| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| daf-16;pat-4 | Caenorhabditis elegans | Double mutant | 1 | -55.05% .. 82.35% | [est.] | |
| daf-16;pat-4;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | 5.92% | ||
| daf-16;pat-6 | Caenorhabditis elegans | Double mutant | 1 | -57.66% .. 71.76% | [est.] | |
| daf-16;pdk-1 | Caenorhabditis elegans | Double mutant | 2 | -20.11% .. -11.76% | ||
| daf-16;pep-2 | Caenorhabditis elegans | Double mutant | 2 | -32.73% .. -31.62% | ||
| daf-16;pkc-2 | Caenorhabditis elegans | Double mutant | 4 | -26.26% .. -13.57% | ||
| daf-16;pmq-1 | Caenorhabditis elegans | Double mutant | 1 | -22.18% | ||
| daf-16;pod-1;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -40.81% | ||
| daf-16;prmt-1 | Caenorhabditis elegans | Double mutant | 6 | -68.1% .. -276.24% | [est.] | |
| daf-16;qars-1;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -0.43% | ||
| daf-16;R05A10.5;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -69.34% .. 24.35% | [est.] | |
| daf-16;R08E3.3;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -72.22% .. 12.71% | [est.] | |
| daf-16;R10H10.7;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -19.86% | ||
| daf-16;rab-10 | Caenorhabditis elegans | Double mutant | 1 | -58.24% .. 69.41% | [est.] | |
| daf-16;raga-1 | Caenorhabditis elegans | Double mutant | 6 | -32.32% .. -14.43% | ||
| daf-16;raga-1;skn-1 | Caenorhabditis elegans | Triple mutant | 3 | -19.87% .. -14.98% | ||
| daf-16;ragc-1 | Caenorhabditis elegans | Double mutant | 4 | -16.89% .. -5.61% | ||
| daf-16;ral-1;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -14.44% | ||
| daf-16;rha-2 | Caenorhabditis elegans | Double mutant | 1 | -53.02% .. 90.59% | [est.] | |
| daf-16;rheb-1 | Caenorhabditis elegans | Double mutant | 4 | -12.74% .. -11.24% | ||
| daf-16;rict-1 | Caenorhabditis elegans | Double mutant | 2 | -49.29% .. -49.14% | ||
| daf-16;ril-1 | Caenorhabditis elegans | Double mutant | 1 | -50.99% .. 98.82% | [est.] | |
| daf-16;ril-2 | Caenorhabditis elegans | Double mutant | 1 | -53.6% .. 88.24% | [est.] | |
| daf-16;rle-1 | Caenorhabditis elegans | Double mutant | 3 | -17.80% .. 32.98% | ||
| daf-16;rpl-19 | Caenorhabditis elegans | Double mutant | 1 | -59.11% .. 65.88% | [est.] | |
| daf-16;rpl-4 | Caenorhabditis elegans | Double mutant | 1 | -58.24% .. 69.41% | [est.] | |
| daf-16;rps-15 | Caenorhabditis elegans | Double mutant | 5 | -59.4% .. -240.94% | [est.] | |
| daf-16;rps-22 | Caenorhabditis elegans | Double mutant | 3 | -58.82% .. -238.59% | [est.] | |
| daf-16;rps-23;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | 46.21% | ||
| daf-16;rrf-3 | Caenorhabditis elegans | Double mutant | 13 | -12.62% | ||
| daf-16;rrf-3;scl-8 | Caenorhabditis elegans | Triple mutant | 1 | 4.35% | ||
| daf-16;rrf-3;set-26 | Caenorhabditis elegans | Triple mutant | 1 | -2.98% | ||
| daf-16;rrf-3;spe-26 | Caenorhabditis elegans | Triple mutant | 1 | -18.33% | ||
| daf-16;rrf-3;T05A1.5 | Caenorhabditis elegans | Triple mutant | 1 | -12.79% | ||
| daf-16;rrf-3;T05G5.10 | Caenorhabditis elegans | Triple mutant | 1 | -70.45% .. 19.88% | [est.] | |
| daf-16;rrf-3;T06G6.4 | Caenorhabditis elegans | Triple mutant | 1 | -77.99% .. -10.71% | [est.] | |
| daf-16;rrf-3;T20H4.5 | Caenorhabditis elegans | Triple mutant | 1 | -71.37% .. 16.12% | [est.] | |
| daf-16;rrf-3;T28A8.6 | Caenorhabditis elegans | Triple mutant | 1 | -6.24% | ||
| daf-16;rrf-3;T28D6.4 | Caenorhabditis elegans | Triple mutant | 1 | -9.79% | ||
| daf-16;rrf-3;tes-1 | Caenorhabditis elegans | Triple mutant | 1 | 5.54% | ||
| daf-16;rrf-3;tkt-1 | Caenorhabditis elegans | Triple mutant | 1 | 6.31% | ||
| daf-16;rrf-3;ttr-5 | Caenorhabditis elegans | Triple mutant | 1 | -23.13% | ||
| daf-16;rrf-3;W03G1.5 | Caenorhabditis elegans | Triple mutant | 1 | 8.78% | ||
| daf-16;rrf-3;W05B2.5 | Caenorhabditis elegans | Triple mutant | 1 | -66.39% .. 36.35% | [est.] | |
| daf-16;rrf-3;Y119D3_446.d | Caenorhabditis elegans | Triple mutant | 1 | -21.31% | ||
| daf-16;rrf-3;Y39F10C.1 | Caenorhabditis elegans | Triple mutant | 1 | -78.77% .. -13.88% | [est.] | |
| daf-16;rrf-3;Y39H10A_224.b | Caenorhabditis elegans | Triple mutant | 1 | -69.78% .. 22.59% | [est.] | |
| daf-16;rrf-3;Y43H11_160.a | Caenorhabditis elegans | Triple mutant | 1 | -66.24% .. 36.94% | [est.] | |
| daf-16;rrf-3;Y45F10D.8 | Caenorhabditis elegans | Triple mutant | 1 | -10.14% | ||
| daf-16;rrf-3;Y46H3C_13.a | Caenorhabditis elegans | Triple mutant | 1 | -70.65% .. 19.06% | [est.] |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group