| All mutants (36 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| Apc;Egr1 | Double mutant | 2 | -83.24% .. -237.63% | [est.] | |
| Apc;Egr1;Trp53 | Triple mutant | 1 | -83.24% .. -52.15% | [est.] | |
| Apc;Ku80 | Double mutant | 2 | -73.60% .. -66.40% | ||
| Apc;Trp53 | Double mutant | 1 | -86.44% .. -61.29% | [est.] | |
| Atm;Rad54 | Double mutant | 1 | -86.82% .. -62.37% | [est.] | |
| Atm;Rad54B | Double mutant | 1 | -84.18% .. -54.84% | [est.] | |
| Atm;Sirt6 | Double mutant | 2 | -87.1% .. -248.66% | [est.] | |
| Atm;Terc | Double mutant | 2 | -37.70% | ||
| bax;Ku70 | Double mutant | 6 | -71.82% .. -60.00% | ||
| Bub3;Rae1 | Double mutant | 1 | -12.00% | ||
| Cdkn1a;Terc | Double mutant | 1 | -43.13% .. 62.37% | [est.] | |
| Cp;Heph | Double mutant | 1 | -83.52% .. -52.96% | [est.] | |
| Cyp27b1;Fgf23 | Double mutant | 1 | 0.00% | ||
| Dmd;mdx;Utrn | Triple mutant | 2 | 0.00% | ||
| E2f1;Rb1 | Double mutant | 4 | -66.85% .. -190.86% | [est.] | |
| Hgf;Sod1 | Double mutant | 1 | -72.22% .. -20.7% | [est.] | |
| K-ras;Mdm4 | Double mutant | 2 | -75.99% .. -216.94% | [est.] | |
| K-ras;Trp53 | Double mutant | 1 | -69.07% | ||
| Kl;Pai1 | Double mutant | 2 | -84.65% .. -241.67% | [est.] | |
| Ku70;Ku80 | Double mutant | 1 | -65.74% | ||
| Ku80;Prkdc | Double mutant | 2 | -78.31% .. -223.58% | [est.] | |
| Kv1.3;Mc4r | Double mutant | 1 | -21.43% | ||
| Mclk1;Trp53 | Double mutant | 1 | -59.51% .. 15.59% | [est.] | |
| Mdm4;Trp53 | Double mutant | 5 | -90.77% .. -259.14% | [est.] | |
| Mdx;Utrn | Double mutant | 2 | -35.83% | ||
| Mgat5;Pten | Double mutant | 4 | -55.71% .. -33.33% | ||
| Mobr;Sod1 | Double mutant | 1 | -87.95% .. -65.59% | [est.] | |
| p18;Trp53 | Double mutant | 1 | -84.65% .. -56.18% | [est.] | |
| p27;Trp53 | Double mutant | 1 | -89.27% .. -69.35% | [est.] | |
| Pink1;Snca | Double mutant | 1 | 0.18% | ||
| Prkdc;Terc | Double mutant | 1 | -59.88% | ||
| Rbm38;Trp53 | Double mutant | 2 | -84.30% .. -42.15% | ||
| Ripk3;Sod1 | Double mutant | 2 | -83.99% .. -239.78% | [est.] | |
| Shc1;Terc | Double mutant | 3 | -38.54% .. -12.44% | ||
| Sirt6;Trp53 | Double mutant | 2 | -76.32% .. -67.61% | ||
| Terc;Trp53 | Double mutant | 1 | -86.06% .. -60.22% | [est.] |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
