| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| glp-1;pbs-3 | Caenorhabditis elegans | Double mutant | 1 | -39.13% | ||
| glp-1;pbs-4 | Caenorhabditis elegans | Double mutant | 1 | -25.60% | ||
| glp-1;pbs-5 | Caenorhabditis elegans | Double mutant | 1 | -31.88% | ||
| glp-1;pbs-6 | Caenorhabditis elegans | Double mutant | 1 | -24.64% | ||
| glp-1;pbs-7 | Caenorhabditis elegans | Double mutant | 1 | -28.02% | ||
| glp-1;pha-4 | Caenorhabditis elegans | Double mutant | 3 | -12.38% .. -9.57% | ||
| glp-1;raga-1 | Caenorhabditis elegans | Double mutant | 4 | 31.75% .. 54.18% | ||
| glp-1;rpn-1 | Caenorhabditis elegans | Double mutant | 1 | -23.67% | ||
| glp-1;rpn-10 | Caenorhabditis elegans | Double mutant | 1 | -2.42% | ||
| glp-1;rpn-11 | Caenorhabditis elegans | Double mutant | 1 | -33.82% | ||
| glp-1;rpn-12 | Caenorhabditis elegans | Double mutant | 1 | 1.45% | ||
| glp-1;rpn-2 | Caenorhabditis elegans | Double mutant | 1 | -27.05% | ||
| glp-1;rpn-3 | Caenorhabditis elegans | Double mutant | 1 | -23.67% | ||
| glp-1;rpn-5 | Caenorhabditis elegans | Double mutant | 1 | 14.98% | ||
| glp-1;rpn-6 | Caenorhabditis elegans | Double mutant | 1 | -32.85% | ||
| glp-1;rpn-7 | Caenorhabditis elegans | Double mutant | 1 | -27.54% | ||
| glp-1;rpn-8 | Caenorhabditis elegans | Double mutant | 1 | -28.50% | ||
| glp-1;rpn-9 | Caenorhabditis elegans | Double mutant | 1 | -19.32% | ||
| glp-1;rpt-1 | Caenorhabditis elegans | Double mutant | 1 | -27.54% | ||
| glp-1;rpt-2 | Caenorhabditis elegans | Double mutant | 1 | 1.45% | ||
| glp-1;rpt-3 | Caenorhabditis elegans | Double mutant | 1 | -31.40% | ||
| glp-1;rpt-4 | Caenorhabditis elegans | Double mutant | 1 | -38.16% | ||
| glp-1;rpt-5 | Caenorhabditis elegans | Double mutant | 1 | -27.54% | ||
| glp-1;rpt-6 | Caenorhabditis elegans | Double mutant | 1 | -31.40% | ||
| glp-1;rsks-1 | Caenorhabditis elegans | Double mutant | 2 | -22.31% .. -8.59% | ||
| glp-1;sinh-1 | Caenorhabditis elegans | Double mutant | 2 | -43.45% .. -176.24% | [est.] | |
| glp-1;skr-1 | Caenorhabditis elegans | Double mutant | 3 | -37.35% .. -151.53% | [est.] | |
| glp-1;skr-11 | Caenorhabditis elegans | Double mutant | 2 | -23.43% .. -95.06% | [est.] | |
| glp-1;skr-12 | Caenorhabditis elegans | Double mutant | 2 | -26.91% .. -109.18% | [est.] | |
| glp-1;skr-13 | Caenorhabditis elegans | Double mutant | 2 | -27.2% .. -110.35% | [est.] | |
| glp-1;skr-15 | Caenorhabditis elegans | Double mutant | 2 | -24.88% .. -100.94% | [est.] | |
| glp-1;skr-19 | Caenorhabditis elegans | Double mutant | 2 | -21.4% .. -86.82% | [est.] | |
| glp-1;skr-2 | Caenorhabditis elegans | Double mutant | 2 | -35.9% .. -145.65% | [est.] | |
| glp-1;skr-20 | Caenorhabditis elegans | Double mutant | 2 | -33.58% .. -136.24% | [est.] | |
| glp-1;skr-3 | Caenorhabditis elegans | Double mutant | 2 | -26.04% .. -105.65% | [est.] | |
| glp-1;skr-5 | Caenorhabditis elegans | Double mutant | 1 | -21.4% .. 218.82% | [est.] | |
| glp-1;skr-7 | Caenorhabditis elegans | Double mutant | 2 | -23.43% .. -95.06% | [est.] | |
| glp-1;skr-8 | Caenorhabditis elegans | Double mutant | 2 | -28.94% .. -117.41% | [est.] | |
| glp-1;smk-1 | Caenorhabditis elegans | Double mutant | 1 | -66.07% .. 37.65% | [est.] | |
| glp-1;sod-2 | Caenorhabditis elegans | Double mutant | 1 | 116.95% | ||
| glp-1;tcer-1 | Caenorhabditis elegans | Double mutant | 29 | -33.17% .. 79.46% | ||
| glp-1;tcer-1;tcer-1 | Caenorhabditis elegans | Triple mutant | 5 | 39.46% .. 74.19% | ||
| glp-1;tor | Caenorhabditis elegans | Double mutant | 4 | -3.65% .. 29.19% | ||
| glp-1;ttr-1 | Caenorhabditis elegans | Double mutant | 2 | -46.93% .. -190.35% | [est.] | |
| glp-1;unc-51 | Caenorhabditis elegans | Double mutant | 3 | -12.57% .. 5.39% | ||
| glp-1;utx-1 | Caenorhabditis elegans | Double mutant | 5 | 12.44% .. 45.21% | ||
| glp-1;vha-16 | Caenorhabditis elegans | Double mutant | 4 | -21.14% .. | ||
| glp-1;vps-34 | Caenorhabditis elegans | Double mutant | 5 | -19.27% .. -0.56% | ||
| glp-4;ife-2 | Caenorhabditis elegans | Double mutant | 1 | 23.28% | ||
| glp-4;mnk-1 | Caenorhabditis elegans | Double mutant | 1 | -6.03% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group