| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| daf-16;K08E3.5;rrf-3 | Triple mutant | 1 | -71.93% .. 13.88% | [est.] | |
| daf-16;K10B4.3;rrf-3 | Triple mutant | 1 | -71.55% .. 15.41% | [est.] | |
| daf-16;K11D12.1;rrf-3 | Triple mutant | 1 | -69.75% .. 22.71% | [est.] | |
| daf-16;K12H4.5;rrf-3 | Triple mutant | 1 | 7.89% | ||
| daf-16;let-363 | Double mutant | 4 | -55.34% .. -224.47% | [est.] | |
| daf-16;let-711 | Double mutant | 1 | -40.39% | ||
| daf-16;lin-14 | Double mutant | 2 | -22.69% .. -5.62% | ||
| daf-16;lin-4 | Double mutant | 1 | -61.88% | ||
| daf-16;maoc-1 | Double mutant | 2 | -59.4% .. -240.94% | [est.] | |
| daf-16;mars-1;rrf-3 | Triple mutant | 1 | 16.11% | ||
| daf-16;mdt-15 | Double mutant | 1 | -40.39% | ||
| daf-16;mekk-3 | Double mutant | 2 | 28.17% .. 47.07% | ||
| daf-16;mpk-1 | Double mutant | 1 | -66.94% .. 34.12% | [est.] | |
| daf-16;mrlp-1;rrf-3 | Triple mutant | 1 | 1.96% | ||
| daf-16;mxl-1 | Double mutant | 2 | 1.48% .. 2.96% | ||
| daf-16;mxl-2 | Double mutant | 2 | 0.74% .. 5.19% | ||
| daf-16;nhr-49 | Double mutant | 2 | -41.87% .. -5.95% | ||
| daf-16;nmur-1 | Double mutant | 1 | 0.85% | ||
| daf-16;npr-1 | Double mutant | 3 | 2.59% .. 15.74% | ||
| daf-16;nuo-2 | Double mutant | 1 | -60.27% .. 61.18% | [est.] | |
| daf-16;nuo-3 | Double mutant | 1 | -47.8% .. 111.76% | [est.] | |
| daf-16;nuo-4 | Double mutant | 1 | -40.55% .. 141.18% | [est.] | |
| daf-16;nuo-5 | Double mutant | 1 | -56.79% .. 75.29% | [est.] | |
| daf-16;ocr-2 | Double mutant | 3 | -48.96% .. -22.92% | ||
| daf-16;odr-3 | Double mutant | 1 | -22.29% | ||
| daf-16;oga-1 | Double mutant | 1 | -6.92% | ||
| daf-16;ogdh-1;rrf-3 | Triple mutant | 1 | 66.41% | ||
| daf-16;ogt-1 | Double mutant | 1 | -19.50% | ||
| daf-16;osm-3 | Double mutant | 1 | 2.13% | ||
| daf-16;osm-5 | Double mutant | 1 | -0.53% | ||
| daf-16;osm-6 | Double mutant | 1 | -60.19% | ||
| daf-16;par-5 | Double mutant | 2 | -30.00% .. -28.57% | ||
| daf-16;pat-4 | Double mutant | 1 | -55.05% .. 82.35% | [est.] | |
| daf-16;pat-4;rrf-3 | Triple mutant | 1 | 5.92% | ||
| daf-16;pat-6 | Double mutant | 1 | -57.66% .. 71.76% | [est.] | |
| daf-16;pdk-1 | Double mutant | 2 | -20.11% .. -11.76% | ||
| daf-16;pep-2 | Double mutant | 2 | -32.73% .. -31.62% | ||
| daf-16;pkc-2 | Double mutant | 4 | -26.26% .. -13.57% | ||
| daf-16;pmq-1 | Double mutant | 1 | -22.18% | ||
| daf-16;pod-1;rrf-3 | Triple mutant | 1 | -40.81% | ||
| daf-16;prmt-1 | Double mutant | 6 | -68.1% .. -276.24% | [est.] | |
| daf-16;qars-1;rrf-3 | Triple mutant | 1 | -0.43% | ||
| daf-16;R05A10.5;rrf-3 | Triple mutant | 1 | -69.34% .. 24.35% | [est.] | |
| daf-16;R08E3.3;rrf-3 | Triple mutant | 1 | -72.22% .. 12.71% | [est.] | |
| daf-16;R10H10.7;rrf-3 | Triple mutant | 1 | -19.86% | ||
| daf-16;rab-10 | Double mutant | 1 | -58.24% .. 69.41% | [est.] | |
| daf-16;raga-1 | Double mutant | 6 | -32.32% .. -14.43% | ||
| daf-16;raga-1;skn-1 | Triple mutant | 3 | -19.87% .. -14.98% | ||
| daf-16;ragc-1 | Double mutant | 4 | -16.89% .. -5.61% | ||
| daf-16;ral-1;rrf-3 | Triple mutant | 1 | -14.44% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
