| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| eat-2;F22D6.3 | Double mutant | 1 | 43.84% | ||
| eat-2;F26E4.4 | Double mutant | 1 | 34.98% | ||
| eat-2;F59A3.3 | Double mutant | 1 | 44.83% | ||
| eat-2;F59C6.4 | Double mutant | 1 | 43.84% | ||
| eat-2;F59C6.5 | Double mutant | 1 | 38.92% | ||
| eat-2;fasn-1 | Double mutant | 1 | -6.40% | ||
| eat-2;flr-4;rrf-3 | Triple mutant | 1 | -24.04% .. 208.12% | [est.] | |
| eat-2;hif-1 | Double mutant | 2 | 20.48% .. 70.89% | ||
| eat-2;ife-2 | Double mutant | 1 | 49.45% | ||
| eat-2;ifg-1 | Double mutant | 4 | 72.41% | ||
| eat-2;iftb-1 | Double mutant | 2 | -22.27% .. -90.35% | [est.] | |
| eat-2;ire-1 | Double mutant | 4 | -14.02% .. 15.59% | ||
| eat-2;isp-1 | Double mutant | 1 | 120.67% | ||
| eat-2;K01C8.6 | Double mutant | 1 | 42.36% | ||
| eat-2;K11B4.1 | Double mutant | 1 | 44.83% | ||
| eat-2;let-363 | Double mutant | 7 | -38.31% .. -155.41% | [est.] | |
| eat-2;let-711 | Double mutant | 1 | 11.33% | ||
| eat-2;lin-15b;nhr-21;nre-1 | 4-mutant | 2 | -51.68% .. -209.65% | [est.] | |
| eat-2;lin-15b;nhr-35;nre-1 | 4-mutant | 2 | -56.55% .. -229.41% | [est.] | |
| eat-2;lin-15b;nhr-49;nre-1 | 4-mutant | 1 | -57.08% .. 74.12% | [est.] | |
| eat-2;lin-15b;nhr-4;nre-1 | 4-mutant | 1 | -42.23% .. 134.35% | [est.] | |
| eat-2;lin-15b;nhr-62;nre-1 | 4-mutant | 4 | -58.38% .. -236.82% | [est.] | |
| eat-2;lin-15b;nre-1 | Triple mutant | 5 | -56.58% .. -229.53% | [est.] | |
| eat-2;lin-15b;nre-1;pha-4 | 4-mutant | 1 | -56.26% .. 77.41% | [est.] | |
| eat-2;mdl-1 | Double mutant | 1 | 60.00% | ||
| eat-2;mdt-15 | Double mutant | 1 | -16.75% | ||
| eat-2;mekk-3 | Double mutant | 6 | 13.88% .. 72.54% | ||
| eat-2;mml-1 | Double mutant | 1 | 8.50% | ||
| eat-2;mxl-1 | Double mutant | 2 | 46.50% .. 50.00% | ||
| eat-2;mxl-2 | Double mutant | 2 | -13.05% .. -6.00% | ||
| eat-2;nhr-21 | Double mutant | 1 | 26.89% | ||
| eat-2;nhr-4 | Double mutant | 1 | 29.59% | ||
| eat-2;nhr-49 | Double mutant | 3 | -28.20% .. -24.29% | ||
| eat-2;nhr-62 | Double mutant | 4 | -2.29% .. 20.42% | ||
| eat-2;nhr-8 | Double mutant | 2 | 22.59% .. 30.98% | ||
| eat-2;nlp-7 | Double mutant | 2 | 5.13% .. 10.36% | ||
| eat-2;nuo-6 | Double mutant | 2 | 87.04% .. 134.13% | ||
| eat-2;pat-4 | Double mutant | 2 | -45.48% .. -184.47% | [est.] | |
| eat-2;pat-6 | Double mutant | 2 | -38.23% .. -155.06% | [est.] | |
| eat-2;pha-4 | Double mutant | 1 | -24.31% | ||
| eat-2;pqm-1 | Double mutant | 2 | -42.49% .. -172.35% | [est.] | |
| eat-2;prmt-1 | Double mutant | 1 | -39.68% .. 144.71% | [est.] | |
| eat-2;R53.4 | Double mutant | 1 | 61.58% | ||
| eat-2;rab-10 | Double mutant | 2 | -23.72% .. -96.24% | [est.] | |
| eat-2;raga-1 | Double mutant | 3 | -49.54% .. -200.94% | [est.] | |
| eat-2;rha-2 | Double mutant | 1 | -2.55% .. 295.29% | [est.] | |
| eat-2;ril-1 | Double mutant | 1 | 5.57% .. 328.24% | [est.] | |
| eat-2;ril-2 | Double mutant | 1 | 13.69% .. 361.18% | [est.] | |
| eat-2;rps-15 | Double mutant | 2 | -21.98% .. -89.18% | [est.] | |
| eat-2;rps-22 | Double mutant | 1 | -8.06% .. 272.94% | [est.] |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
