| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| daf-16;daf-7 | Caenorhabditis elegans | Double mutant | 4 | -28.92% .. -3.70% | ||
| daf-16;daf-9 | Caenorhabditis elegans | Double mutant | 1 | 12.55% | ||
| daf-16;ddl-1 | Caenorhabditis elegans | Double mutant | 2 | -63.46% .. -257.41% | [est.] | |
| daf-16;ddl-2 | Caenorhabditis elegans | Double mutant | 1 | -58.24% .. 69.41% | [est.] | |
| daf-16;ddl-3 | Caenorhabditis elegans | Double mutant | 2 | -64.04% .. -259.76% | [est.] | |
| daf-16;dld-1;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | 68.46% | ||
| daf-16;dpy-20 | Caenorhabditis elegans | Double mutant | 1 | -13.49% | ||
| daf-16;drp-1 | Caenorhabditis elegans | Double mutant | 1 | -37.01% | ||
| daf-16;drr-1 | Caenorhabditis elegans | Double mutant | 1 | -55.63% .. 80.0% | [est.] | |
| daf-16;drr-2 | Caenorhabditis elegans | Double mutant | 1 | -57.66% .. 71.76% | [est.] | |
| daf-16;eak-3 | Caenorhabditis elegans | Double mutant | 1 | -36.24% | ||
| daf-16;eak-7 | Caenorhabditis elegans | Double mutant | 2 | -24.49% .. -20.71% | ||
| daf-16;eat-2 | Caenorhabditis elegans | Double mutant | 5 | -3.94% .. 19.80% | ||
| daf-16;eif-1 | Caenorhabditis elegans | Double mutant | 1 | -7.56% | ||
| daf-16;eif-1;skn-1 | Caenorhabditis elegans | Triple mutant | 1 | -27.41% | ||
| daf-16;elt-6;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -2.73% | ||
| daf-16;epc-1;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -30.15% | ||
| daf-16;ets-4 | Caenorhabditis elegans | Double mutant | 1 | -16.00% | ||
| daf-16;F07A5.1;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -68.74% .. 26.82% | [est.] | |
| daf-16;F08B4.7;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | 9.21% | ||
| daf-16;F09F7.5;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -68.3% .. 28.59% | [est.] | |
| daf-16;F13B6.1;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | 40.92% | ||
| daf-16;F13G3.7 | Caenorhabditis elegans | Double mutant | 1 | -29.17% | ||
| daf-16;F15E6.1;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -69.72% .. 22.82% | [est.] | |
| daf-16;F21H12.1;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -74.04% .. 5.29% | [est.] | |
| daf-16;F26E4.6 | Caenorhabditis elegans | Double mutant | 1 | 15.10% | ||
| daf-16;F26E4.9 | Caenorhabditis elegans | Double mutant | 1 | 31.77% | ||
| daf-16;F28B3.5 | Caenorhabditis elegans | Double mutant | 1 | -38.54% | ||
| daf-16;F42A6.1;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -9.80% | ||
| daf-16;F49C12.9;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -11.51% | ||
| daf-16;F54C4.2;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -63.95% .. 46.24% | [est.] | |
| daf-16;F54H12.1;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -74.51% .. 3.41% | [est.] | |
| daf-16;F55B11.1;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -70.36% .. 20.24% | [est.] | |
| daf-16;F57B10.3 | Caenorhabditis elegans | Double mutant | 1 | -35.94% | ||
| daf-16;faah-1 | Caenorhabditis elegans | Double mutant | 3 | -47.8% .. -193.88% | [est.] | |
| daf-16;fasn-1 | Caenorhabditis elegans | Double mutant | 1 | -40.39% | ||
| daf-16;fem-1;fer-15 | Caenorhabditis elegans | Triple mutant | 3 | -75.93% .. -308.0% | [est.] | |
| daf-16;fer-15 | Caenorhabditis elegans | Double mutant | 1 | -70.71% .. 18.82% | [est.] | |
| daf-16;fer-15;shc-1 | Caenorhabditis elegans | Triple mutant | 1 | -70.42% .. 20.0% | [est.] | |
| daf-16;flr-4 | Caenorhabditis elegans | Double mutant | 2 | 0.46% .. 19.73% | ||
| daf-16;frh-1 | Caenorhabditis elegans | Double mutant | 1 | -46.91% | ||
| daf-16;ftt-1 | Caenorhabditis elegans | Double mutant | 2 | -54.21% .. -25.93% | ||
| daf-16;ftt-2 | Caenorhabditis elegans | Double mutant | 4 | -62.11% .. -6.35% | ||
| daf-16;gcy-35;npr-1 | Caenorhabditis elegans | Triple mutant | 3 | 8.66% .. 12.81% | ||
| daf-16;glp-1 | Caenorhabditis elegans | Double mutant | 39 | -27.18% .. -13.44% | ||
| daf-16;glp-1;nhr-80 | Caenorhabditis elegans | Triple mutant | 4 | -82.6% .. -335.06% | [est.] | |
| daf-16;gpa-1 | Caenorhabditis elegans | Double mutant | 1 | 8.57% | ||
| daf-16;gpa-11 | Caenorhabditis elegans | Double mutant | 1 | -18.86% | ||
| daf-16;gpc-1 | Caenorhabditis elegans | Double mutant | 1 | 1.71% | ||
| daf-16;gpi-1 | Caenorhabditis elegans | Double mutant | 2 | -59.4% .. -240.94% | [est.] |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group