| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| daf-2;vps-16 | Double mutant | 1 | 61.90% | ||
| daf-2;vrk-1 | Double mutant | 1 | 19.05% | ||
| daf-2;W01B11.3 | Double mutant | 1 | 151.72% | ||
| daf-2;W04G3.2 | Double mutant | 1 | -27.21% | ||
| daf-2;W06E11.4 | Double mutant | 1 | 100.00% | ||
| daf-2;wip-1 | Double mutant | 1 | 72.11% | ||
| daf-2;wwp-1 | Double mutant | 2 | 97.28% | ||
| daf-2;xbp-1 | Double mutant | 19 | -7.92% .. 156.99% | ||
| daf-2;Y39C12A.2 | Double mutant | 1 | -16.33% | ||
| daf-2;Y39G10AL.3 | Double mutant | 1 | 95.92% | ||
| daf-2;Y39G10AR.8 | Double mutant | 1 | 135.47% | ||
| daf-2;Y42G9A.4 | Double mutant | 1 | 74.15% | ||
| daf-2;Y47G6A.10 | Double mutant | 1 | 139.41% | ||
| daf-2;Y47G6A.18 | Double mutant | 1 | 85.71% | ||
| daf-2;Y48G1A.4 | Double mutant | 1 | 132.51% | ||
| daf-2;Y54G2A.31 | Double mutant | 1 | 92.52% | ||
| daf-2;Y55F3AM.3 | Double mutant | 1 | 89.12% | ||
| daf-2;Y57A10A.19 | Double mutant | 1 | 59.18% | ||
| daf-2;Y57G11C.13 | Double mutant | 1 | 55.78% | ||
| daf-2;Y59A8B.2 | Double mutant | 1 | -2.04% | ||
| daf-2;Y61A9LA.5 | Double mutant | 1 | -8.16% | ||
| daf-2;Y65B4A.3 | Double mutant | 1 | -23.13% | ||
| daf-2;Y77E11A.7 | Double mutant | 1 | 55.10% | ||
| daf-2;ZC250.3 | Double mutant | 1 | 52.38% | ||
| daf-2;ZK973.10 | Double mutant | 1 | 119.21% | ||
| daf-3;daf-7 | Double mutant | 6 | -40.73% .. 0.65% | ||
| daf-3;daf-9 | Double mutant | 1 | 79.43% | ||
| daf-3;mekk-3 | Double mutant | 2 | 37.97% .. 52.05% | ||
| daf-5;mekk-3 | Double mutant | 2 | 42.18% .. 43.44% | ||
| daf-7;nhr-8 | Double mutant | 1 | -2.41% | ||
| daf-9;eat-2 | Double mutant | 4 | -7.32% .. -5.61% | ||
| daf-9;eat-2;let-363 | Triple mutant | 1 | -46.95% .. 115.18% | [est.] | |
| daf-9;glp-1 | Double mutant | 3 | -71.0% .. -288.0% | [est.] | |
| daf-9;glp-1;nhr-80 | Triple mutant | 3 | -62.3% .. -252.71% | [est.] | |
| daf-9;pkc-2 | Double mutant | 1 | -35.12% .. 163.18% | [est.] | |
| daf-9;trpa-1 | Double mutant | 1 | -35.12% .. 163.18% | [est.] | |
| ddl-1;ddl-2 | Double mutant | 1 | 42.86% | ||
| ddl-1;fem-1;fer-15 | Triple mutant | 1 | -41.42% .. 137.65% | [est.] | |
| ddl-1;glp-1 | Double mutant | 2 | -43.74% .. -177.41% | [est.] | |
| ddl-1;hsb-1 | Double mutant | 2 | 47.89% .. 60.44% | ||
| ddl-1;hsf-1 | Double mutant | 1 | -20.00% | ||
| ddl-2;fem-1;fer-15 | Triple mutant | 2 | -44.9% .. -182.12% | [est.] | |
| ddl-2;glp-1 | Double mutant | 2 | -49.54% .. -200.94% | [est.] | |
| ddl-2;hsb-1 | Double mutant | 2 | 49.74% .. 63.16% | ||
| ddl-2;hsf-1 | Double mutant | 2 | -23.84% .. -14.44% | ||
| ddl-3;fem-1;fer-15 | Triple mutant | 1 | -42.29% .. 134.12% | [est.] | |
| ddl-3;glp-1 | Double mutant | 2 | -42.0% .. -170.35% | [est.] | |
| ddr-2;let-363 | Double mutant | 1 | -12.49% | ||
| ddr-2;pha-4 | Double mutant | 2 | 7.22% .. 36.75% | ||
| ddr-2;rab-10 | Double mutant | 4 | -6.04% .. 13.22% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
