| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| daf-2;sgk-1 | Double mutant | 1 | 144.90% | ||
| daf-2;shc-1 | Double mutant | 1 | 41.26% | ||
| daf-2;sinh-1 | Double mutant | 1 | -24.01% .. 208.24% | [est.] | |
| daf-2;sir-2.1 | Double mutant | 2 | 171.35% | ||
| daf-2;skn-1 | Double mutant | 30 | -38.01% .. 88.85% | ||
| daf-2;skr-1 | Double mutant | 7 | -36.19% .. -146.82% | [est.] | |
| daf-2;skr-11 | Double mutant | 2 | -26.62% .. -108.0% | [est.] | |
| daf-2;skr-12 | Double mutant | 2 | -20.53% .. -83.29% | [est.] | |
| daf-2;skr-13 | Double mutant | 2 | -24.3% .. -98.59% | [est.] | |
| daf-2;skr-15 | Double mutant | 1 | -13.86% .. 249.41% | [est.] | |
| daf-2;skr-19 | Double mutant | 2 | -21.4% .. -86.82% | [est.] | |
| daf-2;skr-2 | Double mutant | 7 | -53.6% .. -217.41% | [est.] | |
| daf-2;skr-20 | Double mutant | 2 | -23.72% .. -96.24% | [est.] | |
| daf-2;skr-3 | Double mutant | 2 | -18.21% .. -73.88% | [est.] | |
| daf-2;skr-5 | Double mutant | 1 | -16.47% .. 238.82% | [est.] | |
| daf-2;skr-7 | Double mutant | 2 | -23.72% .. -96.24% | [est.] | |
| daf-2;skr-8 | Double mutant | 2 | -19.66% .. -79.76% | [est.] | |
| daf-2;smk-1 | Double mutant | 2 | 44.90% .. 45.36% | ||
| daf-2;smn-1 | Double mutant | 1 | 54.42% | ||
| daf-2;sod-1;sod-2;sod-3;sod-4;sod-5 | 6-mutant | 1 | 154.02% | ||
| daf-2;sod-2 | Double mutant | 2 | 80.62% .. 258.76% | ||
| daf-2;sod-2;sod-3 | Triple mutant | 1 | 148.02% | ||
| daf-2;sod-3 | Double mutant | 1 | 152.42% | ||
| daf-2;sod-4 | Double mutant | 1 | 180.62% | ||
| daf-2;sos-1 | Double mutant | 2 | 68.18% .. 69.32% | ||
| daf-2;spl-1 | Double mutant | 1 | -5.44% | ||
| daf-2;T14G10.1 | Double mutant | 1 | 79.59% | ||
| daf-2;T19B10.2 | Double mutant | 1 | -27.89% | ||
| daf-2;T22B11.2 | Double mutant | 1 | 95.92% | ||
| daf-2;T27F7.1 | Double mutant | 1 | 44.22% | ||
| daf-2;tag-249 | Double mutant | 1 | -51.02% | ||
| daf-2;tag-318 | Double mutant | 1 | 88.44% | ||
| daf-2;tag-332 | Double mutant | 1 | 90.48% | ||
| daf-2;tcer-1 | Double mutant | 10 | 87.43% | ||
| daf-2;tlf-1 | Double mutant | 1 | 31.29% | ||
| daf-2;top-1 | Double mutant | 1 | 51.02% | ||
| daf-2;trpa-1 | Double mutant | 2 | 74.11% .. 117.21% | ||
| daf-2;ttr-1 | Double mutant | 1 | 27.9% .. 418.82% | [est.] | |
| daf-2;tub-1 | Double mutant | 1 | 126.43% | ||
| daf-2;ubc-18 | Double mutant | 2 | 75.27% .. 86.63% | ||
| daf-2;ufd-1 | Double mutant | 1 | -15.65% | ||
| daf-2;ugt-9 | Double mutant | 2 | 101.29% .. 139.29% | ||
| daf-2;ulp-1 | Double mutant | 1 | 100.68% | ||
| daf-2;unc-31 | Double mutant | 1 | 95.83% | ||
| daf-2;unc-51 | Double mutant | 2 | 79.91% .. 92.69% | ||
| daf-2;unc-64 | Double mutant | 1 | 145.83% | ||
| daf-2;unc-70 | Double mutant | 1 | 134.48% | ||
| daf-2;utx-1 | Double mutant | 4 | 71.43% .. 205.01% | ||
| daf-2;vang-1 | Double mutant | 1 | 150.98% | ||
| daf-2;vhl-1 | Double mutant | 2 | 50.00% .. 157.14% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
