| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| aak-1;aak-2 | Double mutant | 1 | -15.12% | ||
| aak-1;aak-2;frh-1 | Triple mutant | 1 | 4.07% | ||
| aak-1;frh-1 | Double mutant | 1 | 25.00% | ||
| aak-2;atp-3 | Double mutant | 2 | -40.12% .. -33.72% | ||
| aak-2;cco-1 | Double mutant | 2 | 40.70% .. 48.26% | ||
| aak-2;chc-1 | Double mutant | 1 | -13.30% | ||
| aak-2;cyc-2.1 | Double mutant | 2 | -20.00% .. -15.87% | ||
| aak-2;daf-16 | Double mutant | 2 | -44.33% .. -27.00% | ||
| aak-2;daf-16;daf-2 | Triple mutant | 1 | -35.37% | ||
| aak-2;daf-2 | Double mutant | 7 | -14.00% .. 75.78% | ||
| aak-2;daf-2;rsks-1 | Triple mutant | 7 | 73.85% .. 175.89% | ||
| aak-2;daf-9 | Double mutant | 1 | 10.81% | ||
| aak-2;fasn-1 | Double mutant | 1 | -11.82% | ||
| aak-2;frh-1 | Double mutant | 2 | -5.23% .. 34.30% | ||
| aak-2;ifg-1 | Double mutant | 1 | 7.88% | ||
| aak-2;igf-1 | Double mutant | 1 | -12.18% | ||
| aak-2;isp-1 | Double mutant | 2 | 31.98% .. 125.58% | ||
| aak-2;let-711 | Double mutant | 1 | -14.78% | ||
| aak-2;mdt-15 | Double mutant | 1 | -39.90% | ||
| aak-2;nmur-1 | Double mutant | 1 | 23.21% | ||
| aak-2;nuo-2 | Double mutant | 2 | 22.09% .. 30.23% | ||
| aak-2;rsks-1 | Double mutant | 5 | -30.77% .. 1.13% | ||
| aak-2;sca-1 | Double mutant | 1 | -10.84% | ||
| aak-2;sod-1 | Double mutant | 2 | -45.48% .. -184.47% | [est.] | |
| aak-2;unc-70 | Double mutant | 1 | -14.78% | ||
| aak-2;xbp-1 | Double mutant | 3 | -20.00% .. 41.45% | ||
| aakb-1;daf-2 | Double mutant | 5 | 66.89% .. 101.48% | ||
| aakg-1;daf-2;rff-3 | Triple mutant | 4 | -32.13% .. -130.35% | [est.] | |
| aakg-2;daf-2;rff-3 | Triple mutant | 4 | -24.88% .. -100.94% | [est.] | |
| aakg-3;daf-2;rff-3 | Triple mutant | 4 | -28.07% .. -113.88% | [est.] | |
| aakg-4;aakg-5 | Double mutant | 2 | 7.07% .. 25.77% | ||
| aakg-4;aakg-5;daf-2 | Triple mutant | 2 | 98.99% | ||
| aakg-4;daf-2 | Double mutant | 11 | 61.76% .. 115.32% | ||
| aakg-4;daf-2;rff-3 | Triple mutant | 6 | -42.0% .. -170.35% | [est.] | |
| aakg-4;daf-2;rsks-1 | Triple mutant | 2 | 90.63% .. 91.18% | ||
| aakg-4;rrf-3 | Double mutant | 4 | -70.13% .. -284.47% | [est.] | |
| aakg-4;rsks-1 | Double mutant | 2 | 3.12% .. 10.29% | ||
| aakg-5;daf-2 | Double mutant | 3 | 74.23% .. 104.04% | ||
| aakg-5;daf-2;rff-3 | Triple mutant | 5 | -48.38% .. -196.24% | [est.] | |
| aakg-5;rrf-3 | Double mutant | 1 | -65.2% .. 41.18% | [est.] | |
| aap-1;asm-3 | Double mutant | 1 | 48.87% .. 503.88% | [est.] | |
| aat-2;daf-16;rrf-3 | Triple mutant | 1 | -23.27% | ||
| abu-11;daf-2 | Double mutant | 4 | 40.20% .. 123.04% | ||
| acdh-13;daf-16;rrf-3 | Triple mutant | 1 | 12.19% | ||
| aco-2;daf-2 | Double mutant | 2 | 35.06% .. 142.24% | [est.] | |
| acs-5;daf-16;rrf-3 | Triple mutant | 1 | -13.73% | ||
| ada-2;daf-16;daf-2 | Triple mutant | 1 | -41.50% | ||
| ada-2;daf-2 | Double mutant | 1 | 95.92% | ||
| age-1;akt-1;sqt-1 | Triple mutant | 1 | 83.33% | ||
| age-1;asm-3 | Double mutant | 1 | 258.76% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
