| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| age-1;cst-1 | Caenorhabditis elegans | Double mutant | 1 | 29.45% | ||
| age-1;cup-4 | Caenorhabditis elegans | Double mutant | 2 | 6.43% .. 20.81% | ||
| age-1;daf-16 | Caenorhabditis elegans | Double mutant | 2 | -31.08% .. -22.84% | ||
| age-1;daf-16;drp1 | Caenorhabditis elegans | Triple mutant | 1 | -33.06% | ||
| age-1;daf-16;fer-15 | Caenorhabditis elegans | Triple mutant | 1 | 8.33% | ||
| age-1;daf-16;sqt-1 | Caenorhabditis elegans | Triple mutant | 1 | 16.67% | ||
| age-1;daf-18;fer-15 | Caenorhabditis elegans | Triple mutant | 1 | 0.00% | ||
| age-1;daf-2;fer-15 | Caenorhabditis elegans | Triple mutant | 2 | 96.00% .. 107.14% | ||
| age-1;drp-1 | Caenorhabditis elegans | Double mutant | 3 | 111.97% .. 149.24% | ||
| age-1;fer-15 | Caenorhabditis elegans | Double mutant | 5 | 24.00% .. 125.00% | ||
| age-1;fer-15;gro-1 | Caenorhabditis elegans | Triple mutant | 1 | 128.86% | ||
| age-1;hcf-1 | Caenorhabditis elegans | Double mutant | 2 | 82.76% .. 99.25% | ||
| age-1;hsf-1 | Caenorhabditis elegans | Double mutant | 2 | -20.26% .. -9.63% | ||
| age-1;ife-2 | Caenorhabditis elegans | Double mutant | 1 | 51.10% | ||
| age-1;nlp-7 | Caenorhabditis elegans | Double mutant | 2 | 9.94% .. 15.61% | ||
| age-1;oga-1 | Caenorhabditis elegans | Double mutant | 1 | 55.35% | ||
| age-1;ogt-1 | Caenorhabditis elegans | Double mutant | 1 | 0.00% | ||
| age-1;sgk-1 | Caenorhabditis elegans | Double mutant | 1 | 104.08% | ||
| age-1;shc-1 | Caenorhabditis elegans | Double mutant | 1 | 23.24% | ||
| age-1;skn-1 | Caenorhabditis elegans | Double mutant | 1 | 14.45% | ||
| age-1;sqt-1 | Caenorhabditis elegans | Double mutant | 1 | 50.00% | ||
| aha-1;clk-1 | Caenorhabditis elegans | Double mutant | 1 | 0.00% | ||
| aha-1;isp-1 | Caenorhabditis elegans | Double mutant | 2 | 13.92% | ||
| aha-1;mekk-3 | Caenorhabditis elegans | Double mutant | 2 | -26.26% .. -24.07% | ||
| aha-1;tpk-1 | Caenorhabditis elegans | Double mutant | 1 | -16.3% .. 239.53% | [est.] | |
| ahr-1;mekk-3 | Caenorhabditis elegans | Double mutant | 4 | -14.65% .. 19.91% | ||
| ain-1;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -40.14% | ||
| ain-1;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 111.56% | ||
| akt-1;akt-2 | Caenorhabditis elegans | Double mutant | 5 | 19.05% .. 220.67% | ||
| akt-1;akt-2;ets-4 | Caenorhabditis elegans | Triple mutant | 1 | -28.65% .. 189.41% | [est.] | |
| akt-1;akt-2;jnk-1 | Caenorhabditis elegans | Triple mutant | 1 | 160.40% | ||
| akt-1;akt-2;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | 63.04% | ||
| akt-1;akt-2;rrf-3;skn-1 | Caenorhabditis elegans | 4-mutant | 3 | -15.94% .. 47.83% | ||
| akt-1;akt-2;sgk-1 | Caenorhabditis elegans | Triple mutant | 1 | 54.42% | ||
| akt-1;asm-3 | Caenorhabditis elegans | Double mutant | 1 | -5.73% | ||
| akt-1;daf-16 | Caenorhabditis elegans | Double mutant | 2 | -39.04% .. -34.78% | ||
| akt-1;eak-3 | Caenorhabditis elegans | Double mutant | 2 | 0.64% .. 2.36% | ||
| akt-1;eak-4 | Caenorhabditis elegans | Double mutant | 2 | 1.92% .. 3.15% | ||
| akt-1;eak-6 | Caenorhabditis elegans | Double mutant | 2 | 0.79% .. 1.92% | ||
| akt-1;eak-7 | Caenorhabditis elegans | Double mutant | 2 | 80.85% .. 92.52% | ||
| akt-1;rict-1 | Caenorhabditis elegans | Double mutant | 2 | 61.71% .. 69.78% | ||
| akt-1;sdf-9 | Caenorhabditis elegans | Double mutant | 4 | 15.38% | ||
| akt-1;sgk-1 | Caenorhabditis elegans | Double mutant | 3 | -25.17% .. 20.69% | ||
| akt-1;trpa-1 | Caenorhabditis elegans | Double mutant | 1 | 35.53% | ||
| akt-1;utx-1 | Caenorhabditis elegans | Double mutant | 3 | 62.28% .. 86.76% | ||
| akt-2;eak-7 | Caenorhabditis elegans | Double mutant | 2 | 62.00% .. 74.83% | ||
| akt-2;trpa-1 | Caenorhabditis elegans | Double mutant | 1 | 58.31% | ||
| akt-2;utx-1 | Caenorhabditis elegans | Double mutant | 2 | 11.64% .. 34.72% | ||
| alg-2;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -32.65% | ||
| alg-2;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 29.25% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group