| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| fat-3;fem-1;fer-15 | Triple mutant | 1 | -64.91% .. 42.35% | [est.] | |
| fat-5;fat-6;glp-1 | Triple mutant | 2 | -55.05% .. -223.29% | [est.] | |
| fat-5;fat-7;glp-1 | Triple mutant | 2 | -50.7% .. -205.65% | [est.] | |
| fat-5;fem-1;fer-15 | Triple mutant | 1 | -60.27% .. 61.18% | [est.] | |
| fat-5;glp-1 | Double mutant | 2 | -31.84% .. -129.18% | [est.] | |
| fat-6;glp-1 | Double mutant | 2 | -39.1% .. -158.59% | [est.] | |
| fat-7;fem-1;fer-15 | Triple mutant | 1 | -57.37% .. 72.94% | [est.] | |
| fat-7;glp-1 | Double mutant | 2 | -39.1% .. -158.59% | [est.] | |
| fem-1;fer-15 | Double mutant | 33 | -7.42% .. 21.71% | ||
| fem-1;fer-15;gcy-18 | Triple mutant | 1 | -52.44% .. 92.94% | [est.] | |
| fem-1;fer-15;gei-9 | Triple mutant | 2 | -31.55% .. -128.0% | [est.] | |
| fem-1;fer-15;gpd-2 | Triple mutant | 1 | -59.11% .. 65.88% | [est.] | |
| fem-1;fer-15;gpi-1 | Triple mutant | 1 | -53.6% .. 88.24% | [est.] | |
| fem-1;fer-15;hsp-12.6 | Triple mutant | 1 | -57.08% .. 74.12% | [est.] | |
| fem-1;fer-15;ifg-1 | Triple mutant | 3 | -27.78% .. -112.71% | [est.] | |
| fem-1;fer-15;iftb-1 | Triple mutant | 4 | -50.99% .. -206.82% | [est.] | |
| fem-1;fer-15;ins-7 | Triple mutant | 1 | -52.44% .. 92.94% | [est.] | |
| fem-1;fer-15;inx-8 | Triple mutant | 2 | -17.92% .. -72.71% | [est.] | |
| fem-1;fer-15;ire-1 | Triple mutant | 2 | -59.11% .. -239.76% | [est.] | |
| fem-1;fer-15;lbp-7 | Triple mutant | 1 | -59.11% .. 65.88% | [est.] | |
| fem-1;fer-15;let-363 | Triple mutant | 2 | -47.22% .. -191.53% | [est.] | |
| fem-1;fer-15;lin-35 | Triple mutant | 1 | -60.56% .. 60.0% | [est.] | |
| fem-1;fer-15;lys-8 | Triple mutant | 1 | -60.85% .. 58.82% | [est.] | |
| fem-1;fer-15;maoc-1 | Triple mutant | 1 | -47.22% .. 114.12% | [est.] | |
| fem-1;fer-15;mekk-3 | Triple mutant | 2 | -30.48% .. -123.65% | [est.] | |
| fem-1;fer-15;mtl-1 | Triple mutant | 1 | -61.72% .. 55.29% | [est.] | |
| fem-1;fer-15;nuo-2 | Triple mutant | 1 | -44.9% .. 123.53% | [est.] | |
| fem-1;fer-15;nuo-3 | Triple mutant | 1 | -18.5% .. 230.59% | [est.] | |
| fem-1;fer-15;nuo-4 | Triple mutant | 1 | -25.75% .. 201.18% | [est.] | |
| fem-1;fer-15;nuo-5 | Triple mutant | 2 | -32.42% .. -131.53% | [est.] | |
| fem-1;fer-15;pat-4 | Triple mutant | 2 | -27.2% .. -110.35% | [est.] | |
| fem-1;fer-15;pat-6 | Triple mutant | 2 | -42.58% .. -172.71% | [est.] | |
| fem-1;fer-15;pep-2 | Triple mutant | 1 | -69.26% .. 24.71% | [est.] | |
| fem-1;fer-15;pes-2 | Triple mutant | 1 | -57.08% .. 74.12% | [est.] | |
| fem-1;fer-15;rab-10 | Triple mutant | 1 | -26.62% .. 197.65% | [est.] | |
| fem-1;fer-15;rha-2 | Triple mutant | 2 | -32.71% .. -132.71% | [est.] | |
| fem-1;fer-15;ril-1 | Triple mutant | 2 | -17.05% .. -69.18% | [est.] | |
| fem-1;fer-15;ril-2 | Triple mutant | 2 | -27.49% .. -111.53% | [est.] | |
| fem-1;fer-15;ril-3 | Triple mutant | 1 | -24.59% .. 205.88% | [est.] | |
| fem-1;fer-15;rpl-19 | Triple mutant | 1 | -48.67% .. 108.24% | [est.] | |
| fem-1;fer-15;rpl-30 | Triple mutant | 1 | -26.91% .. 196.47% | [est.] | |
| fem-1;fer-15;rpl-4 | Triple mutant | 1 | -47.22% .. 114.12% | [est.] | |
| fem-1;fer-15;rpl-9 | Triple mutant | 1 | -32.42% .. 174.12% | [est.] | |
| fem-1;fer-15;rps-10 | Triple mutant | 1 | -46.06% .. 118.82% | [est.] | |
| fem-1;fer-15;rps-11 | Triple mutant | 1 | -18.79% .. 229.41% | [est.] | |
| fem-1;fer-15;rps-15 | Triple mutant | 1 | -11.25% .. 260.0% | [est.] | |
| fem-1;fer-15;rps-22 | Triple mutant | 2 | -43.74% .. -177.41% | [est.] | |
| fem-1;fer-15;rps-26 | Triple mutant | 1 | -44.32% .. 125.88% | [est.] | |
| fem-1;fer-15;rps-6 | Triple mutant | 1 | -21.4% .. 218.82% | [est.] | |
| fem-1;fer-15;rsks-1 | Triple mutant | 2 | -28.07% .. -113.88% | [est.] |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
