| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| foxo;InR | Drosophila melanogaster | Double mutant | 2 | -31.34% .. -13.11% | ||
| foxo;Lrrk | Drosophila melanogaster | Double mutant | 1 | -8.24% | ||
| foxo;Pi3K92E | Drosophila melanogaster | Double mutant | 1 | -32.00% | ||
| foxo;rpr | Drosophila melanogaster | Double mutant | 1 | -26.67% | ||
| frh-1;kin-29 | Caenorhabditis elegans | Double mutant | 1 | -1.83% | ||
| frh-1;mml-1 | Caenorhabditis elegans | Double mutant | 1 | 19.51% | ||
| frh-1;par-4 | Caenorhabditis elegans | Double mutant | 1 | 23.26% | ||
| frh-1;sad-1 | Caenorhabditis elegans | Double mutant | 1 | 26.83% | ||
| frh-1;sir-2.1 | Caenorhabditis elegans | Double mutant | 1 | 37.73% | ||
| frh-1;skn-1 | Caenorhabditis elegans | Double mutant | 2 | 25.00% .. 27.04% | ||
| ftn-1;ftn-2 | Caenorhabditis elegans | Double mutant | 3 | -1.83% .. 7.00% | ||
| ftn-1;ftn-2;gas-1 | Caenorhabditis elegans | Triple mutant | 1 | -33.73% | ||
| ftn-1;ftn-2;isp-1 | Caenorhabditis elegans | Triple mutant | 3 | -3.08% .. 48.10% | ||
| ftn-1;ftn-2;mev-1 | Caenorhabditis elegans | Triple mutant | 3 | -40.29% .. -17.73% | ||
| ftn-1;ftn-2;nuo-6 | Caenorhabditis elegans | Triple mutant | 1 | -8.21% | ||
| ftt-1;pdk-1 | Caenorhabditis elegans | Double mutant | 2 | 3.17% .. 30.69% | ||
| ftt-2;hcf-1 | Caenorhabditis elegans | Double mutant | 7 | -33.33% .. 28.48% | ||
| ftt-2;pdk-1 | Caenorhabditis elegans | Double mutant | 2 | -6.88% .. 13.76% | ||
| ftt-2;sir-2.1 | Caenorhabditis elegans | Double mutant | 5 | -30.00% .. -0.60% | ||
| ftt-2gs;hcf-1 | Caenorhabditis elegans | Double mutant | 1 | 7.53% | ||
| gas-1;mekk-3 | Caenorhabditis elegans | Double mutant | 2 | 56.36% .. 101.09% | ||
| gcy-18;rrf-3 | Caenorhabditis elegans | Double mutant | 2 | -45.77% .. -185.65% | [est.] | |
| gcy-33;gcy-35;npr-1 | Caenorhabditis elegans | Triple mutant | 3 | -26.89% .. -13.29% | ||
| gcy-33;npr-1 | Caenorhabditis elegans | Double mutant | 5 | -32.29% .. 10.50% | ||
| gcy-35;hif-1;npr-1 | Caenorhabditis elegans | Triple mutant | 3 | -24.64% .. -17.38% | ||
| gcy-35;npr-1 | Caenorhabditis elegans | Double mutant | 34 | -15.10% .. 78.68% | ||
| gcy-35;npr-1;tax-4 | Caenorhabditis elegans | Triple mutant | 4 | -7.34% .. 6.54% | ||
| gcy-6;rrf-3 | Caenorhabditis elegans | Double mutant | 1 | -45.19% .. 122.35% | [est.] | |
| gld-1;rsks-1 | Caenorhabditis elegans | Double mutant | 2 | -7.14% .. -3.33% | ||
| glp-1;gpi-1 | Caenorhabditis elegans | Double mutant | 2 | -28.36% .. -115.06% | [est.] | |
| glp-1;hcf-1 | Caenorhabditis elegans | Double mutant | 1 | 57.35% | ||
| glp-1;hif-1 | Caenorhabditis elegans | Double mutant | 1 | 43.79% | ||
| glp-1;hlh-30 | Caenorhabditis elegans | Double mutant | 4 | -8.33% .. 22.92% | ||
| glp-1;ifg-1 | Caenorhabditis elegans | Double mutant | 1 | 57.50% | ||
| glp-1;kri-1 | Caenorhabditis elegans | Double mutant | 2 | -50.7% .. -205.65% | [est.] | |
| glp-1;lgg-1 | Caenorhabditis elegans | Double mutant | 3 | -35.94% .. 9.50% | ||
| glp-1;lipl-4 | Caenorhabditis elegans | Double mutant | 4 | 10.70% .. 11.68% | ||
| glp-1;lipl-4;vps-34 | Caenorhabditis elegans | Triple mutant | 2 | -54.47% .. -220.94% | [est.] | |
| glp-1;lmp-1 | Caenorhabditis elegans | Double mutant | 4 | -11.48% .. 15.82% | ||
| glp-1;maoc-1 | Caenorhabditis elegans | Double mutant | 2 | -24.01% .. -97.41% | [est.] | |
| glp-1;mekk-3 | Caenorhabditis elegans | Double mutant | 2 | 15.42% .. 26.11% | ||
| glp-1;nhr-49 | Caenorhabditis elegans | Double mutant | 2 | -34.72% .. 63.43% | ||
| glp-1;nhr-8 | Caenorhabditis elegans | Double mutant | 1 | -40.69% .. 140.59% | [est.] | |
| glp-1;nhr-80 | Caenorhabditis elegans | Double mutant | 8 | -24.24% .. 127.03% | ||
| glp-1;nhr-80;nhr-80 | Caenorhabditis elegans | Triple mutant | 2 | -42.0% .. -170.35% | [est.] | |
| glp-1;pas-1 | Caenorhabditis elegans | Double mutant | 1 | 8.70% | ||
| glp-1;pas-5 | Caenorhabditis elegans | Double mutant | 1 | -28.50% | ||
| glp-1;pas-6 | Caenorhabditis elegans | Double mutant | 1 | -36.23% | ||
| glp-1;pas-7 | Caenorhabditis elegans | Double mutant | 1 | 1.93% | ||
| glp-1;pbs-2 | Caenorhabditis elegans | Double mutant | 1 | -32.37% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group