| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| ced-13;nuo-6 | Double mutant | 3 | 32.25% .. 41.85% | ||
| ced-3;unc-51 | Double mutant | 1 | -26.91% .. 196.47% | [est.] | |
| ced-4;cyc-2.1 | Double mutant | 1 | -9.77% .. 266.0% | [est.] | |
| ced-4;egl-1;isp-1 | Triple mutant | 3 | 30.71% .. 34.28% | ||
| ced-4;egl-1;nuo-6 | Triple mutant | 3 | 31.90% .. 40.04% | ||
| ced-4;isp-1 | Double mutant | 5 | 25.46% .. 43.92% | ||
| ced-4;nuo-6 | Double mutant | 9 | 25.24% .. 60.88% | ||
| ceh-18;isp-1 | Double mutant | 1 | -36.75% .. 156.59% | [est.] | |
| ceh-18;tpk-1 | Double mutant | 1 | -12.91% .. 253.29% | [est.] | |
| ceh-23;ctb-1;isp-1 | Triple mutant | 18 | 9.36% .. 52.07% | ||
| ceh-23;isp-1 | Double mutant | 14 | -4.59% .. 42.90% | ||
| ceh-24;isp-1 | Double mutant | 1 | -20.33% .. 223.18% | [est.] | |
| cel-1;daf-16;daf-2 | Triple mutant | 1 | -43.54% | ||
| cel-1;daf-2 | Double mutant | 1 | -39.46% | ||
| cep-1;clk-1 | Double mutant | 5 | -15.06% .. 18.18% | ||
| cep-1;cyc-2.1 | Double mutant | 1 | 2.81% .. 317.06% | [est.] | |
| cep-1;frh-1 | Double mutant | 1 | 33.33% | ||
| cep-1;ftn-1;ftn-2 | Triple mutant | 2 | 1.46% .. 10.32% | ||
| cep-1;ftn-1;ftn-2;isp-1 | 4-mutant | 2 | 8.06% .. 35.04% | ||
| cep-1;ftn-1;ftn-2;mev-1 | 4-mutant | 2 | -16.22% .. -11.60% | ||
| cep-1;gas-1 | Double mutant | 5 | -19.88% .. 22.21% | ||
| cep-1;isp-1 | Double mutant | 6 | 9.62% .. 82.39% | ||
| cep-1;mev-1 | Double mutant | 12 | -16.28% .. 16.65% | ||
| cep-1;nuo-6 | Double mutant | 1 | 3.35% | ||
| chc-1;daf-16 | Double mutant | 1 | -37.93% | ||
| chc-1;daf-2 | Double mutant | 1 | 86.70% | ||
| chc-1;eat-2 | Double mutant | 1 | 18.72% | ||
| chc-1;ifg-1 | Double mutant | 2 | 4.87% .. 8.87% | ||
| chc-1;isp-1 | Double mutant | 1 | 45.81% | ||
| chc-1;rsks-1 | Double mutant | 1 | 13.30% | ||
| cit-1.2;daf-16;daf-2 | Triple mutant | 1 | -33.33% | ||
| cit-1.2;daf-2 | Double mutant | 1 | 88.44% | ||
| cku-70;daf-16 | Double mutant | 1 | -9.22% | ||
| cku-70;daf-16;daf-2 | Triple mutant | 1 | 2.84% | ||
| cku-70;daf-2 | Double mutant | 1 | 131.21% | ||
| cku-70;daf-2;glp-4 | Triple mutant | 1 | 162.41% | ||
| cku-70;rrf-3 | Double mutant | 1 | 9.93% | ||
| cku-80;daf-2 | Double mutant | 1 | 59.57% | ||
| cku-80;daf-2;glp-4 | Triple mutant | 1 | 134.75% | ||
| cku-80;rrf-3 | Double mutant | 1 | 4.26% | ||
| clk-10;daf-2 | Double mutant | 1 | 80.76% | ||
| clk-1;clk-2 | Double mutant | 6 | 37.73% .. 89.93% | ||
| clk-1;clk-3 | Double mutant | 6 | 10.56% .. 191.95% | ||
| clk-1;cup-4 | Double mutant | 2 | 26.74% .. 33.54% | ||
| clk-1;daf-16 | Double mutant | 3 | -15.30% .. 36.24% | ||
| clk-1;daf-2 | Double mutant | 5 | 60.43% .. 477.65% | ||
| clk-1;drp-1 | Double mutant | 1 | 76.58% | ||
| clk-1;eat-2 | Double mutant | 2 | 21.00% .. 39.59% | ||
| clk-1;egl-1 | Double mutant | 1 | 32.03% | ||
| clk-1;egl-9 | Double mutant | 1 | 31.94% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
