| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| C46G7.2;daf-16;rrf-3 | Triple mutant | 1 | -23.87% | ||
| C47D12.6;daf-16;daf-2 | Triple mutant | 1 | -36.45% | ||
| C47D12.6;daf-2 | Double mutant | 1 | 98.52% | ||
| C47D12.6;eat-2 | Double mutant | 1 | 24.63% | ||
| C48E7.2;daf-16;daf-2 | Triple mutant | 1 | -33.00% | ||
| C48E7.2;daf-2 | Double mutant | 1 | 114.78% | ||
| C48E7.2;eat-2 | Double mutant | 1 | 48.77% | ||
| C51E3.7;daf-16;rrf-3 | Triple mutant | 1 | -68.36% .. 28.35% | [est.] | |
| C56E6.1;daf-16;daf-2 | Triple mutant | 1 | -33.00% | ||
| C56E6.1;daf-2 | Double mutant | 1 | 131.03% | ||
| C56E6.1;eat-2 | Double mutant | 1 | 43.35% | ||
| cbp-1;clk-1 | Double mutant | 1 | -20.07% | ||
| cbp-1;daf-16 | Double mutant | 1 | -41.46% | ||
| cbp-1;daf-16;rrf3 | Triple mutant | 1 | -22.86% | ||
| cbp-1;daf-2 | Double mutant | 1 | 21.41% | ||
| cbp-1;eat-2 | Double mutant | 1 | -27.81% | ||
| cbp-1;glp-1 | Double mutant | 1 | -4.98% | ||
| cbp-1;mev-1 | Double mutant | 1 | -25.85% | ||
| cbp-1;rrf3 | Double mutant | 5 | -28.50% .. -16.45% | ||
| cchl-1;daf-16 | Double mutant | 1 | -49.25% .. 105.88% | [est.] | |
| cchl-1;daf-2 | Double mutant | 1 | 13.4% .. 360.0% | [est.] | |
| cchl-1;fem-1;fer-15 | Triple mutant | 1 | -48.09% .. 110.59% | [est.] | |
| cco-1;cep-1 | Double mutant | 1 | 69.81% | ||
| cco-1;daf-16 | Double mutant | 1 | -57.66% .. 71.76% | [est.] | |
| cco-1;daf-16;skn-1 | Triple mutant | 2 | 7.28% .. 23.18% | ||
| cco-1;daf-2 | Double mutant | 1 | 40.08% .. 468.24% | [est.] | |
| cco-1;fem-1;fer-15 | Triple mutant | 1 | -44.9% .. 123.53% | [est.] | |
| cco-1;hif-1 | Double mutant | 1 | 43.88% | ||
| cco-1;kin-29 | Double mutant | 1 | 44.19% | ||
| cco-1;mml-1 | Double mutant | 1 | 51.16% | ||
| cco-1;nhr-49 | Double mutant | 2 | -16.57% .. 14.12% | ||
| cco-1;nhr-62 | Double mutant | 2 | 92.42% .. 109.40% | ||
| cco-1;par-4 | Double mutant | 1 | 64.53% | ||
| cco-1;sad-1 | Double mutant | 1 | 22.09% | ||
| cco-2;daf-16 | Double mutant | 1 | -28.07% .. 191.76% | [est.] | |
| cco-2;daf-2 | Double mutant | 1 | 54.0% .. 524.71% | [est.] | |
| cco-2;fem-1;fer-15 | Triple mutant | 1 | -20.82% .. 221.18% | [est.] | |
| ccr-4;daf-16;daf-2 | Triple mutant | 1 | -42.86% | ||
| ccr-4;daf-2 | Double mutant | 1 | 62.59% | ||
| CD4.4;daf-16;daf-2 | Triple mutant | 1 | -48.98% | ||
| CD4.4;daf-2 | Double mutant | 1 | 38.78% | ||
| cdk-2;daf-16 | Double mutant | 3 | -5.46% .. 3.63% | ||
| cdk-2;glp-1 | Double mutant | 3 | 19.69% .. 25.40% | ||
| cdk-2;kri-1 | Double mutant | 3 | 1.06% .. 12.44% | ||
| cdk-2;skn-1 | Double mutant | 3 | -14.87% .. -13.24% | ||
| cdr-5;rrf-3 | Double mutant | 1 | -26.33% .. 198.82% | [est.] | |
| Ce-atg7;eat-2 | Double mutant | 1 | -8.14% | ||
| ced-13;ced-4;isp-1 | Triple mutant | 3 | 25.27% .. 30.36% | ||
| ced-13;ced-4;nuo-6 | Triple mutant | 3 | 24.38% .. 34.01% | ||
| ced-13;isp-1 | Double mutant | 3 | 12.64% .. 36.05% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
