| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| daf-16;daf-2;T27F7.1 | Triple mutant | 1 | -51.70% | ||
| daf-16;daf-2;tag-249 | Triple mutant | 1 | -63.95% | ||
| daf-16;daf-2;tag-318 | Triple mutant | 1 | -39.46% | ||
| daf-16;daf-2;tag-332 | Triple mutant | 1 | -27.89% | ||
| daf-16;daf-2;tlf-1 | Triple mutant | 1 | -33.33% | ||
| daf-16;daf-2;top-1 | Triple mutant | 1 | -27.89% | ||
| daf-16;daf-2;ufd-1 | Triple mutant | 1 | -61.90% | ||
| daf-16;daf-2;ulp-1 | Triple mutant | 1 | -41.50% | ||
| daf-16;daf-2;vps-16 | Triple mutant | 1 | -38.10% | ||
| daf-16;daf-2;vrk-1 | Triple mutant | 1 | -41.50% | ||
| daf-16;daf-2;W01B11.3 | Triple mutant | 1 | -34.48% | ||
| daf-16;daf-2;W04G3.2 | Triple mutant | 1 | -53.06% | ||
| daf-16;daf-2;W06E11.4 | Triple mutant | 1 | -35.37% | ||
| daf-16;daf-2;wip-1 | Triple mutant | 1 | -17.01% | ||
| daf-16;daf-2;wwp-1 | Triple mutant | 1 | -36.73% | ||
| daf-16;daf-2;Y39C12A.2 | Triple mutant | 1 | -61.22% | ||
| daf-16;daf-2;Y39G10AL.3 | Triple mutant | 1 | -44.22% | ||
| daf-16;daf-2;Y39G10AR.8 | Triple mutant | 1 | -35.96% | ||
| daf-16;daf-2;Y42G9A.4 | Triple mutant | 1 | -31.29% | ||
| daf-16;daf-2;Y47G6A.10 | Triple mutant | 1 | -33.99% | ||
| daf-16;daf-2;Y47G6A.18 | Triple mutant | 1 | -41.50% | ||
| daf-16;daf-2;Y48G1A.4 | Triple mutant | 1 | -35.47% | ||
| daf-16;daf-2;Y54G2A.31 | Triple mutant | 1 | -31.29% | ||
| daf-16;daf-2;Y55F3AM.3 | Triple mutant | 1 | -37.41% | ||
| daf-16;daf-2;Y57A10A.19 | Triple mutant | 1 | -44.90% | ||
| daf-16;daf-2;Y57G11C.13 | Triple mutant | 1 | -37.41% | ||
| daf-16;daf-2;Y59A8B.2 | Triple mutant | 1 | -48.98% | ||
| daf-16;daf-2;Y61A9LA.5 | Triple mutant | 1 | -37.41% | ||
| daf-16;daf-2;Y65B4A.3 | Triple mutant | 1 | -56.46% | ||
| daf-16;daf-2;Y77E11A.7 | Triple mutant | 1 | -41.50% | ||
| daf-16;daf-2;ZC250.3 | Triple mutant | 1 | -50.34% | ||
| daf-16;daf-2;ZK973.10 | Triple mutant | 1 | -34.98% | ||
| daf-16;daf-7 | Double mutant | 4 | -28.92% .. -3.70% | ||
| daf-16;daf-9 | Double mutant | 1 | 12.55% | ||
| daf-16;ddl-1 | Double mutant | 2 | -63.46% .. -257.41% | [est.] | |
| daf-16;ddl-2 | Double mutant | 1 | -58.24% .. 69.41% | [est.] | |
| daf-16;ddl-3 | Double mutant | 2 | -64.04% .. -259.76% | [est.] | |
| daf-16;dld-1;rrf-3 | Triple mutant | 1 | 68.46% | ||
| daf-16;dpy-20 | Double mutant | 1 | -13.49% | ||
| daf-16;drp-1 | Double mutant | 1 | -37.01% | ||
| daf-16;drr-1 | Double mutant | 1 | -55.63% .. 80.0% | [est.] | |
| daf-16;drr-2 | Double mutant | 1 | -57.66% .. 71.76% | [est.] | |
| daf-16;eak-3 | Double mutant | 1 | -36.24% | ||
| daf-16;eak-7 | Double mutant | 2 | -24.49% .. -20.71% | ||
| daf-16;eat-2 | Double mutant | 5 | -3.94% .. 19.80% | ||
| daf-16;eif-1 | Double mutant | 1 | -7.56% | ||
| daf-16;eif-1;skn-1 | Triple mutant | 1 | -27.41% | ||
| daf-16;elt-6;rrf-3 | Triple mutant | 1 | -2.73% | ||
| daf-16;epc-1;rrf-3 | Triple mutant | 1 | -30.15% | ||
| daf-16;ets-4 | Double mutant | 1 | -16.00% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
