| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| gld-1;rsks-1 | Double mutant | 2 | -7.14% .. -3.33% | ||
| glp-1;gpi-1 | Double mutant | 2 | -28.36% .. -115.06% | [est.] | |
| glp-1;hcf-1 | Double mutant | 1 | 57.35% | ||
| glp-1;hif-1 | Double mutant | 1 | 43.79% | ||
| glp-1;hlh-30 | Double mutant | 4 | -8.33% .. 22.92% | ||
| glp-1;ifg-1 | Double mutant | 1 | 57.50% | ||
| glp-1;kri-1 | Double mutant | 2 | -50.7% .. -205.65% | [est.] | |
| glp-1;lgg-1 | Double mutant | 3 | -35.94% .. 9.50% | ||
| glp-1;lipl-4 | Double mutant | 4 | 10.70% .. 11.68% | ||
| glp-1;lipl-4;vps-34 | Triple mutant | 2 | -54.47% .. -220.94% | [est.] | |
| glp-1;lmp-1 | Double mutant | 4 | -11.48% .. 15.82% | ||
| glp-1;maoc-1 | Double mutant | 2 | -24.01% .. -97.41% | [est.] | |
| glp-1;mekk-3 | Double mutant | 2 | 15.42% .. 26.11% | ||
| glp-1;nhr-49 | Double mutant | 2 | -34.72% .. 63.43% | ||
| glp-1;nhr-8 | Double mutant | 1 | -40.69% .. 140.59% | [est.] | |
| glp-1;nhr-80 | Double mutant | 8 | -24.24% .. 127.03% | ||
| glp-1;nhr-80;nhr-80 | Triple mutant | 2 | -42.0% .. -170.35% | [est.] | |
| glp-1;pas-1 | Double mutant | 1 | 8.70% | ||
| glp-1;pas-5 | Double mutant | 1 | -28.50% | ||
| glp-1;pas-6 | Double mutant | 1 | -36.23% | ||
| glp-1;pas-7 | Double mutant | 1 | 1.93% | ||
| glp-1;pbs-2 | Double mutant | 1 | -32.37% | ||
| glp-1;pbs-3 | Double mutant | 1 | -39.13% | ||
| glp-1;pbs-4 | Double mutant | 1 | -25.60% | ||
| glp-1;pbs-5 | Double mutant | 1 | -31.88% | ||
| glp-1;pbs-6 | Double mutant | 1 | -24.64% | ||
| glp-1;pbs-7 | Double mutant | 1 | -28.02% | ||
| glp-1;pha-4 | Double mutant | 3 | -12.38% .. -9.57% | ||
| glp-1;raga-1 | Double mutant | 4 | 31.75% .. 54.18% | ||
| glp-1;rpn-1 | Double mutant | 1 | -23.67% | ||
| glp-1;rpn-10 | Double mutant | 1 | -2.42% | ||
| glp-1;rpn-11 | Double mutant | 1 | -33.82% | ||
| glp-1;rpn-12 | Double mutant | 1 | 1.45% | ||
| glp-1;rpn-2 | Double mutant | 1 | -27.05% | ||
| glp-1;rpn-3 | Double mutant | 1 | -23.67% | ||
| glp-1;rpn-5 | Double mutant | 1 | 14.98% | ||
| glp-1;rpn-6 | Double mutant | 1 | -32.85% | ||
| glp-1;rpn-7 | Double mutant | 1 | -27.54% | ||
| glp-1;rpn-8 | Double mutant | 1 | -28.50% | ||
| glp-1;rpn-9 | Double mutant | 1 | -19.32% | ||
| glp-1;rpt-1 | Double mutant | 1 | -27.54% | ||
| glp-1;rpt-2 | Double mutant | 1 | 1.45% | ||
| glp-1;rpt-3 | Double mutant | 1 | -31.40% | ||
| glp-1;rpt-4 | Double mutant | 1 | -38.16% | ||
| glp-1;rpt-5 | Double mutant | 1 | -27.54% | ||
| glp-1;rpt-6 | Double mutant | 1 | -31.40% | ||
| glp-1;rsks-1 | Double mutant | 2 | -22.31% .. -8.59% | ||
| glp-1;sinh-1 | Double mutant | 2 | -43.45% .. -176.24% | [est.] | |
| glp-1;skr-1 | Double mutant | 3 | -37.35% .. -151.53% | [est.] | |
| glp-1;skr-11 | Double mutant | 2 | -23.43% .. -95.06% | [est.] |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
