| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| daf-2;pmk-1 | Double mutant | 1 | 28.22% | ||
| daf-2;pmq-1 | Double mutant | 2 | 39.76% .. 125.40% | ||
| daf-2;pnk-1 | Double mutant | 1 | 54.42% | ||
| daf-2;pptr-1 | Double mutant | 2 | 25.21% .. 28.69% | ||
| daf-2;pqm-1 | Double mutant | 2 | 44.91% .. 44.91% | ||
| daf-2;prmt-1 | Double mutant | 4 | 141.06% .. 142.24% | ||
| daf-2;prmt-1;prmt-1 | Triple mutant | 4 | -38.52% .. -156.24% | [est.] | |
| daf-2;ptr-23 | Double mutant | 1 | 61.90% | ||
| daf-2;R11A5.4 | Double mutant | 2 | 42.69% .. 173.18% | [est.] | |
| daf-2;R12B2.6 | Double mutant | 1 | 99.32% | ||
| daf-2;R53.4 | Double mutant | 1 | 162.56% | ||
| daf-2;rab-10 | Double mutant | 1 | 13.98% .. 362.35% | [est.] | |
| daf-2;rab-7 | Double mutant | 1 | 34.01% | ||
| daf-2;raga-1 | Double mutant | 5 | -25.75% .. -104.47% | [est.] | |
| daf-2;rff-3 | Double mutant | 6 | -23.72% .. -96.24% | [est.] | |
| daf-2;rha-2 | Double mutant | 1 | 46.75% .. 495.29% | [est.] | |
| daf-2;ril-1 | Double mutant | 1 | 58.64% .. 543.53% | [est.] | |
| daf-2;ril-2 | Double mutant | 1 | 68.21% .. 582.35% | [est.] | |
| daf-2;rpn-1 | Double mutant | 1 | -27.54% | ||
| daf-2;rpn-10 | Double mutant | 1 | 57.49% | ||
| daf-2;rpn-11 | Double mutant | 1 | -24.64% | ||
| daf-2;rpn-12 | Double mutant | 1 | 77.29% | ||
| daf-2;rpn-2 | Double mutant | 1 | -26.09% | ||
| daf-2;rpn-3 | Double mutant | 1 | -21.26% | ||
| daf-2;rpn-5 | Double mutant | 1 | 70.53% | ||
| daf-2;rpn-6 | Double mutant | 1 | -35.27% | ||
| daf-2;rpn-7 | Double mutant | 1 | -31.40% | ||
| daf-2;rpn-8 | Double mutant | 1 | -23.67% | ||
| daf-2;rpn-9 | Double mutant | 1 | 55.56% | ||
| daf-2;rps-15 | Double mutant | 3 | -8.35% .. -33.88% | [est.] | |
| daf-2;rps-22 | Double mutant | 3 | -5.74% .. -23.29% | [est.] | |
| daf-2;rpt-1 | Double mutant | 1 | -27.54% | ||
| daf-2;rpt-2 | Double mutant | 1 | 60.39% | ||
| daf-2;rpt-3 | Double mutant | 1 | -22.71% | ||
| daf-2;rpt-4 | Double mutant | 1 | -24.64% | ||
| daf-2;rpt-5 | Double mutant | 1 | -27.05% | ||
| daf-2;rpt-6 | Double mutant | 1 | -23.67% | ||
| daf-2;rrf-3 | Double mutant | 11 | 88.94% | ||
| daf-2;rrf-3;skn-1 | Triple mutant | 1 | 26.37% | ||
| daf-2;rrf-3;sod-3 | Triple mutant | 1 | -4.87% .. 285.88% | [est.] | |
| daf-2;rrf-3;T20G5.8 | Triple mutant | 1 | 11.37% .. 351.76% | [est.] | |
| daf-2;rsks-1 | Double mutant | 32 | 103.13% .. 454.40% | ||
| daf-2;rsks-1;tax-6 | Triple mutant | 2 | 141.21% .. 188.70% | ||
| daf-2;rsks-1;ubl-5 | Triple mutant | 3 | 64.97% .. 82.83% | ||
| daf-2;sams-1 | Double mutant | 1 | 71.69% .. 596.47% | [est.] | |
| daf-2;sca-1 | Double mutant | 1 | 96.06% | ||
| daf-2;scl-1 | Double mutant | 1 | 34.75% | ||
| daf-2;sdc-2 | Double mutant | 1 | 119.73% | ||
| daf-2;sea-2 | Double mutant | 1 | 112.14% | ||
| daf-2;sem-5 | Double mutant | 2 | 46.02% .. 55.68% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
