| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| dpr-1;isp-1 | Caenorhabditis elegans | Double mutant | 1 | -14.36% .. 247.41% | [est.] | |
| dpy-5;ife-2;let-363;unc-13 | Caenorhabditis elegans | 4-mutant | 1 | 17.03% | ||
| dpy-5;let-363;unc-13 | Caenorhabditis elegans | Triple mutant | 1 | -1.10% | ||
| drl-1;flr-4 | Caenorhabditis elegans | Double mutant | 1 | 57.45% | ||
| drr-1;eat-2 | Caenorhabditis elegans | Double mutant | 2 | -16.47% .. -66.82% | [est.] | |
| drr-1;fem-1;fer-15 | Caenorhabditis elegans | Triple mutant | 1 | -37.35% .. 154.12% | [est.] | |
| drr-2;eat-2 | Caenorhabditis elegans | Double mutant | 3 | -35.61% .. -144.47% | [est.] | |
| drr-2;fem-1;fer-15 | Caenorhabditis elegans | Triple mutant | 2 | -34.16% .. -138.59% | [est.] | |
| E(z);trx | Drosophila melanogaster | Double mutant | 2 | 5.41% .. 13.51% | ||
| E2f1;Rb1 | Mus musculus | Double mutant | 4 | -66.85% .. -190.86% | [est.] | |
| eak-3;eak-7 | Caenorhabditis elegans | Double mutant | 2 | 8.20% .. 42.48% | ||
| eak-6;eak-7 | Caenorhabditis elegans | Double mutant | 2 | 36.97% .. 47.06% | ||
| eak-7;glp-1 | Caenorhabditis elegans | Double mutant | 2 | 120.77% .. 214.56% | ||
| eak-7;hsf-1 | Caenorhabditis elegans | Double mutant | 1 | -24.49% | ||
| eak-7;rle-1 | Caenorhabditis elegans | Double mutant | 2 | -12.08% .. 2.72% | ||
| eak-7;sdf-9 | Caenorhabditis elegans | Double mutant | 2 | 16.67% .. 44.52% | ||
| eak-7;sgk-1 | Caenorhabditis elegans | Double mutant | 2 | -27.89% .. -14.00% | ||
| eak-7;smk-1 | Caenorhabditis elegans | Double mutant | 1 | 9.85% | ||
| eat-2;egl-9 | Caenorhabditis elegans | Double mutant | 1 | 2.74% | ||
| eat-2;elt-3 | Caenorhabditis elegans | Double mutant | 1 | -4.07% | ||
| eat-2;emb-8 | Caenorhabditis elegans | Double mutant | 2 | 40.03% .. 49.28% | ||
| eat-2;F14B4.3 | Caenorhabditis elegans | Double mutant | 1 | 43.35% | ||
| eat-2;F22D6.3 | Caenorhabditis elegans | Double mutant | 1 | 43.84% | ||
| eat-2;F26E4.4 | Caenorhabditis elegans | Double mutant | 1 | 34.98% | ||
| eat-2;F59A3.3 | Caenorhabditis elegans | Double mutant | 1 | 44.83% | ||
| eat-2;F59C6.4 | Caenorhabditis elegans | Double mutant | 1 | 43.84% | ||
| eat-2;F59C6.5 | Caenorhabditis elegans | Double mutant | 1 | 38.92% | ||
| eat-2;fasn-1 | Caenorhabditis elegans | Double mutant | 1 | -6.40% | ||
| eat-2;flr-4;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -24.04% .. 208.12% | [est.] | |
| eat-2;hif-1 | Caenorhabditis elegans | Double mutant | 2 | 20.48% .. 70.89% | ||
| eat-2;ife-2 | Caenorhabditis elegans | Double mutant | 1 | 49.45% | ||
| eat-2;ifg-1 | Caenorhabditis elegans | Double mutant | 4 | 72.41% | ||
| eat-2;iftb-1 | Caenorhabditis elegans | Double mutant | 2 | -22.27% .. -90.35% | [est.] | |
| eat-2;ire-1 | Caenorhabditis elegans | Double mutant | 4 | -14.02% .. 15.59% | ||
| eat-2;isp-1 | Caenorhabditis elegans | Double mutant | 1 | 120.67% | ||
| eat-2;K01C8.6 | Caenorhabditis elegans | Double mutant | 1 | 42.36% | ||
| eat-2;K11B4.1 | Caenorhabditis elegans | Double mutant | 1 | 44.83% | ||
| eat-2;let-363 | Caenorhabditis elegans | Double mutant | 7 | -38.31% .. -155.41% | [est.] | |
| eat-2;let-711 | Caenorhabditis elegans | Double mutant | 1 | 11.33% | ||
| eat-2;lin-15b;nhr-21;nre-1 | Caenorhabditis elegans | 4-mutant | 2 | -51.68% .. -209.65% | [est.] | |
| eat-2;lin-15b;nhr-35;nre-1 | Caenorhabditis elegans | 4-mutant | 2 | -56.55% .. -229.41% | [est.] | |
| eat-2;lin-15b;nhr-49;nre-1 | Caenorhabditis elegans | 4-mutant | 1 | -57.08% .. 74.12% | [est.] | |
| eat-2;lin-15b;nhr-4;nre-1 | Caenorhabditis elegans | 4-mutant | 1 | -42.23% .. 134.35% | [est.] | |
| eat-2;lin-15b;nhr-62;nre-1 | Caenorhabditis elegans | 4-mutant | 4 | -58.38% .. -236.82% | [est.] | |
| eat-2;lin-15b;nre-1 | Caenorhabditis elegans | Triple mutant | 5 | -56.58% .. -229.53% | [est.] | |
| eat-2;lin-15b;nre-1;pha-4 | Caenorhabditis elegans | 4-mutant | 1 | -56.26% .. 77.41% | [est.] | |
| eat-2;mdl-1 | Caenorhabditis elegans | Double mutant | 1 | 60.00% | ||
| eat-2;mdt-15 | Caenorhabditis elegans | Double mutant | 1 | -16.75% | ||
| eat-2;mekk-3 | Caenorhabditis elegans | Double mutant | 6 | 13.88% .. 72.54% | ||
| eat-2;mml-1 | Caenorhabditis elegans | Double mutant | 1 | 8.50% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group