| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| daf-2;daf-2 | Caenorhabditis elegans | Double mutant | 6 | 93.70% .. 200.26% | ||
| daf-2;daf-20 | Caenorhabditis elegans | Double mutant | 1 | 163.16% | ||
| daf-2;daf-2;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 3 | -59.69% .. -242.12% | [est.] | |
| daf-2;daf-2;mxl-1 | Caenorhabditis elegans | Triple mutant | 1 | 250.00% | ||
| daf-2;daf-2;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | 31.67% .. 434.12% | [est.] | |
| daf-2;daf-2;skn-1 | Caenorhabditis elegans | Triple mutant | 2 | -21.22% .. 13.10% | ||
| daf-2;daf-3 | Caenorhabditis elegans | Double mutant | 7 | 16.40% .. 177.38% | ||
| daf-2;daf-3;mekk-3 | Caenorhabditis elegans | Triple mutant | 2 | 290.52% .. 294.08% | ||
| daf-2;daf-9 | Caenorhabditis elegans | Double mutant | 1 | 41.13% | ||
| daf-2;dao-3;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 2 | -30.1% .. -122.12% | [est.] | |
| daf-2;dct-5 | Caenorhabditis elegans | Double mutant | 1 | -30.97% .. 180.0% | [est.] | |
| daf-2;ddl-1 | Caenorhabditis elegans | Double mutant | 1 | -23.14% .. 211.76% | [est.] | |
| daf-2;ddl-2 | Caenorhabditis elegans | Double mutant | 1 | -18.5% .. 230.59% | [est.] | |
| daf-2;ddl-3 | Caenorhabditis elegans | Double mutant | 1 | -24.3% .. 207.06% | [est.] | |
| daf-2;dev-1 | Caenorhabditis elegans | Double mutant | 1 | 98.20% | ||
| daf-2;dod-10;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 1 | -26.04% .. 200.0% | [est.] | |
| daf-2;dod-11;dod-14;fem-1;fer-15 | Caenorhabditis elegans | 5-mutant | 1 | -25.75% .. 201.18% | [est.] | |
| daf-2;dod-11;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 2 | -34.45% .. -139.76% | [est.] | |
| daf-2;dod-12;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 1 | -24.88% .. 204.71% | [est.] | |
| daf-2;dod-13;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 3 | -40.55% .. -164.47% | [est.] | |
| daf-2;dod-14;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 2 | -24.88% .. -100.94% | [est.] | |
| daf-2;dod-15;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 1 | -20.53% .. 222.35% | [est.] | |
| daf-2;dod-16;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 2 | -12.99% .. -52.71% | [est.] | |
| daf-2;dod-1;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 2 | -55.34% .. -224.47% | [est.] | |
| daf-2;dod-2;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 2 | -46.64% .. -189.18% | [est.] | |
| daf-2;dod-2;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | 3.25% .. 318.82% | [est.] | |
| daf-2;dod-3;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 2 | -42.58% .. -172.71% | [est.] | |
| daf-2;dod-4;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 1 | -35.32% .. 162.35% | [est.] | |
| daf-2;dod-5;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 1 | -46.06% .. 118.82% | [est.] | |
| daf-2;dod-6;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 3 | -35.03% .. -142.12% | [est.] | |
| daf-2;dod-7;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 1 | -28.65% .. 189.41% | [est.] | |
| daf-2;dod-8;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 1 | -26.91% .. 196.47% | [est.] | |
| daf-2;dod-9;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 1 | -26.91% .. 196.47% | [est.] | |
| daf-2;dox-1 | Caenorhabditis elegans | Double mutant | 6 | 18.01% .. 74.59% | ||
| daf-2;dpy-20 | Caenorhabditis elegans | Double mutant | 1 | 121.43% | ||
| daf-2;drp-1 | Caenorhabditis elegans | Double mutant | 2 | 165.59% .. 226.53% | ||
| daf-2;drr-1 | Caenorhabditis elegans | Double mutant | 1 | -10.67% .. 262.35% | [est.] | |
| daf-2;drr-2 | Caenorhabditis elegans | Double mutant | 2 | 19.2% .. 77.88% | [est.] | |
| daf-2;dve-1;rsks-1 | Caenorhabditis elegans | Triple mutant | 3 | -9.31% .. 14.21% | ||
| daf-2;eak-3 | Caenorhabditis elegans | Double mutant | 1 | 300.39% | ||
| daf-2;eat-2 | Caenorhabditis elegans | Double mutant | 2 | 89.95% .. 132.51% | ||
| daf-2;egl-27 | Caenorhabditis elegans | Double mutant | 4 | 58.71% | ||
| daf-2;egr-1 | Caenorhabditis elegans | Double mutant | 3 | 24.84% .. 60.54% | ||
| daf-2;elo-5 | Caenorhabditis elegans | Double mutant | 1 | 84.35% | ||
| daf-2;elt-1 | Caenorhabditis elegans | Double mutant | 3 | 76.03% .. 130.83% | ||
| daf-2;elt-2 | Caenorhabditis elegans | Double mutant | 3 | 2.74% .. 51.13% | ||
| daf-2;elt-3 | Caenorhabditis elegans | Double mutant | 6 | 0.68% .. 91.65% | ||
| daf-2;elt-5 | Caenorhabditis elegans | Double mutant | 3 | -60.90% .. -5.48% | ||
| daf-2;elt-6 | Caenorhabditis elegans | Double mutant | 3 | 47.26% .. 130.83% | ||
| daf-2;end-1 | Caenorhabditis elegans | Double mutant | 2 | 6.16% .. 103.01% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group