| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| ccr-4;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -42.86% | ||
| ccr-4;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 62.59% | ||
| CD4.4;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -48.98% | ||
| CD4.4;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 38.78% | ||
| cdk-2;daf-16 | Caenorhabditis elegans | Double mutant | 3 | -5.46% .. 3.63% | ||
| cdk-2;glp-1 | Caenorhabditis elegans | Double mutant | 3 | 19.69% .. 25.40% | ||
| cdk-2;kri-1 | Caenorhabditis elegans | Double mutant | 3 | 1.06% .. 12.44% | ||
| cdk-2;skn-1 | Caenorhabditis elegans | Double mutant | 3 | -14.87% .. -13.24% | ||
| Cdkn1a;Terc | Mus musculus | Double mutant | 1 | -43.13% .. 62.37% | [est.] | |
| cdr-5;rrf-3 | Caenorhabditis elegans | Double mutant | 1 | -26.33% .. 198.82% | [est.] | |
| Ce-atg7;eat-2 | Caenorhabditis elegans | Double mutant | 1 | -8.14% | ||
| ced-13;ced-4;isp-1 | Caenorhabditis elegans | Triple mutant | 3 | 25.27% .. 30.36% | ||
| ced-13;ced-4;nuo-6 | Caenorhabditis elegans | Triple mutant | 3 | 24.38% .. 34.01% | ||
| ced-13;isp-1 | Caenorhabditis elegans | Double mutant | 3 | 12.64% .. 36.05% | ||
| ced-13;nuo-6 | Caenorhabditis elegans | Double mutant | 3 | 32.25% .. 41.85% | ||
| ced-3;unc-51 | Caenorhabditis elegans | Double mutant | 1 | -26.91% .. 196.47% | [est.] | |
| ced-4;cyc-2.1 | Caenorhabditis elegans | Double mutant | 1 | -9.77% .. 266.0% | [est.] | |
| ced-4;egl-1;isp-1 | Caenorhabditis elegans | Triple mutant | 3 | 30.71% .. 34.28% | ||
| ced-4;egl-1;nuo-6 | Caenorhabditis elegans | Triple mutant | 3 | 31.90% .. 40.04% | ||
| ced-4;isp-1 | Caenorhabditis elegans | Double mutant | 5 | 25.46% .. 43.92% | ||
| ced-4;nuo-6 | Caenorhabditis elegans | Double mutant | 9 | 25.24% .. 60.88% | ||
| ceh-18;isp-1 | Caenorhabditis elegans | Double mutant | 1 | -36.75% .. 156.59% | [est.] | |
| ceh-18;tpk-1 | Caenorhabditis elegans | Double mutant | 1 | -12.91% .. 253.29% | [est.] | |
| ceh-23;ctb-1;isp-1 | Caenorhabditis elegans | Triple mutant | 18 | 9.36% .. 52.07% | ||
| ceh-23;isp-1 | Caenorhabditis elegans | Double mutant | 14 | -4.59% .. 42.90% | ||
| ceh-24;isp-1 | Caenorhabditis elegans | Double mutant | 1 | -20.33% .. 223.18% | [est.] | |
| cel-1;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -43.54% | ||
| cel-1;daf-2 | Caenorhabditis elegans | Double mutant | 1 | -39.46% | ||
| cep-1;clk-1 | Caenorhabditis elegans | Double mutant | 5 | -15.06% .. 18.18% | ||
| cep-1;cyc-2.1 | Caenorhabditis elegans | Double mutant | 1 | 2.81% .. 317.06% | [est.] | |
| cep-1;frh-1 | Caenorhabditis elegans | Double mutant | 1 | 33.33% | ||
| cep-1;ftn-1;ftn-2 | Caenorhabditis elegans | Triple mutant | 2 | 1.46% .. 10.32% | ||
| cep-1;ftn-1;ftn-2;isp-1 | Caenorhabditis elegans | 4-mutant | 2 | 8.06% .. 35.04% | ||
| cep-1;ftn-1;ftn-2;mev-1 | Caenorhabditis elegans | 4-mutant | 2 | -16.22% .. -11.60% | ||
| cep-1;gas-1 | Caenorhabditis elegans | Double mutant | 5 | -19.88% .. 22.21% | ||
| cep-1;isp-1 | Caenorhabditis elegans | Double mutant | 6 | 9.62% .. 82.39% | ||
| cep-1;mev-1 | Caenorhabditis elegans | Double mutant | 12 | -16.28% .. 16.65% | ||
| cep-1;nuo-6 | Caenorhabditis elegans | Double mutant | 1 | 3.35% | ||
| chc-1;daf-16 | Caenorhabditis elegans | Double mutant | 1 | -37.93% | ||
| chc-1;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 86.70% | ||
| chc-1;eat-2 | Caenorhabditis elegans | Double mutant | 1 | 18.72% | ||
| chc-1;ifg-1 | Caenorhabditis elegans | Double mutant | 2 | 4.87% .. 8.87% | ||
| chc-1;isp-1 | Caenorhabditis elegans | Double mutant | 1 | 45.81% | ||
| chc-1;rsks-1 | Caenorhabditis elegans | Double mutant | 1 | 13.30% | ||
| chico;foxo | Drosophila melanogaster | Double mutant | 2 | -12.50% .. | ||
| chico;ovo | Drosophila melanogaster | Double mutant | 1 | 34.09% | ||
| cit-1.2;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -33.33% | ||
| cit-1.2;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 88.44% | ||
| cku-70;daf-16 | Caenorhabditis elegans | Double mutant | 1 | -9.22% | ||
| cku-70;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | 2.84% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group