| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| alpha-Man-Ia;Edem1 | Drosophila melanogaster | Double mutant | 3 | 31.82% .. 40.91% | ||
| amt-2;daf-16;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -6.73% | ||
| Apc;Egr1 | Mus musculus | Double mutant | 2 | -83.24% .. -237.63% | [est.] | |
| Apc;Egr1;Trp53 | Mus musculus | Triple mutant | 1 | -83.24% .. -52.15% | [est.] | |
| Apc;Ku80 | Mus musculus | Double mutant | 2 | -73.60% .. -66.40% | ||
| Apc;Trp53 | Mus musculus | Double mutant | 1 | -86.44% .. -61.29% | [est.] | |
| arx-4;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -66.67% | ||
| arx-4;daf-2 | Caenorhabditis elegans | Double mutant | 1 | -6.12% | ||
| asb-2;daf-16 | Caenorhabditis elegans | Double mutant | 1 | -38.52% .. 149.41% | [est.] | |
| asb-2;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 69.95% .. 589.41% | [est.] | |
| asb-2;fem-1;fer-15 | Caenorhabditis elegans | Triple mutant | 1 | -44.61% .. 124.71% | [est.] | |
| ash-2;rrf-1 | Caenorhabditis elegans | Double mutant | 3 | 28.22% .. 39.73% | ||
| asm-1;asm-3;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | 30.46% | ||
| asm-1;daf-18;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -71.0% .. 17.65% | [est.] | |
| asm-2;asm-3;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | 28.16% | ||
| asm-2;daf-18;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -69.84% .. 22.35% | [est.] | |
| asm-3;daf-16 | Caenorhabditis elegans | Double mutant | 1 | -7.43% | ||
| asm-3;daf-16;rrf-3 | Caenorhabditis elegans | Triple mutant | 2 | -26.44% .. -11.76% | ||
| asm-3;daf-18;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -70.71% .. 18.82% | [est.] | |
| asm-3;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 147.53% | ||
| asm-3;pdk-1 | Caenorhabditis elegans | Double mutant | 1 | 50.69% | ||
| asm-3;rrf-3 | Caenorhabditis elegans | Double mutant | 1 | 15.52% | ||
| asp-3;daf-2;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 1 | -24.59% .. 205.88% | [est.] | |
| asp-3;fem-1;fer-15 | Caenorhabditis elegans | Triple mutant | 1 | -56.5% .. 76.47% | [est.] | |
| atf-6;daf-2 | Caenorhabditis elegans | Double mutant | 3 | 47.06% .. 115.66% | ||
| atfs-1;cco-1 | Caenorhabditis elegans | Double mutant | 1 | 57.15% | ||
| atfs-1;cyc-2.1 | Caenorhabditis elegans | Double mutant | 2 | 1.50% .. 4.76% | ||
| atfs-1;daf-2;rsks-1 | Caenorhabditis elegans | Triple mutant | 3 | 99.49% .. 123.86% | ||
| atg-10;daf-2 | Caenorhabditis elegans | Double mutant | 2 | 79.91% .. 86.45% | ||
| atg-16.2;daf-2 | Caenorhabditis elegans | Double mutant | 2 | 88.13% .. 104.21% | ||
| atg-18;daf-2 | Caenorhabditis elegans | Double mutant | 2 | 11.21% .. 77.63% | ||
| atg-18;glp-1 | Caenorhabditis elegans | Double mutant | 3 | -21.86% .. -8.06% | ||
| atg-18;mes-1 | Caenorhabditis elegans | Double mutant | 1 | -26.51% | ||
| atg-18;rsks-1 | Caenorhabditis elegans | Double mutant | 4 | -4.62% .. 3.90% | ||
| atg-3;daf-2 | Caenorhabditis elegans | Double mutant | 2 | 87.67% .. 105.14% | ||
| atg-4.1;daf-2 | Caenorhabditis elegans | Double mutant | 2 | 69.41% .. 74.30% | ||
| atg-4.2;daf-2 | Caenorhabditis elegans | Double mutant | 2 | 73.36% .. 81.28% | ||
| atg-5;daf-2 | Caenorhabditis elegans | Double mutant | 2 | 84.02% .. 119.63% | ||
| atg-7;daf-2 | Caenorhabditis elegans | Double mutant | 2 | 68.95% .. 95.79% | ||
| atg-9;ced-3 | Caenorhabditis elegans | Double mutant | 1 | -25.46% .. 202.35% | [est.] | |
| atg-9;clk-1 | Caenorhabditis elegans | Double mutant | 1 | -20.82% .. 221.18% | [est.] | |
| atg-9;daf-16 | Caenorhabditis elegans | Double mutant | 1 | -60.56% .. 60.0% | [est.] | |
| atg-9;daf-16;sir-2.1 | Caenorhabditis elegans | Triple mutant | 1 | -61.14% .. 57.65% | [est.] | |
| atg-9;daf-2 | Caenorhabditis elegans | Double mutant | 2 | 110.28% .. 113.24% | ||
| atg-9;mev-1 | Caenorhabditis elegans | Double mutant | 1 | -51.57% .. 96.47% | [est.] | |
| atg-9;rsks-1 | Caenorhabditis elegans | Double mutant | 1 | -36.19% .. 158.82% | [est.] | |
| atg-9;sir-2.1 | Caenorhabditis elegans | Double mutant | 2 | -19.37% .. -78.59% | [est.] | |
| atk-1;oga-1 | Caenorhabditis elegans | Double mutant | 1 | 24.53% | ||
| atm-1;atp-3 | Caenorhabditis elegans | Double mutant | 2 | -75.00% .. -68.71% | ||
| atm-1;frh-1 | Caenorhabditis elegans | Double mutant | 2 | 54.02% .. 60.74% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group