| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| C34B4.1;daf-16;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -71.4% .. 16.0% | [est.] | |
| C36H8.1;daf-16;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -69.26% .. 24.71% | [est.] | |
| C36H8.1;rrf-3;sir-2.1 | Caenorhabditis elegans | Triple mutant | 1 | -56.26% .. 77.41% | [est.] | |
| C38C3.5;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -26.53% | ||
| C38C3.5;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 94.56% | ||
| C39E9.1;daf-16;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -70.65% .. 19.06% | [est.] | |
| C39E9.1;rrf-3;sir-2.1 | Caenorhabditis elegans | Triple mutant | 1 | -51.71% .. 95.88% | [est.] | |
| C40H1.8i;eat-2;lin-15b;nre-1 | Caenorhabditis elegans | 4-mutant | 1 | -56.09% .. 78.12% | [est.] | |
| C40H1.8i;lin-15b;nre-1 | Caenorhabditis elegans | Triple mutant | 1 | -60.9% .. 58.59% | [est.] | |
| C40H5.6;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -43.54% | ||
| C40H5.6;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 39.46% | ||
| C42C1.3;daf-16;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -9.80% | ||
| C46G7.2;daf-16;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -23.87% | ||
| C47D12.6;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -36.45% | ||
| C47D12.6;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 98.52% | ||
| C47D12.6;eat-2 | Caenorhabditis elegans | Double mutant | 1 | 24.63% | ||
| C48E7.2;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -33.00% | ||
| C48E7.2;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 114.78% | ||
| C48E7.2;eat-2 | Caenorhabditis elegans | Double mutant | 1 | 48.77% | ||
| C51E3.7;daf-16;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -68.36% .. 28.35% | [est.] | |
| C56E6.1;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -33.00% | ||
| C56E6.1;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 131.03% | ||
| C56E6.1;eat-2 | Caenorhabditis elegans | Double mutant | 1 | 43.35% | ||
| Cat;Sod1 | Drosophila melanogaster | Double mutant | 24 | -37.08% .. 29.03% | ||
| cbp-1;clk-1 | Caenorhabditis elegans | Double mutant | 1 | -20.07% | ||
| cbp-1;daf-16 | Caenorhabditis elegans | Double mutant | 1 | -41.46% | ||
| cbp-1;daf-16;rrf3 | Caenorhabditis elegans | Triple mutant | 1 | -22.86% | ||
| cbp-1;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 21.41% | ||
| cbp-1;eat-2 | Caenorhabditis elegans | Double mutant | 1 | -27.81% | ||
| cbp-1;glp-1 | Caenorhabditis elegans | Double mutant | 1 | -4.98% | ||
| cbp-1;mev-1 | Caenorhabditis elegans | Double mutant | 1 | -25.85% | ||
| cbp-1;rrf3 | Caenorhabditis elegans | Double mutant | 5 | -28.50% .. -16.45% | ||
| cchl-1;daf-16 | Caenorhabditis elegans | Double mutant | 1 | -49.25% .. 105.88% | [est.] | |
| cchl-1;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 13.4% .. 360.0% | [est.] | |
| cchl-1;fem-1;fer-15 | Caenorhabditis elegans | Triple mutant | 1 | -48.09% .. 110.59% | [est.] | |
| cco-1;cep-1 | Caenorhabditis elegans | Double mutant | 1 | 69.81% | ||
| cco-1;daf-16 | Caenorhabditis elegans | Double mutant | 1 | -57.66% .. 71.76% | [est.] | |
| cco-1;daf-16;skn-1 | Caenorhabditis elegans | Triple mutant | 2 | 7.28% .. 23.18% | ||
| cco-1;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 40.08% .. 468.24% | [est.] | |
| cco-1;fem-1;fer-15 | Caenorhabditis elegans | Triple mutant | 1 | -44.9% .. 123.53% | [est.] | |
| cco-1;hif-1 | Caenorhabditis elegans | Double mutant | 1 | 43.88% | ||
| cco-1;kin-29 | Caenorhabditis elegans | Double mutant | 1 | 44.19% | ||
| cco-1;mml-1 | Caenorhabditis elegans | Double mutant | 1 | 51.16% | ||
| cco-1;nhr-49 | Caenorhabditis elegans | Double mutant | 2 | -16.57% .. 14.12% | ||
| cco-1;nhr-62 | Caenorhabditis elegans | Double mutant | 2 | 92.42% .. 109.40% | ||
| cco-1;par-4 | Caenorhabditis elegans | Double mutant | 1 | 64.53% | ||
| cco-1;sad-1 | Caenorhabditis elegans | Double mutant | 1 | 22.09% | ||
| cco-2;daf-16 | Caenorhabditis elegans | Double mutant | 1 | -28.07% .. 191.76% | [est.] | |
| cco-2;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 54.0% .. 524.71% | [est.] | |
| cco-2;fem-1;fer-15 | Caenorhabditis elegans | Triple mutant | 1 | -20.82% .. 221.18% | [est.] |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group