| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| daf-2;ftt-1 | Caenorhabditis elegans | Double mutant | 4 | -36.84% .. 34.39% | ||
| daf-2;ftt-2 | Caenorhabditis elegans | Double mutant | 9 | -55.79% .. 208.16% | ||
| daf-2;gcp-1;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | 6.15% .. 330.59% | [est.] | |
| daf-2;gcy-35;npr-1 | Caenorhabditis elegans | Triple mutant | 3 | 62.14% .. 147.58% | ||
| daf-2;gdi-1 | Caenorhabditis elegans | Double mutant | 1 | 58.50% | ||
| daf-2;gld-1 | Caenorhabditis elegans | Double mutant | 2 | 118.33% .. 125.82% | ||
| daf-2;gld-1;rsks-1 | Caenorhabditis elegans | Triple mutant | 2 | 175.56% .. 186.26% | ||
| daf-2;glf-1 | Caenorhabditis elegans | Double mutant | 1 | -31.97% | ||
| daf-2;glp-1 | Caenorhabditis elegans | Double mutant | 3 | 191.41% .. 193.85% | ||
| daf-2;glp-1;rsks-1 | Caenorhabditis elegans | Triple mutant | 2 | 213.28% .. 234.62% | ||
| daf-2;glp-4 | Caenorhabditis elegans | Double mutant | 1 | 135.46% | ||
| daf-2;gpa-1 | Caenorhabditis elegans | Double mutant | 1 | 110.56% | ||
| daf-2;gpa-11 | Caenorhabditis elegans | Double mutant | 2 | 88.33% .. 162.78% | ||
| daf-2;gpa-11;odr-3 | Caenorhabditis elegans | Triple mutant | 2 | 147.22% .. 170.00% | ||
| daf-2;gpd-2 | Caenorhabditis elegans | Double mutant | 2 | 36.31% .. 147.29% | [est.] | |
| daf-2;gpdh-1;gpdh-2 | Caenorhabditis elegans | Triple mutant | 1 | 140.65% | ||
| daf-2;gpi-1 | Caenorhabditis elegans | Double mutant | 1 | 0.06% .. 305.88% | [est.] | |
| daf-2;gro-1 | Caenorhabditis elegans | Double mutant | 1 | 117.40% | ||
| daf-2;H27M09.1 | Caenorhabditis elegans | Double mutant | 1 | 78.23% | ||
| daf-2;hcf-1 | Caenorhabditis elegans | Double mutant | 3 | 108.28% .. 174.83% | ||
| daf-2;hif-1 | Caenorhabditis elegans | Double mutant | 2 | 70.00% .. 157.35% | ||
| daf-2;his-71 | Caenorhabditis elegans | Double mutant | 1 | 83.67% | ||
| daf-2;hpk-1 | Caenorhabditis elegans | Double mutant | 1 | 55.10% | ||
| daf-2;hsf-1 | Caenorhabditis elegans | Double mutant | 6 | -61.93% .. 45.91% | ||
| daf-2;hsf-1;rsks-1 | Caenorhabditis elegans | Triple mutant | 5 | -49.24% .. -32.80% | ||
| daf-2;ife-2 | Caenorhabditis elegans | Double mutant | 1 | 156.04% | ||
| daf-2;ifg-1 | Caenorhabditis elegans | Double mutant | 4 | 120.69% | ||
| daf-2;ifta-2 | Caenorhabditis elegans | Double mutant | 1 | 47.81% | ||
| daf-2;iftb-1 | Caenorhabditis elegans | Double mutant | 3 | -21.4% .. -86.82% | [est.] | |
| daf-2;ins-18 | Caenorhabditis elegans | Double mutant | 2 | 75.00% .. 216.00% | ||
| daf-2;ire-1 | Caenorhabditis elegans | Double mutant | 15 | -6.44% .. 82.80% | ||
| daf-2;ire-1;xbp-1 | Caenorhabditis elegans | Triple mutant | 2 | -38.81% .. -157.41% | [est.] | |
| daf-2;isp-1 | Caenorhabditis elegans | Double mutant | 3 | 102.46% .. 115.82% | ||
| daf-2;isw-1 | Caenorhabditis elegans | Double mutant | 3 | 60.81% .. 108.12% | ||
| daf-2;jnk-1 | Caenorhabditis elegans | Double mutant | 1 | 202.84% | ||
| daf-2;K01C8.6 | Caenorhabditis elegans | Double mutant | 1 | 129.56% | ||
| daf-2;K04C2.5 | Caenorhabditis elegans | Double mutant | 1 | -17.34% .. 235.29% | [est.] | |
| daf-2;K10H10.4 | Caenorhabditis elegans | Double mutant | 1 | -33.58% .. 169.41% | [est.] | |
| daf-2;K11B4.1 | Caenorhabditis elegans | Double mutant | 1 | 115.76% | ||
| daf-2;K11D12.9 | Caenorhabditis elegans | Double mutant | 1 | 85.03% | ||
| daf-2;kri-1 | Caenorhabditis elegans | Double mutant | 3 | -12.12% .. -49.18% | [est.] | |
| daf-2;kri-1;rrf-3 | Caenorhabditis elegans | Triple mutant | 2 | -27.2% .. -110.35% | [est.] | |
| daf-2;kri-1;rsks-1 | Caenorhabditis elegans | Triple mutant | 2 | 16.3% .. 66.12% | [est.] | |
| daf-2;let-363 | Caenorhabditis elegans | Double mutant | 3 | -13.57% .. -55.06% | [est.] | |
| daf-2;let-60 | Caenorhabditis elegans | Double mutant | 6 | -21.59% .. 55.68% | ||
| daf-2;let-653 | Caenorhabditis elegans | Double mutant | 1 | 74.83% | ||
| daf-2;let-711 | Caenorhabditis elegans | Double mutant | 1 | 70.94% | ||
| daf-2;lgg-1 | Caenorhabditis elegans | Double mutant | 2 | 78.97% .. 79.45% | ||
| daf-2;lgg-2 | Caenorhabditis elegans | Double mutant | 2 | 91.59% .. 96.80% | ||
| daf-2;lgg-3 | Caenorhabditis elegans | Double mutant | 2 | 82.65% .. 117.76% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group