| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| eat-2;rrf-3 | Double mutant | 2 | -44.03% .. -178.59% | [est.] | |
| eat-2;rsks-1 | Double mutant | 3 | -37.06% .. -150.35% | [est.] | |
| eat-2;sams-1 | Double mutant | 2 | -22.56% .. -91.53% | [est.] | |
| eat-2;sca-1 | Double mutant | 1 | 2.96% | ||
| eat-2;sir-2.1 | Double mutant | 8 | 2.20% .. 13.58% | ||
| eat-2;skn-1 | Double mutant | 2 | -28.21% .. -19.17% | ||
| eat-2;skr-1 | Double mutant | 2 | -30.97% .. -125.65% | [est.] | |
| eat-2;skr-2 | Double mutant | 2 | -24.88% .. -100.94% | [est.] | |
| eat-2;smk-1 | Double mutant | 1 | -6.40% | ||
| eat-2;sod-2 | Double mutant | 1 | 131.64% | ||
| eat-2;tcer-1 | Double mutant | 5 | -25.46% .. -103.29% | [est.] | |
| eat-2;ubc-18 | Double mutant | 6 | -5.53% .. 6.99% | ||
| eat-2;ubc-18;wwp-1 | Triple mutant | 2 | -46.06% .. -186.82% | [est.] | |
| eat-2;unc-70 | Double mutant | 1 | 21.18% | ||
| eat-2;utx-1 | Double mutant | 2 | 29.28% .. 43.27% | ||
| eat-2;vps-34 | Double mutant | 4 | -35.51% .. | ||
| eat-2;W01B11.3 | Double mutant | 1 | 51.72% | ||
| eat-2;wwp-1 | Double mutant | 9 | -9.57% .. -0.58% | ||
| eat-2;Y39G10AR.8 | Double mutant | 1 | 48.77% | ||
| eat-2;Y47G6A.10 | Double mutant | 1 | 40.89% | ||
| eat-2;Y48G1A.4 | Double mutant | 1 | 34.48% | ||
| eat-2;ZK973.10 | Double mutant | 1 | 46.80% | ||
| egl-1;frh-1 | Double mutant | 1 | 53.37% | ||
| egl-1;isp-1 | Double mutant | 4 | 59.24% .. 69.93% | ||
| egl-1;nuo-6 | Double mutant | 3 | 50.70% .. 57.76% | ||
| egl-3;gcy-35;npr-1 | Triple mutant | 3 | -56.35% .. -228.59% | [est.] | |
| egl-9;gcy-35;npr-1 | Triple mutant | 3 | 32.12% .. 61.28% | ||
| egl-9;hif-1 | Double mutant | 1 | -4.00% | ||
| egl-9;isp-1 | Double mutant | 1 | 38.65% | ||
| egl-9;npr-1 | Double mutant | 3 | -29.86% .. -19.51% | ||
| egl-9;rsks-1 | Double mutant | 1 | 1.43% | ||
| eif-1;glp-1 | Double mutant | 4 | 49.69% .. 53.23% | ||
| eif-1;kri-1 | Double mutant | 3 | 13.90% .. 31.61% | ||
| eif-1;skn-1 | Double mutant | 1 | -1.11% | ||
| eif-1A;skn-1 | Double mutant | 1 | -2.96% | ||
| elpc-4;rrf-3 | Double mutant | 1 | -32.71% .. 172.94% | [est.] | |
| elt-3;isp-1 | Double mutant | 1 | -13.72% .. 250.0% | [est.] | |
| ets-4;skn-1 | Double mutant | 2 | 36.43% .. 37.70% | ||
| F07A5.1;rrf-3;sir-2.1 | Triple mutant | 1 | -57.54% .. 72.24% | [est.] | |
| F09F7.5;rrf-3;sir-2.1 | Triple mutant | 1 | -62.82% .. 50.82% | [est.] | |
| F15E6.1;rrf-3;sir-2.1 | Triple mutant | 1 | -57.8% .. 71.18% | [est.] | |
| F21H12.1;rrf-3;sir-2.1 | Triple mutant | 1 | -56.7% .. 75.65% | [est.] | |
| F48C1.8;rrf-3 | Double mutant | 2 | -37.65% .. -152.71% | [est.] | |
| F54C4.2;rrf-3;sir-2.1 | Triple mutant | 1 | -51.86% .. 95.29% | [est.] | |
| F54H12.1;rrf-3;sir-2.1 | Triple mutant | 1 | -47.24% .. 114.0% | [est.] | |
| F55B11.1;rrf-3;sir-2.1 | Triple mutant | 1 | -66.47% .. 36.0% | [est.] | |
| fasn-1;ifg-1 | Double mutant | 2 | -1.48% .. -0.85% | ||
| fasn-1;isp-1 | Double mutant | 1 | 48.28% | ||
| fasn-1;rsks-1 | Double mutant | 1 | -6.90% | ||
| fat-2;glp-1 | Double mutant | 2 | 76.92% .. 107.69% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
