf-2;rpn-1 | Caenorhabditis elegans | Double mutant | 1 | -27.54% | ||
| daf-2;rpn-10 | Caenorhabditis elegans | Double mutant | 1 | 57.49% | ||
| daf-2;rpn-11 | Caenorhabditis elegans | Double mutant | 1 | -24.64% | ||
| daf-2;rpn-12 | Caenorhabditis elegans | Double mutant | 1 | 77.29% | ||
| daf-2;rpn-2 | Caenorhabditis elegans | Double mutant | 1 | -26.09% | ||
| daf-2;rpn-3 | Caenorhabditis elegans | Double mutant | 1 | -21.26% | ||
| daf-2;rpn-5 | Caenorhabditis elegans | Double mutant | 1 | 70.53% | ||
| daf-2;rpn-6 | Caenorhabditis elegans | Double mutant | 1 | -35.27% | ||
| daf-2;rpn-7 | Caenorhabditis elegans | Double mutant | 1 | -31.40% | ||
| daf-2;rpn-8 | Caenorhabditis elegans | Double mutant | 1 | -23.67% | ||
| daf-2;rpn-9 | Caenorhabditis elegans | Double mutant | 1 | 55.56% | ||
| daf-2;rps-15 | Caenorhabditis elegans | Double mutant | 3 | -8.35% .. -33.88% | [est.] | |
| daf-2;rps-22 | Caenorhabditis elegans | Double mutant | 3 | -5.74% .. -23.29% | [est.] | |
| daf-2;rpt-1 | Caenorhabditis elegans | Double mutant | 1 | -27.54% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group