| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| daf-2;H27M09.1 | Double mutant | 1 | 78.23% | ||
| daf-2;hcf-1 | Double mutant | 3 | 108.28% .. 174.83% | ||
| daf-2;hif-1 | Double mutant | 2 | 70.00% .. 157.35% | ||
| daf-2;his-71 | Double mutant | 1 | 83.67% | ||
| daf-2;hpk-1 | Double mutant | 1 | 55.10% | ||
| daf-2;hsf-1 | Double mutant | 6 | -61.93% .. 45.91% | ||
| daf-2;hsf-1;rsks-1 | Triple mutant | 5 | -49.24% .. -32.80% | ||
| daf-2;ife-2 | Double mutant | 1 | 156.04% | ||
| daf-2;ifg-1 | Double mutant | 4 | 120.69% | ||
| daf-2;ifta-2 | Double mutant | 1 | 47.81% | ||
| daf-2;iftb-1 | Double mutant | 3 | -21.4% .. -86.82% | [est.] | |
| daf-2;ins-18 | Double mutant | 2 | 75.00% .. 216.00% | ||
| daf-2;ire-1 | Double mutant | 15 | -6.44% .. 82.80% | ||
| daf-2;ire-1;xbp-1 | Triple mutant | 2 | -38.81% .. -157.41% | [est.] | |
| daf-2;isp-1 | Double mutant | 3 | 102.46% .. 115.82% | ||
| daf-2;isw-1 | Double mutant | 3 | 60.81% .. 108.12% | ||
| daf-2;jnk-1 | Double mutant | 1 | 202.84% | ||
| daf-2;K01C8.6 | Double mutant | 1 | 129.56% | ||
| daf-2;K04C2.5 | Double mutant | 1 | -17.34% .. 235.29% | [est.] | |
| daf-2;K10H10.4 | Double mutant | 1 | -33.58% .. 169.41% | [est.] | |
| daf-2;K11B4.1 | Double mutant | 1 | 115.76% | ||
| daf-2;K11D12.9 | Double mutant | 1 | 85.03% | ||
| daf-2;kri-1 | Double mutant | 3 | -12.12% .. -49.18% | [est.] | |
| daf-2;kri-1;rrf-3 | Triple mutant | 2 | -27.2% .. -110.35% | [est.] | |
| daf-2;kri-1;rsks-1 | Triple mutant | 2 | 16.3% .. 66.12% | [est.] | |
| daf-2;let-363 | Double mutant | 3 | -13.57% .. -55.06% | [est.] | |
| daf-2;let-60 | Double mutant | 6 | -21.59% .. 55.68% | ||
| daf-2;let-653 | Double mutant | 1 | 74.83% | ||
| daf-2;let-711 | Double mutant | 1 | 70.94% | ||
| daf-2;lgg-1 | Double mutant | 2 | 78.97% .. 79.45% | ||
| daf-2;lgg-2 | Double mutant | 2 | 91.59% .. 96.80% | ||
| daf-2;lgg-3 | Double mutant | 2 | 82.65% .. 117.76% | ||
| daf-2;lin-14 | Double mutant | 2 | 43.98% .. 158.43% | ||
| daf-2;lin-23 | Double mutant | 29 | -17.18% .. 17.39% | ||
| daf-2;lin-4 | Double mutant | 1 | -13.75% | ||
| daf-2;lipl-4 | Double mutant | 1 | 54.82% | ||
| daf-2;lmn-1 | Double mutant | 1 | 56.46% | ||
| daf-2;lsm-4 | Double mutant | 1 | 95.92% | ||
| daf-2;lsm-7 | Double mutant | 1 | 88.44% | ||
| daf-2;M03F4.7 | Double mutant | 1 | 104.08% | ||
| daf-2;M05B5.2 | Double mutant | 1 | 38.78% | ||
| daf-2;M57.2 | Double mutant | 1 | 55.78% | ||
| daf-2;mag-1 | Double mutant | 1 | 68.71% | ||
| daf-2;maoc-1 | Double mutant | 1 | -15.31% .. 243.53% | [est.] | |
| daf-2;mcm-2 | Double mutant | 1 | 72.11% | ||
| daf-2;mdh-1 | Double mutant | 1 | 118.37% | ||
| daf-2;mdt-15 | Double mutant | 1 | 47.78% | ||
| daf-2;med-1 | Double mutant | 3 | 52.05% .. 163.16% | ||
| daf-2;mekk-3 | Double mutant | 6 | 108.59% .. 267.93% | ||
| daf-2;mep-1 | Double mutant | 1 | 57.82% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
