| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| ddr-2;rsks-1 | Double mutant | 2 | 26.66% .. 35.51% | ||
| ddr-2;sams-1 | Double mutant | 5 | -4.06% .. 18.21% | ||
| dev-1;rrf3 | Double mutant | 1 | -18.25% | ||
| dod-10;fem-1;fer-15 | Triple mutant | 1 | -59.69% .. 63.53% | [est.] | |
| dod-11;fem-1;fer-15 | Triple mutant | 1 | -63.46% .. 48.24% | [est.] | |
| dod-12;fem-1;fer-15 | Triple mutant | 2 | -62.3% .. -252.71% | [est.] | |
| dod-13;fem-1;fer-15 | Triple mutant | 1 | -64.91% .. 42.35% | [est.] | |
| dod-15;fem-1;fer-15 | Triple mutant | 1 | -57.08% .. 74.12% | [est.] | |
| dod-16;fem-1;fer-15 | Triple mutant | 1 | -58.24% .. 69.41% | [est.] | |
| dod-17;fem-1;fer-15 | Triple mutant | 1 | -58.53% .. 68.24% | [est.] | |
| dod-17;rrf-3 | Double mutant | 1 | -41.71% .. 136.47% | [est.] | |
| dod-18;fem-1;fer-15 | Triple mutant | 2 | -50.99% .. -206.82% | [est.] | |
| dod-18;rrf-3 | Double mutant | 2 | -44.9% .. -182.12% | [est.] | |
| dod-19;rrf-3 | Double mutant | 1 | -44.32% .. 125.88% | [est.] | |
| dod-1;fem-1;fer-15 | Triple mutant | 2 | -68.68% .. -278.59% | [est.] | |
| dod-20;fem-1;fer-15 | Triple mutant | 1 | -63.75% .. 47.06% | [est.] | |
| dod-20;rrf-3 | Double mutant | 1 | -46.35% .. 117.65% | [est.] | |
| dod-21;fem-1;fer-15 | Triple mutant | 1 | -62.59% .. 51.76% | [est.] | |
| dod-21;rrf-3 | Double mutant | 1 | -46.93% .. 115.29% | [est.] | |
| dod-22;fem-1;fer-15 | Triple mutant | 1 | -64.91% .. 42.35% | [est.] | |
| dod-22;rrf-3 | Double mutant | 1 | -48.67% .. 108.24% | [est.] | |
| dod-23;rrf-3 | Double mutant | 2 | -53.02% .. -215.06% | [est.] | |
| dod-24;fem-1;fer-15 | Triple mutant | 2 | -64.91% .. -263.29% | [est.] | |
| dod-24;rrf-3 | Double mutant | 2 | -45.77% .. -185.65% | [est.] | |
| dod-2;fem-1;fer-15 | Triple mutant | 1 | -64.33% .. 44.71% | [est.] | |
| dod-3;fem-1;fer-15 | Triple mutant | 1 | -59.11% .. 65.88% | [est.] | |
| dod-4;fem-1;fer-15 | Triple mutant | 1 | -58.24% .. 69.41% | [est.] | |
| dod-6;fem-1;fer-15 | Triple mutant | 1 | -54.47% .. 84.71% | [est.] | |
| dod-7;fem-1;fer-15 | Triple mutant | 1 | -56.79% .. 75.29% | [est.] | |
| dod-9;fem-1;fer-15 | Triple mutant | 1 | -61.43% .. 56.47% | [est.] | |
| dpr-1;isp-1 | Double mutant | 1 | -14.36% .. 247.41% | [est.] | |
| dpy-5;ife-2;let-363;unc-13 | 4-mutant | 1 | 17.03% | ||
| dpy-5;let-363;unc-13 | Triple mutant | 1 | -1.10% | ||
| drl-1;flr-4 | Double mutant | 1 | 57.45% | ||
| drr-1;eat-2 | Double mutant | 2 | -16.47% .. -66.82% | [est.] | |
| drr-1;fem-1;fer-15 | Triple mutant | 1 | -37.35% .. 154.12% | [est.] | |
| drr-2;eat-2 | Double mutant | 3 | -35.61% .. -144.47% | [est.] | |
| drr-2;fem-1;fer-15 | Triple mutant | 2 | -34.16% .. -138.59% | [est.] | |
| eak-3;eak-7 | Double mutant | 2 | 8.20% .. 42.48% | ||
| eak-6;eak-7 | Double mutant | 2 | 36.97% .. 47.06% | ||
| eak-7;glp-1 | Double mutant | 2 | 120.77% .. 214.56% | ||
| eak-7;hsf-1 | Double mutant | 1 | -24.49% | ||
| eak-7;rle-1 | Double mutant | 2 | -12.08% .. 2.72% | ||
| eak-7;sdf-9 | Double mutant | 2 | 16.67% .. 44.52% | ||
| eak-7;sgk-1 | Double mutant | 2 | -27.89% .. -14.00% | ||
| eak-7;smk-1 | Double mutant | 1 | 9.85% | ||
| eat-2;egl-9 | Double mutant | 1 | 2.74% | ||
| eat-2;elt-3 | Double mutant | 1 | -4.07% | ||
| eat-2;emb-8 | Double mutant | 2 | 40.03% .. 49.28% | ||
| eat-2;F14B4.3 | Double mutant | 1 | 43.35% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
