| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| eat-2;mxl-1 | Caenorhabditis elegans | Double mutant | 2 | 46.50% .. 50.00% | ||
| eat-2;mxl-2 | Caenorhabditis elegans | Double mutant | 2 | -13.05% .. -6.00% | ||
| eat-2;nhr-21 | Caenorhabditis elegans | Double mutant | 1 | 26.89% | ||
| eat-2;nhr-4 | Caenorhabditis elegans | Double mutant | 1 | 29.59% | ||
| eat-2;nhr-49 | Caenorhabditis elegans | Double mutant | 3 | -28.20% .. -24.29% | ||
| eat-2;nhr-62 | Caenorhabditis elegans | Double mutant | 4 | -2.29% .. 20.42% | ||
| eat-2;nhr-8 | Caenorhabditis elegans | Double mutant | 2 | 22.59% .. 30.98% | ||
| eat-2;nlp-7 | Caenorhabditis elegans | Double mutant | 2 | 5.13% .. 10.36% | ||
| eat-2;nuo-6 | Caenorhabditis elegans | Double mutant | 2 | 87.04% .. 134.13% | ||
| eat-2;pat-4 | Caenorhabditis elegans | Double mutant | 2 | -45.48% .. -184.47% | [est.] | |
| eat-2;pat-6 | Caenorhabditis elegans | Double mutant | 2 | -38.23% .. -155.06% | [est.] | |
| eat-2;pha-4 | Caenorhabditis elegans | Double mutant | 1 | -24.31% | ||
| eat-2;pqm-1 | Caenorhabditis elegans | Double mutant | 2 | -42.49% .. -172.35% | [est.] | |
| eat-2;prmt-1 | Caenorhabditis elegans | Double mutant | 1 | -39.68% .. 144.71% | [est.] | |
| eat-2;R53.4 | Caenorhabditis elegans | Double mutant | 1 | 61.58% | ||
| eat-2;rab-10 | Caenorhabditis elegans | Double mutant | 2 | -23.72% .. -96.24% | [est.] | |
| eat-2;raga-1 | Caenorhabditis elegans | Double mutant | 3 | -49.54% .. -200.94% | [est.] | |
| eat-2;rha-2 | Caenorhabditis elegans | Double mutant | 1 | -2.55% .. 295.29% | [est.] | |
| eat-2;ril-1 | Caenorhabditis elegans | Double mutant | 1 | 5.57% .. 328.24% | [est.] | |
| eat-2;ril-2 | Caenorhabditis elegans | Double mutant | 1 | 13.69% .. 361.18% | [est.] | |
| eat-2;rps-15 | Caenorhabditis elegans | Double mutant | 2 | -21.98% .. -89.18% | [est.] | |
| eat-2;rps-22 | Caenorhabditis elegans | Double mutant | 1 | -8.06% .. 272.94% | [est.] | |
| eat-2;rrf-3 | Caenorhabditis elegans | Double mutant | 2 | -44.03% .. -178.59% | [est.] | |
| eat-2;rsks-1 | Caenorhabditis elegans | Double mutant | 3 | -37.06% .. -150.35% | [est.] | |
| eat-2;sams-1 | Caenorhabditis elegans | Double mutant | 2 | -22.56% .. -91.53% | [est.] | |
| eat-2;sca-1 | Caenorhabditis elegans | Double mutant | 1 | 2.96% | ||
| eat-2;sir-2.1 | Caenorhabditis elegans | Double mutant | 8 | 2.20% .. 13.58% | ||
| eat-2;skn-1 | Caenorhabditis elegans | Double mutant | 2 | -28.21% .. -19.17% | ||
| eat-2;skr-1 | Caenorhabditis elegans | Double mutant | 2 | -30.97% .. -125.65% | [est.] | |
| eat-2;skr-2 | Caenorhabditis elegans | Double mutant | 2 | -24.88% .. -100.94% | [est.] | |
| eat-2;smk-1 | Caenorhabditis elegans | Double mutant | 1 | -6.40% | ||
| eat-2;sod-2 | Caenorhabditis elegans | Double mutant | 1 | 131.64% | ||
| eat-2;tcer-1 | Caenorhabditis elegans | Double mutant | 5 | -25.46% .. -103.29% | [est.] | |
| eat-2;ubc-18 | Caenorhabditis elegans | Double mutant | 6 | -5.53% .. 6.99% | ||
| eat-2;ubc-18;wwp-1 | Caenorhabditis elegans | Triple mutant | 2 | -46.06% .. -186.82% | [est.] | |
| eat-2;unc-70 | Caenorhabditis elegans | Double mutant | 1 | 21.18% | ||
| eat-2;utx-1 | Caenorhabditis elegans | Double mutant | 2 | 29.28% .. 43.27% | ||
| eat-2;vps-34 | Caenorhabditis elegans | Double mutant | 4 | -35.51% .. | ||
| eat-2;W01B11.3 | Caenorhabditis elegans | Double mutant | 1 | 51.72% | ||
| eat-2;wwp-1 | Caenorhabditis elegans | Double mutant | 9 | -9.57% .. -0.58% | ||
| eat-2;Y39G10AR.8 | Caenorhabditis elegans | Double mutant | 1 | 48.77% | ||
| eat-2;Y47G6A.10 | Caenorhabditis elegans | Double mutant | 1 | 40.89% | ||
| eat-2;Y48G1A.4 | Caenorhabditis elegans | Double mutant | 1 | 34.48% | ||
| eat-2;ZK973.10 | Caenorhabditis elegans | Double mutant | 1 | 46.80% | ||
| egl-1;frh-1 | Caenorhabditis elegans | Double mutant | 1 | 53.37% | ||
| egl-1;isp-1 | Caenorhabditis elegans | Double mutant | 4 | 59.24% .. 69.93% | ||
| egl-1;nuo-6 | Caenorhabditis elegans | Double mutant | 3 | 50.70% .. 57.76% | ||
| egl-3;gcy-35;npr-1 | Caenorhabditis elegans | Triple mutant | 3 | -56.35% .. -228.59% | [est.] | |
| egl-9;gcy-35;npr-1 | Caenorhabditis elegans | Triple mutant | 3 | 32.12% .. 61.28% | ||
| egl-9;hif-1 | Caenorhabditis elegans | Double mutant | 1 | -4.00% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group