| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| daf-2;mes-4 | Double mutant | 3 | 59.49% .. 119.47% | ||
| daf-2;mml-1 | Double mutant | 1 | 83.78% | ||
| daf-2;mpk-1 | Double mutant | 1 | 17.92% .. 378.35% | [est.] | |
| daf-2;mxl-1 | Double mutant | 1 | 225.00% | ||
| daf-2;mxl-2 | Double mutant | 3 | 40.00% .. 86.49% | ||
| daf-2;nhl-1 | Double mutant | 1 | 105.76% | ||
| daf-2;nhr-49 | Double mutant | 8 | -5.78% .. 150.89% | ||
| daf-2;nhr-62 | Double mutant | 2 | 136.69% .. 218.44% | ||
| daf-2;nhr-8 | Double mutant | 1 | 27.65% | ||
| daf-2;nhr-80 | Double mutant | 2 | 13.11% .. 53.18% | [est.] | |
| daf-2;nit-1 | Double mutant | 1 | -37.35% .. 154.12% | [est.] | |
| daf-2;nmur-1 | Double mutant | 2 | 106.78% .. 216.38% | ||
| daf-2;npa-1 | Double mutant | 1 | 35.73% .. 450.59% | [est.] | |
| daf-2;npp-2 | Double mutant | 1 | 58.50% | ||
| daf-2;npp-3 | Double mutant | 1 | 65.99% | ||
| daf-2;npr-1 | Double mutant | 3 | 88.99% .. 150.63% | ||
| daf-2;nsh-1 | Double mutant | 1 | 58.50% | ||
| daf-2;nspb-7 | Double mutant | 1 | -14.44% .. 247.06% | [est.] | |
| daf-2;ntl-3 | Double mutant | 1 | 43.54% | ||
| daf-2;nuo-2 | Double mutant | 1 | 40.66% .. 470.59% | [est.] | |
| daf-2;nuo-3 | Double mutant | 1 | 89.1% .. 667.06% | [est.] | |
| daf-2;nuo-4 | Double mutant | 1 | 103.31% .. 724.71% | [est.] | |
| daf-2;nuo-5 | Double mutant | 1 | 68.79% .. 584.71% | [est.] | |
| daf-2;nuo-6 | Double mutant | 2 | 155.68% .. 164.32% | ||
| daf-2;odr-3 | Double mutant | 1 | 175.56% | ||
| daf-2;oga-1 | Double mutant | 1 | 35.85% | ||
| daf-2;ogt-1 | Double mutant | 1 | -16.98% | ||
| daf-2;osm-3 | Double mutant | 1 | 112.77% | ||
| daf-2;par-4 | Double mutant | 1 | 27.32% | ||
| daf-2;par-5 | Double mutant | 3 | 90.00% .. 232.43% | ||
| daf-2;pas-1 | Double mutant | 1 | 63.29% | ||
| daf-2;pas-5 | Double mutant | 1 | -24.15% | ||
| daf-2;pas-6 | Double mutant | 1 | -34.78% | ||
| daf-2;pas-7 | Double mutant | 1 | 64.25% | ||
| daf-2;pat-4 | Double mutant | 1 | 39.5% .. 465.88% | [est.] | |
| daf-2;pat-6 | Double mutant | 1 | 45.88% .. 491.76% | [est.] | |
| daf-2;pbs-2 | Double mutant | 1 | -37.20% | ||
| daf-2;pbs-3 | Double mutant | 1 | -42.51% | ||
| daf-2;pbs-4 | Double mutant | 1 | -41.06% | ||
| daf-2;pbs-5 | Double mutant | 1 | -39.61% | ||
| daf-2;pbs-6 | Double mutant | 1 | -18.36% | ||
| daf-2;pbs-7 | Double mutant | 1 | -40.10% | ||
| daf-2;pek-1 | Double mutant | 7 | 38.24% .. 176.37% | ||
| daf-2;pep-2 | Double mutant | 2 | 134.56% .. 248.18% | ||
| daf-2;pgl-1 | Double mutant | 3 | 56.92% .. 120.46% | ||
| daf-2;pgl-2 | Double mutant | 3 | 53.60% .. 126.84% | ||
| daf-2;pgl-3 | Double mutant | 3 | 58.08% .. 140.43% | ||
| daf-2;pgp-7 | Double mutant | 1 | -24.88% .. 204.71% | [est.] | |
| daf-2;pha-4 | Double mutant | 3 | 43.26% .. 119.59% | ||
| daf-2;pie-1 | Double mutant | 3 | 50.12% .. 112.68% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
