| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| daf-2;tag-332 | Caenorhabditis elegans | Double mutant | 1 | 90.48% | ||
| daf-2;tcer-1 | Caenorhabditis elegans | Double mutant | 10 | 87.43% | ||
| daf-2;tlf-1 | Caenorhabditis elegans | Double mutant | 1 | 31.29% | ||
| daf-2;top-1 | Caenorhabditis elegans | Double mutant | 1 | 51.02% | ||
| daf-2;trpa-1 | Caenorhabditis elegans | Double mutant | 2 | 74.11% .. 117.21% | ||
| daf-2;ttr-1 | Caenorhabditis elegans | Double mutant | 1 | 27.9% .. 418.82% | [est.] | |
| daf-2;tub-1 | Caenorhabditis elegans | Double mutant | 1 | 126.43% | ||
| daf-2;ubc-18 | Caenorhabditis elegans | Double mutant | 2 | 75.27% .. 86.63% | ||
| daf-2;ufd-1 | Caenorhabditis elegans | Double mutant | 1 | -15.65% | ||
| daf-2;ugt-9 | Caenorhabditis elegans | Double mutant | 2 | 101.29% .. 139.29% | ||
| daf-2;ulp-1 | Caenorhabditis elegans | Double mutant | 1 | 100.68% | ||
| daf-2;unc-31 | Caenorhabditis elegans | Double mutant | 1 | 95.83% | ||
| daf-2;unc-51 | Caenorhabditis elegans | Double mutant | 2 | 79.91% .. 92.69% | ||
| daf-2;unc-64 | Caenorhabditis elegans | Double mutant | 1 | 145.83% | ||
| daf-2;unc-70 | Caenorhabditis elegans | Double mutant | 1 | 134.48% | ||
| daf-2;utx-1 | Caenorhabditis elegans | Double mutant | 4 | 71.43% .. 205.01% | ||
| daf-2;vang-1 | Caenorhabditis elegans | Double mutant | 1 | 150.98% | ||
| daf-2;vhl-1 | Caenorhabditis elegans | Double mutant | 2 | 50.00% .. 157.14% | ||
| daf-2;vps-16 | Caenorhabditis elegans | Double mutant | 1 | 61.90% | ||
| daf-2;vrk-1 | Caenorhabditis elegans | Double mutant | 1 | 19.05% | ||
| daf-2;W01B11.3 | Caenorhabditis elegans | Double mutant | 1 | 151.72% | ||
| daf-2;W04G3.2 | Caenorhabditis elegans | Double mutant | 1 | -27.21% | ||
| daf-2;W06E11.4 | Caenorhabditis elegans | Double mutant | 1 | 100.00% | ||
| daf-2;wip-1 | Caenorhabditis elegans | Double mutant | 1 | 72.11% | ||
| daf-2;wwp-1 | Caenorhabditis elegans | Double mutant | 2 | 97.28% | ||
| daf-2;xbp-1 | Caenorhabditis elegans | Double mutant | 19 | -7.92% .. 156.99% | ||
| daf-2;Y39C12A.2 | Caenorhabditis elegans | Double mutant | 1 | -16.33% | ||
| daf-2;Y39G10AL.3 | Caenorhabditis elegans | Double mutant | 1 | 95.92% | ||
| daf-2;Y39G10AR.8 | Caenorhabditis elegans | Double mutant | 1 | 135.47% | ||
| daf-2;Y42G9A.4 | Caenorhabditis elegans | Double mutant | 1 | 74.15% | ||
| daf-2;Y47G6A.10 | Caenorhabditis elegans | Double mutant | 1 | 139.41% | ||
| daf-2;Y47G6A.18 | Caenorhabditis elegans | Double mutant | 1 | 85.71% | ||
| daf-2;Y48G1A.4 | Caenorhabditis elegans | Double mutant | 1 | 132.51% | ||
| daf-2;Y54G2A.31 | Caenorhabditis elegans | Double mutant | 1 | 92.52% | ||
| daf-2;Y55F3AM.3 | Caenorhabditis elegans | Double mutant | 1 | 89.12% | ||
| daf-2;Y57A10A.19 | Caenorhabditis elegans | Double mutant | 1 | 59.18% | ||
| daf-2;Y57G11C.13 | Caenorhabditis elegans | Double mutant | 1 | 55.78% | ||
| daf-2;Y59A8B.2 | Caenorhabditis elegans | Double mutant | 1 | -2.04% | ||
| daf-2;Y61A9LA.5 | Caenorhabditis elegans | Double mutant | 1 | -8.16% | ||
| daf-2;Y65B4A.3 | Caenorhabditis elegans | Double mutant | 1 | -23.13% | ||
| daf-2;Y77E11A.7 | Caenorhabditis elegans | Double mutant | 1 | 55.10% | ||
| daf-2;ZC250.3 | Caenorhabditis elegans | Double mutant | 1 | 52.38% | ||
| daf-2;ZK973.10 | Caenorhabditis elegans | Double mutant | 1 | 119.21% | ||
| daf-3;daf-7 | Caenorhabditis elegans | Double mutant | 6 | -40.73% .. 0.65% | ||
| daf-3;daf-9 | Caenorhabditis elegans | Double mutant | 1 | 79.43% | ||
| daf-3;mekk-3 | Caenorhabditis elegans | Double mutant | 2 | 37.97% .. 52.05% | ||
| daf-5;mekk-3 | Caenorhabditis elegans | Double mutant | 2 | 42.18% .. 43.44% | ||
| daf-7;nhr-8 | Caenorhabditis elegans | Double mutant | 1 | -2.41% | ||
| daf-9;eat-2 | Caenorhabditis elegans | Double mutant | 4 | -7.32% .. -5.61% | ||
| daf-9;eat-2;let-363 | Caenorhabditis elegans | Triple mutant | 1 | -46.95% .. 115.18% | [est.] |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group