| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| daf-16;rrf-3;Y50D4A_25.a | Caenorhabditis elegans | Triple mutant | 1 | -70.1% .. 21.29% | [est.] | |
| daf-16;rrf-3;Y54E5A.7 | Caenorhabditis elegans | Triple mutant | 1 | -74.45% .. 3.65% | [est.] | |
| daf-16;rrf-3;Y56A3A.9 | Caenorhabditis elegans | Triple mutant | 1 | -69.63% .. 23.18% | [est.] | |
| daf-16;rrf-3;Y66A7A1 | Caenorhabditis elegans | Triple mutant | 1 | -3.63% | ||
| daf-16;rrf-3;Y69A2A_2991.c | Caenorhabditis elegans | Triple mutant | 1 | 3.50% | ||
| daf-16;rrf-3;Y71H2_380.a | Caenorhabditis elegans | Triple mutant | 1 | -69.75% .. 22.71% | [est.] | |
| daf-16;rrf-3;Y71H2_388.c† | Caenorhabditis elegans | Triple mutant | 1 | 55.80% | ||
| daf-16;rrf-3;Y71H2_390.d | Caenorhabditis elegans | Triple mutant | 1 | -13.18% | ||
| daf-16;rrf-3;Y75B8A.13 | Caenorhabditis elegans | Triple mutant | 1 | -69.81% .. 22.47% | [est.] | |
| daf-16;rrf-3;Y75B8A.33 | Caenorhabditis elegans | Triple mutant | 1 | -71.78% .. 14.47% | [est.] | |
| daf-16;rrf-3;ZC64.3 | Caenorhabditis elegans | Triple mutant | 1 | -73.49% .. 7.53% | [est.] | |
| daf-16;rrf3 | Caenorhabditis elegans | Double mutant | 2 | -23.38% .. -18.39% | ||
| daf-16;rsks-1 | Caenorhabditis elegans | Double mutant | 9 | -31.96% .. -17.09% | ||
| daf-16;sams-1 | Caenorhabditis elegans | Double mutant | 1 | -52.44% .. 92.94% | [est.] | |
| daf-16;sca-1 | Caenorhabditis elegans | Double mutant | 1 | -37.44% | ||
| daf-16;sea-2 | Caenorhabditis elegans | Double mutant | 1 | -30.06% | ||
| daf-16;sgk-1 | Caenorhabditis elegans | Double mutant | 7 | -36.71% .. 7.43% | ||
| daf-16;shc-1 | Caenorhabditis elegans | Double mutant | 2 | -34.42% .. -22.92% | ||
| daf-16;sinh-1 | Caenorhabditis elegans | Double mutant | 2 | -59.69% .. -242.12% | [est.] | |
| daf-16;sir-2.1 | Caenorhabditis elegans | Double mutant | 7 | -43.71% .. -25.00% | ||
| daf-16;sir-2.1;unc-13 | Caenorhabditis elegans | Triple mutant | 2 | 5.68% .. 19.89% | ||
| daf-16;sir-2.1;unc-51 | Caenorhabditis elegans | Triple mutant | 1 | -63.17% .. 49.41% | [est.] | |
| daf-16;skn-1 | Caenorhabditis elegans | Double mutant | 9 | -50.64% .. -7.53% | ||
| daf-16;smk-1 | Caenorhabditis elegans | Double mutant | 1 | -42.08% | ||
| daf-16;sod-1 | Caenorhabditis elegans | Double mutant | 4 | -59.69% .. -242.12% | [est.] | |
| daf-16;sod-2 | Caenorhabditis elegans | Double mutant | 1 | -15.00% | ||
| daf-16;T02H6.11 | Caenorhabditis elegans | Double mutant | 1 | 22.40% | ||
| daf-16;T06D8.6 | Caenorhabditis elegans | Double mutant | 1 | -14.06% | ||
| daf-16;tax-4 | Caenorhabditis elegans | Double mutant | 1 | -7.98% | ||
| daf-16;tax-6 | Caenorhabditis elegans | Double mutant | 2 | -17.31% .. 19.05% | ||
| daf-16;tcer-1 | Caenorhabditis elegans | Double mutant | 5 | -21.33% .. 2.42% | ||
| daf-16;trpa-1 | Caenorhabditis elegans | Double mutant | 6 | -15.51% .. -11.40% | ||
| daf-16;ttr-1 | Caenorhabditis elegans | Double mutant | 2 | -60.56% .. -245.65% | [est.] | |
| daf-16;tub-1 | Caenorhabditis elegans | Double mutant | 1 | -18.57% | ||
| daf-16;unc-13 | Caenorhabditis elegans | Double mutant | 2 | 22.73% .. 35.80% | ||
| daf-16;unc-31 | Caenorhabditis elegans | Double mutant | 3 | -39.20% .. -13.64% | ||
| daf-16;unc-51 | Caenorhabditis elegans | Double mutant | 1 | -62.59% .. 51.76% | [est.] | |
| daf-16;unc-64 | Caenorhabditis elegans | Double mutant | 1 | -9.09% | ||
| daf-16;unc-70 | Caenorhabditis elegans | Double mutant | 1 | -37.93% | ||
| daf-16;utx-1 | Caenorhabditis elegans | Double mutant | 5 | -43.97% .. -8.79% | ||
| daf-16;vang-1 | Caenorhabditis elegans | Double mutant | 2 | 5.14% .. 17.65% | ||
| daf-16;vhl-1 | Caenorhabditis elegans | Double mutant | 3 | -5.56% .. 5.56% | ||
| daf-16;W09C5.8 | Caenorhabditis elegans | Double mutant | 1 | 34.90% | ||
| daf-16;wwp-1 | Caenorhabditis elegans | Double mutant | 2 | 8.76% .. 16.02% | ||
| daf-18;daf-2 | Caenorhabditis elegans | Double mutant | 7 | -15.79% .. 8.33% | ||
| daf-18;daf-23 | Caenorhabditis elegans | Double mutant | 1 | -16.76% .. 237.65% | [est.] | |
| daf-18;rrf-3 | Caenorhabditis elegans | Double mutant | 1 | -71.29% .. 16.47% | [est.] | |
| daf-1;hif-1 | Caenorhabditis elegans | Double mutant | 1 | 161.44% | ||
| daf-22;mekk-3 | Caenorhabditis elegans | Double mutant | 2 | -5.31% .. -1.53% | ||
| daf-28;ins-6 | Caenorhabditis elegans | Double mutant | 1 | 18.46% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group