| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| fem-1;fer-15;sams-1 | Triple mutant | 1 | -28.94% .. 188.24% | [est.] | |
| fem-1;fer-15;sinh-1 | Triple mutant | 1 | -47.8% .. 111.76% | [est.] | |
| fem-1;fer-15;ttr-1 | Triple mutant | 2 | -30.68% .. -124.47% | [est.] | |
| fem-1;fer-15;vit-2 | Triple mutant | 1 | -55.34% .. 81.18% | [est.] | |
| fem-1;fer-15;vit-4 | Triple mutant | 1 | -63.75% .. 47.06% | [est.] | |
| fem-1;fer-15;vit-5 | Triple mutant | 1 | -53.89% .. 87.06% | [est.] | |
| fem-1;fer-15;vps-34 | Triple mutant | 4 | -8.30% .. 2.18% | ||
| fem-1;fer-15;xbp-1 | Triple mutant | 1 | -60.27% .. 61.18% | [est.] | |
| fem-1;fer-15;zig-6 | Triple mutant | 2 | -49.25% .. -199.76% | [est.] | |
| fer-15;shc-1 | Double mutant | 2 | -69.55% .. -282.12% | [est.] | |
| flr-4;gld-1 | Double mutant | 1 | 17.31% | ||
| flr-4;glp-1 | Double mutant | 1 | 33.02% | ||
| flr-4;glp-4 | Double mutant | 1 | 14.88% | ||
| flr-4;nhr-8 | Double mutant | 2 | -24.14% .. 9.12% | ||
| flr-4;nsy-1 | Double mutant | 2 | -13.03% .. 6.72% | ||
| flr-4;pha-4;smg-1 | Triple mutant | 1 | -27.87% .. 192.59% | [est.] | |
| flr-4;pmk-1 | Double mutant | 1 | 5.39% | ||
| flr-4;pmk-3 | Double mutant | 1 | 51.94% | ||
| flr-4;rde-1 | Double mutant | 1 | -55.25% .. 81.53% | [est.] | |
| flr-4;rrf-3 | Double mutant | 1 | -15.95% .. 240.94% | [est.] | |
| flr-4;sek-1 | Double mutant | 3 | -3.53% .. 6.83% | ||
| flr-4;sid-1 | Double mutant | 1 | -50.2% .. 102.0% | [est.] | |
| flr-4;skn-1 | Double mutant | 1 | 12.19% | ||
| flr-4;smg-1 | Double mutant | 2 | 5.92% .. 329.65% | [est.] | |
| flr-4;tir-1 | Double mutant | 1 | 13.72% | ||
| flr-4;unc-43 | Double mutant | 1 | -8.86% | ||
| frh-1;kin-29 | Double mutant | 1 | -1.83% | ||
| frh-1;mml-1 | Double mutant | 1 | 19.51% | ||
| frh-1;par-4 | Double mutant | 1 | 23.26% | ||
| frh-1;sad-1 | Double mutant | 1 | 26.83% | ||
| frh-1;sir-2.1 | Double mutant | 1 | 37.73% | ||
| frh-1;skn-1 | Double mutant | 2 | 25.00% .. 27.04% | ||
| ftn-1;ftn-2 | Double mutant | 3 | -1.83% .. 7.00% | ||
| ftn-1;ftn-2;gas-1 | Triple mutant | 1 | -33.73% | ||
| ftn-1;ftn-2;isp-1 | Triple mutant | 3 | -3.08% .. 48.10% | ||
| ftn-1;ftn-2;mev-1 | Triple mutant | 3 | -40.29% .. -17.73% | ||
| ftn-1;ftn-2;nuo-6 | Triple mutant | 1 | -8.21% | ||
| ftt-1;pdk-1 | Double mutant | 2 | 3.17% .. 30.69% | ||
| ftt-2;hcf-1 | Double mutant | 7 | -33.33% .. 28.48% | ||
| ftt-2;pdk-1 | Double mutant | 2 | -6.88% .. 13.76% | ||
| ftt-2;sir-2.1 | Double mutant | 5 | -30.00% .. -0.60% | ||
| ftt-2gs;hcf-1 | Double mutant | 1 | 7.53% | ||
| gas-1;mekk-3 | Double mutant | 2 | 56.36% .. 101.09% | ||
| gcy-18;rrf-3 | Double mutant | 2 | -45.77% .. -185.65% | [est.] | |
| gcy-33;gcy-35;npr-1 | Triple mutant | 3 | -26.89% .. -13.29% | ||
| gcy-33;npr-1 | Double mutant | 5 | -32.29% .. 10.50% | ||
| gcy-35;hif-1;npr-1 | Triple mutant | 3 | -24.64% .. -17.38% | ||
| gcy-35;npr-1 | Double mutant | 34 | -15.10% .. 78.68% | ||
| gcy-35;npr-1;tax-4 | Triple mutant | 4 | -7.34% .. 6.54% | ||
| gcy-6;rrf-3 | Double mutant | 1 | -45.19% .. 122.35% | [est.] |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
