| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| Atm;Rad54 | Mus musculus | Double mutant | 1 | -86.82% .. -62.37% | [est.] | |
| Atm;Rad54B | Mus musculus | Double mutant | 1 | -84.18% .. -54.84% | [est.] | |
| Atm;Sirt6 | Mus musculus | Double mutant | 2 | -87.1% .. -248.66% | [est.] | |
| Atm;Terc | Mus musculus | Double mutant | 2 | -37.70% | ||
| atp-3;cep-1 | Caenorhabditis elegans | Double mutant | 2 | -27.65% .. 61.64% | ||
| atp-3;daf-16 | Caenorhabditis elegans | Double mutant | 1 | -57.95% .. 70.59% | [est.] | |
| atp-3;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 18.33% .. 380.0% | [est.] | |
| atp-3;egl-1 | Caenorhabditis elegans | Double mutant | 1 | -52.76% | ||
| atp-3;fem-1;fer-15 | Caenorhabditis elegans | Triple mutant | 1 | -26.91% .. 196.47% | [est.] | |
| atp-3;kin-29 | Caenorhabditis elegans | Double mutant | 1 | 18.60% | ||
| atp-3;mml-1 | Caenorhabditis elegans | Double mutant | 1 | 25.58% | ||
| atp-3;par-4 | Caenorhabditis elegans | Double mutant | 1 | 48.84% | ||
| atp-3;sad-1 | Caenorhabditis elegans | Double mutant | 1 | 33.14% | ||
| atp-4;daf-16 | Caenorhabditis elegans | Double mutant | 1 | -37.94% .. 151.76% | [est.] | |
| atp-4;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 40.08% .. 468.24% | [est.] | |
| atp-4;fem-1;fer-15 | Caenorhabditis elegans | Triple mutant | 1 | -4.58% .. 287.06% | [est.] | |
| atp-5;daf-16 | Caenorhabditis elegans | Double mutant | 1 | -48.96% .. 107.06% | [est.] | |
| atp-5;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 71.98% .. 597.65% | [est.] | |
| atp-5;fem-1;fer-15 | Caenorhabditis elegans | Triple mutant | 1 | -24.3% .. 207.06% | [est.] | |
| ATPCL;chm | Drosophila melanogaster | Double mutant | 1 | -28.0% .. 83.67% | [est.] | |
| B0261.4;daf-16 | Caenorhabditis elegans | Double mutant | 1 | -14.06% | ||
| B0303.9;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -34.69% | ||
| B0303.9;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 80.27% | ||
| B0334.8;daf-16;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -68.01% .. 29.76% | [est.] | |
| B0334.8;rrf-3;sir-2.1 | Caenorhabditis elegans | Triple mutant | 1 | -46.55% .. 116.82% | [est.] | |
| B0395.2;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -41.50% | ||
| B0395.2;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 85.03% | ||
| B0464.7;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -31.97% | ||
| B0464.7;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 72.79% | ||
| B0491.5;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -35.96% | ||
| B0491.5;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 137.93% | ||
| B0491.5;eat-2 | Caenorhabditis elegans | Double mutant | 1 | 2.46% | ||
| B0511.8;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -31.53% | ||
| B0511.8;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 139.90% | ||
| B0511.8;eat-2 | Caenorhabditis elegans | Double mutant | 1 | 41.38% | ||
| B0546.3;daf-16;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -10.23% | ||
| bax;Ku70 | Mus musculus | Double mutant | 6 | -71.82% .. -60.00% | ||
| BE10.2;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -34.01% | ||
| BE10.2;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 3.40% | ||
| bec-1;ced-3 | Caenorhabditis elegans | Double mutant | 1 | -39.39% .. 145.88% | [est.] | |
| bec-1;clk-1 | Caenorhabditis elegans | Double mutant | 4 | -34.74% .. -140.94% | [est.] | |
| bec-1;daf-15;unc-24 | Caenorhabditis elegans | Triple mutant | 6 | -18.22% .. -1.51% | ||
| bec-1;daf-16 | Caenorhabditis elegans | Double mutant | 1 | -60.56% .. 60.0% | [est.] | |
| bec-1;daf-16;sir-2.1 | Caenorhabditis elegans | Triple mutant | 1 | -62.3% .. 52.94% | [est.] | |
| bec-1;daf-2 | Caenorhabditis elegans | Double mutant | 3 | 89.50% | ||
| bec-1;daf-2;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 6 | 21.21% .. 45.14% | ||
| bec-1;eat-2 | Caenorhabditis elegans | Double mutant | 7 | -28.43% .. 45.71% | ||
| bec-1;eat-2;rrf-3 | Caenorhabditis elegans | Triple mutant | 3 | -19.29% | ||
| bec-1;fem-1;fer-15 | Caenorhabditis elegans | Triple mutant | 1 | 24.57% | ||
| bec-1;frh-1 | Caenorhabditis elegans | Double mutant | 2 | -54.35% .. -9.24% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group