| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| daf-2;rpt-2 | Caenorhabditis elegans | Double mutant | 1 | 60.39% | ||
| daf-2;rpt-3 | Caenorhabditis elegans | Double mutant | 1 | -22.71% | ||
| daf-2;rpt-4 | Caenorhabditis elegans | Double mutant | 1 | -24.64% | ||
| daf-2;rpt-5 | Caenorhabditis elegans | Double mutant | 1 | -27.05% | ||
| daf-2;rpt-6 | Caenorhabditis elegans | Double mutant | 1 | -23.67% | ||
| daf-2;rrf-3 | Caenorhabditis elegans | Double mutant | 11 | 88.94% | ||
| daf-2;rrf-3;skn-1 | Caenorhabditis elegans | Triple mutant | 1 | 26.37% | ||
| daf-2;rrf-3;sod-3 | Caenorhabditis elegans | Triple mutant | 1 | -4.87% .. 285.88% | [est.] | |
| daf-2;rrf-3;T20G5.8 | Caenorhabditis elegans | Triple mutant | 1 | 11.37% .. 351.76% | [est.] | |
| daf-2;rsks-1 | Caenorhabditis elegans | Double mutant | 32 | 103.13% .. 454.40% | ||
| daf-2;rsks-1;tax-6 | Caenorhabditis elegans | Triple mutant | 2 | 141.21% .. 188.70% | ||
| daf-2;rsks-1;ubl-5 | Caenorhabditis elegans | Triple mutant | 3 | 64.97% .. 82.83% | ||
| daf-2;sams-1 | Caenorhabditis elegans | Double mutant | 1 | 71.69% .. 596.47% | [est.] | |
| daf-2;sca-1 | Caenorhabditis elegans | Double mutant | 1 | 96.06% | ||
| daf-2;scl-1 | Caenorhabditis elegans | Double mutant | 1 | 34.75% | ||
| daf-2;sdc-2 | Caenorhabditis elegans | Double mutant | 1 | 119.73% | ||
| daf-2;sea-2 | Caenorhabditis elegans | Double mutant | 1 | 112.14% | ||
| daf-2;sem-5 | Caenorhabditis elegans | Double mutant | 2 | 46.02% .. 55.68% | ||
| daf-2;sgk-1 | Caenorhabditis elegans | Double mutant | 1 | 144.90% | ||
| daf-2;shc-1 | Caenorhabditis elegans | Double mutant | 1 | 41.26% | ||
| daf-2;sinh-1 | Caenorhabditis elegans | Double mutant | 1 | -24.01% .. 208.24% | [est.] | |
| daf-2;sir-2.1 | Caenorhabditis elegans | Double mutant | 2 | 171.35% | ||
| daf-2;skn-1 | Caenorhabditis elegans | Double mutant | 30 | -38.01% .. 88.85% | ||
| daf-2;skr-1 | Caenorhabditis elegans | Double mutant | 7 | -36.19% .. -146.82% | [est.] | |
| daf-2;skr-11 | Caenorhabditis elegans | Double mutant | 2 | -26.62% .. -108.0% | [est.] | |
| daf-2;skr-12 | Caenorhabditis elegans | Double mutant | 2 | -20.53% .. -83.29% | [est.] | |
| daf-2;skr-13 | Caenorhabditis elegans | Double mutant | 2 | -24.3% .. -98.59% | [est.] | |
| daf-2;skr-15 | Caenorhabditis elegans | Double mutant | 1 | -13.86% .. 249.41% | [est.] | |
| daf-2;skr-19 | Caenorhabditis elegans | Double mutant | 2 | -21.4% .. -86.82% | [est.] | |
| daf-2;skr-2 | Caenorhabditis elegans | Double mutant | 7 | -53.6% .. -217.41% | [est.] | |
| daf-2;skr-20 | Caenorhabditis elegans | Double mutant | 2 | -23.72% .. -96.24% | [est.] | |
| daf-2;skr-3 | Caenorhabditis elegans | Double mutant | 2 | -18.21% .. -73.88% | [est.] | |
| daf-2;skr-5 | Caenorhabditis elegans | Double mutant | 1 | -16.47% .. 238.82% | [est.] | |
| daf-2;skr-7 | Caenorhabditis elegans | Double mutant | 2 | -23.72% .. -96.24% | [est.] | |
| daf-2;skr-8 | Caenorhabditis elegans | Double mutant | 2 | -19.66% .. -79.76% | [est.] | |
| daf-2;smk-1 | Caenorhabditis elegans | Double mutant | 2 | 44.90% .. 45.36% | ||
| daf-2;smn-1 | Caenorhabditis elegans | Double mutant | 1 | 54.42% | ||
| daf-2;sod-1;sod-2;sod-3;sod-4;sod-5 | Caenorhabditis elegans | 6-mutant | 1 | 154.02% | ||
| daf-2;sod-2 | Caenorhabditis elegans | Double mutant | 2 | 80.62% .. 258.76% | ||
| daf-2;sod-2;sod-3 | Caenorhabditis elegans | Triple mutant | 1 | 148.02% | ||
| daf-2;sod-3 | Caenorhabditis elegans | Double mutant | 1 | 152.42% | ||
| daf-2;sod-4 | Caenorhabditis elegans | Double mutant | 1 | 180.62% | ||
| daf-2;sos-1 | Caenorhabditis elegans | Double mutant | 2 | 68.18% .. 69.32% | ||
| daf-2;spl-1 | Caenorhabditis elegans | Double mutant | 1 | -5.44% | ||
| daf-2;T14G10.1 | Caenorhabditis elegans | Double mutant | 1 | 79.59% | ||
| daf-2;T19B10.2 | Caenorhabditis elegans | Double mutant | 1 | -27.89% | ||
| daf-2;T22B11.2 | Caenorhabditis elegans | Double mutant | 1 | 95.92% | ||
| daf-2;T27F7.1 | Caenorhabditis elegans | Double mutant | 1 | 44.22% | ||
| daf-2;tag-249 | Caenorhabditis elegans | Double mutant | 1 | -51.02% | ||
| daf-2;tag-318 | Caenorhabditis elegans | Double mutant | 1 | 88.44% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group