| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| fem-1;fer-15;nuo-2 | Caenorhabditis elegans | Triple mutant | 1 | -44.9% .. 123.53% | [est.] | |
| fem-1;fer-15;nuo-3 | Caenorhabditis elegans | Triple mutant | 1 | -18.5% .. 230.59% | [est.] | |
| fem-1;fer-15;nuo-4 | Caenorhabditis elegans | Triple mutant | 1 | -25.75% .. 201.18% | [est.] | |
| fem-1;fer-15;nuo-5 | Caenorhabditis elegans | Triple mutant | 2 | -32.42% .. -131.53% | [est.] | |
| fem-1;fer-15;pat-4 | Caenorhabditis elegans | Triple mutant | 2 | -27.2% .. -110.35% | [est.] | |
| fem-1;fer-15;pat-6 | Caenorhabditis elegans | Triple mutant | 2 | -42.58% .. -172.71% | [est.] | |
| fem-1;fer-15;pep-2 | Caenorhabditis elegans | Triple mutant | 1 | -69.26% .. 24.71% | [est.] | |
| fem-1;fer-15;pes-2 | Caenorhabditis elegans | Triple mutant | 1 | -57.08% .. 74.12% | [est.] | |
| fem-1;fer-15;rab-10 | Caenorhabditis elegans | Triple mutant | 1 | -26.62% .. 197.65% | [est.] | |
| fem-1;fer-15;rha-2 | Caenorhabditis elegans | Triple mutant | 2 | -32.71% .. -132.71% | [est.] | |
| fem-1;fer-15;ril-1 | Caenorhabditis elegans | Triple mutant | 2 | -17.05% .. -69.18% | [est.] | |
| fem-1;fer-15;ril-2 | Caenorhabditis elegans | Triple mutant | 2 | -27.49% .. -111.53% | [est.] | |
| fem-1;fer-15;ril-3 | Caenorhabditis elegans | Triple mutant | 1 | -24.59% .. 205.88% | [est.] | |
| fem-1;fer-15;rpl-19 | Caenorhabditis elegans | Triple mutant | 1 | -48.67% .. 108.24% | [est.] | |
| fem-1;fer-15;rpl-30 | Caenorhabditis elegans | Triple mutant | 1 | -26.91% .. 196.47% | [est.] | |
| fem-1;fer-15;rpl-4 | Caenorhabditis elegans | Triple mutant | 1 | -47.22% .. 114.12% | [est.] | |
| fem-1;fer-15;rpl-9 | Caenorhabditis elegans | Triple mutant | 1 | -32.42% .. 174.12% | [est.] | |
| fem-1;fer-15;rps-10 | Caenorhabditis elegans | Triple mutant | 1 | -46.06% .. 118.82% | [est.] | |
| fem-1;fer-15;rps-11 | Caenorhabditis elegans | Triple mutant | 1 | -18.79% .. 229.41% | [est.] | |
| fem-1;fer-15;rps-15 | Caenorhabditis elegans | Triple mutant | 1 | -11.25% .. 260.0% | [est.] | |
| fem-1;fer-15;rps-22 | Caenorhabditis elegans | Triple mutant | 2 | -43.74% .. -177.41% | [est.] | |
| fem-1;fer-15;rps-26 | Caenorhabditis elegans | Triple mutant | 1 | -44.32% .. 125.88% | [est.] | |
| fem-1;fer-15;rps-6 | Caenorhabditis elegans | Triple mutant | 1 | -21.4% .. 218.82% | [est.] | |
| fem-1;fer-15;rsks-1 | Caenorhabditis elegans | Triple mutant | 2 | -28.07% .. -113.88% | [est.] | |
| fem-1;fer-15;sams-1 | Caenorhabditis elegans | Triple mutant | 1 | -28.94% .. 188.24% | [est.] | |
| fem-1;fer-15;sinh-1 | Caenorhabditis elegans | Triple mutant | 1 | -47.8% .. 111.76% | [est.] | |
| fem-1;fer-15;ttr-1 | Caenorhabditis elegans | Triple mutant | 2 | -30.68% .. -124.47% | [est.] | |
| fem-1;fer-15;vit-2 | Caenorhabditis elegans | Triple mutant | 1 | -55.34% .. 81.18% | [est.] | |
| fem-1;fer-15;vit-4 | Caenorhabditis elegans | Triple mutant | 1 | -63.75% .. 47.06% | [est.] | |
| fem-1;fer-15;vit-5 | Caenorhabditis elegans | Triple mutant | 1 | -53.89% .. 87.06% | [est.] | |
| fem-1;fer-15;vps-34 | Caenorhabditis elegans | Triple mutant | 4 | -8.30% .. 2.18% | ||
| fem-1;fer-15;xbp-1 | Caenorhabditis elegans | Triple mutant | 1 | -60.27% .. 61.18% | [est.] | |
| fem-1;fer-15;zig-6 | Caenorhabditis elegans | Triple mutant | 2 | -49.25% .. -199.76% | [est.] | |
| fer-15;shc-1 | Caenorhabditis elegans | Double mutant | 2 | -69.55% .. -282.12% | [est.] | |
| flr-4;gld-1 | Caenorhabditis elegans | Double mutant | 1 | 17.31% | ||
| flr-4;glp-1 | Caenorhabditis elegans | Double mutant | 1 | 33.02% | ||
| flr-4;glp-4 | Caenorhabditis elegans | Double mutant | 1 | 14.88% | ||
| flr-4;nhr-8 | Caenorhabditis elegans | Double mutant | 2 | -24.14% .. 9.12% | ||
| flr-4;nsy-1 | Caenorhabditis elegans | Double mutant | 2 | -13.03% .. 6.72% | ||
| flr-4;pha-4;smg-1 | Caenorhabditis elegans | Triple mutant | 1 | -27.87% .. 192.59% | [est.] | |
| flr-4;pmk-1 | Caenorhabditis elegans | Double mutant | 1 | 5.39% | ||
| flr-4;pmk-3 | Caenorhabditis elegans | Double mutant | 1 | 51.94% | ||
| flr-4;rde-1 | Caenorhabditis elegans | Double mutant | 1 | -55.25% .. 81.53% | [est.] | |
| flr-4;rrf-3 | Caenorhabditis elegans | Double mutant | 1 | -15.95% .. 240.94% | [est.] | |
| flr-4;sek-1 | Caenorhabditis elegans | Double mutant | 3 | -3.53% .. 6.83% | ||
| flr-4;sid-1 | Caenorhabditis elegans | Double mutant | 1 | -50.2% .. 102.0% | [est.] | |
| flr-4;skn-1 | Caenorhabditis elegans | Double mutant | 1 | 12.19% | ||
| flr-4;smg-1 | Caenorhabditis elegans | Double mutant | 2 | 5.92% .. 329.65% | [est.] | |
| flr-4;tir-1 | Caenorhabditis elegans | Double mutant | 1 | 13.72% | ||
| flr-4;unc-43 | Caenorhabditis elegans | Double mutant | 1 | -8.86% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group