| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| daf-2;lin-14 | Caenorhabditis elegans | Double mutant | 2 | 43.98% .. 158.43% | ||
| daf-2;lin-23 | Caenorhabditis elegans | Double mutant | 29 | -17.18% .. 17.39% | ||
| daf-2;lin-4 | Caenorhabditis elegans | Double mutant | 1 | -13.75% | ||
| daf-2;lipl-4 | Caenorhabditis elegans | Double mutant | 1 | 54.82% | ||
| daf-2;lmn-1 | Caenorhabditis elegans | Double mutant | 1 | 56.46% | ||
| daf-2;lsm-4 | Caenorhabditis elegans | Double mutant | 1 | 95.92% | ||
| daf-2;lsm-7 | Caenorhabditis elegans | Double mutant | 1 | 88.44% | ||
| daf-2;M03F4.7 | Caenorhabditis elegans | Double mutant | 1 | 104.08% | ||
| daf-2;M05B5.2 | Caenorhabditis elegans | Double mutant | 1 | 38.78% | ||
| daf-2;M57.2 | Caenorhabditis elegans | Double mutant | 1 | 55.78% | ||
| daf-2;mag-1 | Caenorhabditis elegans | Double mutant | 1 | 68.71% | ||
| daf-2;maoc-1 | Caenorhabditis elegans | Double mutant | 1 | -15.31% .. 243.53% | [est.] | |
| daf-2;mcm-2 | Caenorhabditis elegans | Double mutant | 1 | 72.11% | ||
| daf-2;mdh-1 | Caenorhabditis elegans | Double mutant | 1 | 118.37% | ||
| daf-2;mdt-15 | Caenorhabditis elegans | Double mutant | 1 | 47.78% | ||
| daf-2;med-1 | Caenorhabditis elegans | Double mutant | 3 | 52.05% .. 163.16% | ||
| daf-2;mekk-3 | Caenorhabditis elegans | Double mutant | 6 | 108.59% .. 267.93% | ||
| daf-2;mep-1 | Caenorhabditis elegans | Double mutant | 1 | 57.82% | ||
| daf-2;mes-4 | Caenorhabditis elegans | Double mutant | 3 | 59.49% .. 119.47% | ||
| daf-2;mml-1 | Caenorhabditis elegans | Double mutant | 1 | 83.78% | ||
| daf-2;mpk-1 | Caenorhabditis elegans | Double mutant | 1 | 17.92% .. 378.35% | [est.] | |
| daf-2;mxl-1 | Caenorhabditis elegans | Double mutant | 1 | 225.00% | ||
| daf-2;mxl-2 | Caenorhabditis elegans | Double mutant | 3 | 40.00% .. 86.49% | ||
| daf-2;nhl-1 | Caenorhabditis elegans | Double mutant | 1 | 105.76% | ||
| daf-2;nhr-49 | Caenorhabditis elegans | Double mutant | 8 | -5.78% .. 150.89% | ||
| daf-2;nhr-62 | Caenorhabditis elegans | Double mutant | 2 | 136.69% .. 218.44% | ||
| daf-2;nhr-8 | Caenorhabditis elegans | Double mutant | 1 | 27.65% | ||
| daf-2;nhr-80 | Caenorhabditis elegans | Double mutant | 2 | 13.11% .. 53.18% | [est.] | |
| daf-2;nit-1 | Caenorhabditis elegans | Double mutant | 1 | -37.35% .. 154.12% | [est.] | |
| daf-2;nmur-1 | Caenorhabditis elegans | Double mutant | 2 | 106.78% .. 216.38% | ||
| daf-2;npa-1 | Caenorhabditis elegans | Double mutant | 1 | 35.73% .. 450.59% | [est.] | |
| daf-2;npp-2 | Caenorhabditis elegans | Double mutant | 1 | 58.50% | ||
| daf-2;npp-3 | Caenorhabditis elegans | Double mutant | 1 | 65.99% | ||
| daf-2;npr-1 | Caenorhabditis elegans | Double mutant | 3 | 88.99% .. 150.63% | ||
| daf-2;nsh-1 | Caenorhabditis elegans | Double mutant | 1 | 58.50% | ||
| daf-2;nspb-7 | Caenorhabditis elegans | Double mutant | 1 | -14.44% .. 247.06% | [est.] | |
| daf-2;ntl-3 | Caenorhabditis elegans | Double mutant | 1 | 43.54% | ||
| daf-2;nuo-2 | Caenorhabditis elegans | Double mutant | 1 | 40.66% .. 470.59% | [est.] | |
| daf-2;nuo-3 | Caenorhabditis elegans | Double mutant | 1 | 89.1% .. 667.06% | [est.] | |
| daf-2;nuo-4 | Caenorhabditis elegans | Double mutant | 1 | 103.31% .. 724.71% | [est.] | |
| daf-2;nuo-5 | Caenorhabditis elegans | Double mutant | 1 | 68.79% .. 584.71% | [est.] | |
| daf-2;nuo-6 | Caenorhabditis elegans | Double mutant | 2 | 155.68% .. 164.32% | ||
| daf-2;odr-3 | Caenorhabditis elegans | Double mutant | 1 | 175.56% | ||
| daf-2;oga-1 | Caenorhabditis elegans | Double mutant | 1 | 35.85% | ||
| daf-2;ogt-1 | Caenorhabditis elegans | Double mutant | 1 | -16.98% | ||
| daf-2;osm-3 | Caenorhabditis elegans | Double mutant | 1 | 112.77% | ||
| daf-2;par-4 | Caenorhabditis elegans | Double mutant | 1 | 27.32% | ||
| daf-2;par-5 | Caenorhabditis elegans | Double mutant | 3 | 90.00% .. 232.43% | ||
| daf-2;pas-1 | Caenorhabditis elegans | Double mutant | 1 | 63.29% | ||
| daf-2;pas-5 | Caenorhabditis elegans | Double mutant | 1 | -24.15% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group