| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| glp-4;mpk-1 | Caenorhabditis elegans | Double mutant | 1 | -7.00% | ||
| gpa-11;gpc-1 | Caenorhabditis elegans | Double mutant | 2 | 7.19% .. 25.15% | ||
| gpa-11;odr-3 | Caenorhabditis elegans | Double mutant | 6 | -11.38% .. 98.29% | ||
| gpa-1;gpa-11 | Caenorhabditis elegans | Double mutant | 2 | 1.20% .. 28.74% | ||
| gpa-1;gpc-1 | Caenorhabditis elegans | Double mutant | 1 | 21.56% | ||
| gpa-1;odr-3 | Caenorhabditis elegans | Double mutant | 1 | 27.54% | ||
| gpc-1;odr-3 | Caenorhabditis elegans | Double mutant | 1 | 21.56% | ||
| gpdh-1;gpdh-2 | Caenorhabditis elegans | Double mutant | 1 | 21.89% | ||
| hcf-1;par-5 | Caenorhabditis elegans | Double mutant | 1 | -41.94% | ||
| hcf-1;par-5gs | Caenorhabditis elegans | Double mutant | 1 | 34.41% | ||
| hcf-1;sgk-1 | Caenorhabditis elegans | Double mutant | 3 | -40.11% .. 17.65% | ||
| hcf-1;sir-2.1 | Caenorhabditis elegans | Double mutant | 27 | 3.33% .. 47.22% | ||
| HDAC1;Sirt1 | Drosophila melanogaster | Double mutant | 2 | -5.88% | ||
| hep;puc | Drosophila melanogaster | Double mutant | 1 | -38.67% .. 56.46% | [est.] | |
| Hgf;Sod1 | Mus musculus | Double mutant | 1 | -72.22% .. -20.7% | [est.] | |
| hif-1;ire-1 | Caenorhabditis elegans | Double mutant | 1 | -36.11% | ||
| hif-1;isp-1 | Caenorhabditis elegans | Double mutant | 4 | 10.42% .. 16.46% | ||
| hif-1;npr-1 | Caenorhabditis elegans | Double mutant | 3 | -22.59% .. -16.75% | ||
| hif-1;osm-5 | Caenorhabditis elegans | Double mutant | 1 | 33.33% | ||
| hif-1;pha-4 | Caenorhabditis elegans | Double mutant | 1 | 17.86% | ||
| hif-1;rsks-1 | Caenorhabditis elegans | Double mutant | 1 | 21.43% | ||
| hif-1;skn-1 | Caenorhabditis elegans | Double mutant | 1 | -26.00% | ||
| hif-1;tpk-1 | Caenorhabditis elegans | Double mutant | 1 | -15.14% .. 244.24% | [est.] | |
| hif-1;vhl-1 | Caenorhabditis elegans | Double mutant | 18 | -3.51% .. 28.20% | ||
| hif-1;xbp-1 | Caenorhabditis elegans | Double mutant | 1 | -4.03% | ||
| him-5;ins-1 | Caenorhabditis elegans | Double mutant | 1 | -69.26% .. 24.71% | [est.] | |
| hlh-30;mxl-3 | Caenorhabditis elegans | Double mutant | 1 | 5.00% | ||
| hlh-30;tor | Caenorhabditis elegans | Double mutant | 3 | -10.65% .. 4.09% | ||
| hsb-1;hsf-1 | Caenorhabditis elegans | Double mutant | 2 | -42.55% .. -39.46% | ||
| hsf-1;mekk-3 | Caenorhabditis elegans | Double mutant | 2 | 61.40% .. 94.68% | ||
| hsf-1;nmur-1 | Caenorhabditis elegans | Double mutant | 1 | -25.45% | ||
| hsf-1;old-1 | Caenorhabditis elegans | Double mutant | 1 | -27.59% | ||
| hsf-1;pkc-2 | Caenorhabditis elegans | Double mutant | 1 | -44.14% | ||
| hsf-1;ragc-1 | Caenorhabditis elegans | Double mutant | 2 | -35.83% .. -30.65% | ||
| hsf-1;rps-15 | Caenorhabditis elegans | Double mutant | 2 | -45.65% .. -19.77% | ||
| hsf-1;rps-6 | Caenorhabditis elegans | Double mutant | 2 | -34.24% .. -19.77% | ||
| hsf-1;rrf3 | Caenorhabditis elegans | Double mutant | 1 | -27.80% | ||
| hsf-1;rsks-1 | Caenorhabditis elegans | Double mutant | 9 | -65.09% .. -25.26% | ||
| hsf-1;sod-1 | Caenorhabditis elegans | Double mutant | 2 | -51.28% .. -208.0% | [est.] | |
| hsf-1;trpa-1 | Caenorhabditis elegans | Double mutant | 1 | -3.53% | ||
| hsp-16.1;hsp-16.11;hsp-16.2 | Caenorhabditis elegans | Triple mutant | 2 | -10.49% .. -5.06% | ||
| hsp-16.1;hsp-16.11;hsp-16.2;rsks-1 | Caenorhabditis elegans | 4-mutant | 2 | -7.41% .. 19.66% | ||
| hsp-70;rsks-1 | Caenorhabditis elegans | Double mutant | 2 | 7.41% .. 18.54% | ||
| ife-2;let-363 | Caenorhabditis elegans | Double mutant | 2 | 65.52% | ||
| ife-2;mnk-1 | Caenorhabditis elegans | Double mutant | 1 | 38.46% | ||
| ife-2;rps-15 | Caenorhabditis elegans | Double mutant | 2 | -35.03% .. -142.12% | [est.] | |
| ife-2;rskn-1 | Caenorhabditis elegans | Double mutant | 1 | 47.80% | ||
| ife-2;rsks-1 | Caenorhabditis elegans | Double mutant | 2 | 51.65% | ||
| ife-2;skn-1 | Caenorhabditis elegans | Double mutant | 1 | 9.81% | ||
| ifg-1;ifg-1 | Caenorhabditis elegans | Double mutant | 1 | 43.84% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group