| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| glp-1;skr-12 | Double mutant | 2 | -26.91% .. -109.18% | [est.] | |
| glp-1;skr-13 | Double mutant | 2 | -27.2% .. -110.35% | [est.] | |
| glp-1;skr-15 | Double mutant | 2 | -24.88% .. -100.94% | [est.] | |
| glp-1;skr-19 | Double mutant | 2 | -21.4% .. -86.82% | [est.] | |
| glp-1;skr-2 | Double mutant | 2 | -35.9% .. -145.65% | [est.] | |
| glp-1;skr-20 | Double mutant | 2 | -33.58% .. -136.24% | [est.] | |
| glp-1;skr-3 | Double mutant | 2 | -26.04% .. -105.65% | [est.] | |
| glp-1;skr-5 | Double mutant | 1 | -21.4% .. 218.82% | [est.] | |
| glp-1;skr-7 | Double mutant | 2 | -23.43% .. -95.06% | [est.] | |
| glp-1;skr-8 | Double mutant | 2 | -28.94% .. -117.41% | [est.] | |
| glp-1;smk-1 | Double mutant | 1 | -66.07% .. 37.65% | [est.] | |
| glp-1;sod-2 | Double mutant | 1 | 116.95% | ||
| glp-1;tcer-1 | Double mutant | 29 | -33.17% .. 79.46% | ||
| glp-1;tcer-1;tcer-1 | Triple mutant | 5 | 39.46% .. 74.19% | ||
| glp-1;tor | Double mutant | 4 | -3.65% .. 29.19% | ||
| glp-1;ttr-1 | Double mutant | 2 | -46.93% .. -190.35% | [est.] | |
| glp-1;unc-51 | Double mutant | 3 | -12.57% .. 5.39% | ||
| glp-1;utx-1 | Double mutant | 5 | 12.44% .. 45.21% | ||
| glp-1;vha-16 | Double mutant | 4 | -21.14% .. | ||
| glp-1;vps-34 | Double mutant | 5 | -19.27% .. -0.56% | ||
| glp-4;ife-2 | Double mutant | 1 | 23.28% | ||
| glp-4;mnk-1 | Double mutant | 1 | -6.03% | ||
| glp-4;mpk-1 | Double mutant | 1 | -7.00% | ||
| gpa-11;gpc-1 | Double mutant | 2 | 7.19% .. 25.15% | ||
| gpa-11;odr-3 | Double mutant | 6 | -11.38% .. 98.29% | ||
| gpa-1;gpa-11 | Double mutant | 2 | 1.20% .. 28.74% | ||
| gpa-1;gpc-1 | Double mutant | 1 | 21.56% | ||
| gpa-1;odr-3 | Double mutant | 1 | 27.54% | ||
| gpc-1;odr-3 | Double mutant | 1 | 21.56% | ||
| gpdh-1;gpdh-2 | Double mutant | 1 | 21.89% | ||
| hcf-1;par-5 | Double mutant | 1 | -41.94% | ||
| hcf-1;par-5gs | Double mutant | 1 | 34.41% | ||
| hcf-1;sgk-1 | Double mutant | 3 | -40.11% .. 17.65% | ||
| hcf-1;sir-2.1 | Double mutant | 27 | 3.33% .. 47.22% | ||
| hif-1;ire-1 | Double mutant | 1 | -36.11% | ||
| hif-1;isp-1 | Double mutant | 4 | 10.42% .. 16.46% | ||
| hif-1;npr-1 | Double mutant | 3 | -22.59% .. -16.75% | ||
| hif-1;osm-5 | Double mutant | 1 | 33.33% | ||
| hif-1;pha-4 | Double mutant | 1 | 17.86% | ||
| hif-1;rsks-1 | Double mutant | 1 | 21.43% | ||
| hif-1;skn-1 | Double mutant | 1 | -26.00% | ||
| hif-1;tpk-1 | Double mutant | 1 | -15.14% .. 244.24% | [est.] | |
| hif-1;vhl-1 | Double mutant | 18 | -3.51% .. 28.20% | ||
| hif-1;xbp-1 | Double mutant | 1 | -4.03% | ||
| him-5;ins-1 | Double mutant | 1 | -69.26% .. 24.71% | [est.] | |
| hlh-30;mxl-3 | Double mutant | 1 | 5.00% | ||
| hlh-30;tor | Double mutant | 3 | -10.65% .. 4.09% | ||
| hsb-1;hsf-1 | Double mutant | 2 | -42.55% .. -39.46% | ||
| hsf-1;mekk-3 | Double mutant | 2 | 61.40% .. 94.68% | ||
| hsf-1;nmur-1 | Double mutant | 1 | -25.45% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
