| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| clk-1;hif-1 | Double mutant | 3 | -4.91% .. 54.70% | ||
| clk-1;ife-2 | Double mutant | 1 | 63.19% | ||
| clk-1;ifg-1 | Double mutant | 1 | -30.1% .. 183.53% | [est.] | |
| clk-1;mekk-3 | Double mutant | 2 | 49.66% .. 106.76% | ||
| clk-1;nlp-7 | Double mutant | 2 | 28.49% .. 34.16% | ||
| clk-1;prmt-1 | Double mutant | 1 | -43.16% .. 130.59% | [est.] | |
| clk-1;rsks-1 | Double mutant | 1 | -35.9% .. 160.0% | [est.] | |
| clk-1;skn-1 | Double mutant | 2 | 12.79% .. 18.63% | ||
| clk-1;smk-1 | Double mutant | 1 | -9.29% | ||
| clk-1;sod-2 | Double mutant | 1 | 146.89% | ||
| clk-1;unc-51 | Double mutant | 1 | -23.14% .. 211.76% | [est.] | |
| clk-1;vhl-1 | Double mutant | 2 | 33.33% .. 41.10% | ||
| clk-2;clk-3 | Double mutant | 3 | 27.95% .. 49.66% | ||
| clk-2;daf-2 | Double mutant | 1 | 268.35% | ||
| clk-2;gro-1 | Double mutant | 2 | -17.45% | ||
| clk-3;daf-16 | Double mutant | 1 | 28.86% | ||
| clk-3;daf-2 | Double mutant | 1 | 123.09% | ||
| clk-3;gro-1 | Double mutant | 3 | -9.32% .. 6.71% | ||
| clk-4;daf-2 | Double mutant | 1 | 123.09% | ||
| clk-5;daf-2 | Double mutant | 1 | 85.18% | ||
| clk-7;daf-2 | Double mutant | 1 | 139.97% | ||
| clk-8;daf-2 | Double mutant | 1 | 130.73% | ||
| clk-9;daf-2 | Double mutant | 1 | 136.75% | ||
| cmk-1;trpa-1 | Double mutant | 2 | 48.86% .. 58.18% | ||
| cnc-2;rrf-3 | Double mutant | 2 | -24.01% .. -97.41% | [est.] | |
| cnc-7;rrf-3 | Double mutant | 2 | -28.07% .. -113.88% | [est.] | |
| col-127;daf-2 | Double mutant | 1 | -24.88% .. 204.71% | [est.] | |
| col-13;daf-2 | Double mutant | 1 | -31.26% .. 178.82% | [est.] | |
| col-144;daf-2 | Double mutant | 2 | 60.00% .. 130.71% | ||
| col-84;daf-16;daf-2 | Triple mutant | 1 | -40.82% | ||
| col-84;daf-2 | Double mutant | 1 | 65.99% | ||
| cst-1;daf-16 | Double mutant | 1 | -14.72% | ||
| cst-1;daf-2 | Double mutant | 1 | 7.25% | ||
| ctb-1;drp-1;isp-1 | Triple mutant | 1 | 78.98% | ||
| ctb-1;isp-1 | Double mutant | 8 | 27.21% .. 67.35% | ||
| ctl-1;ctl-2;ctl-3 | Triple mutant | 3 | -55.92% .. -226.82% | [est.] | |
| ctl-1;ctl-2;ctl-3;sod-1 | 4-mutant | 2 | -42.0% .. -170.35% | [est.] | |
| ctl-1;ctl-2;ctl-3;sod-2 | 4-mutant | 2 | -39.68% .. -160.94% | [est.] | |
| ctl-1;ctl-2;daf-2;fem-1;fer-15 | 5-mutant | 1 | -28.36% .. 190.59% | [est.] | |
| ctl-1;daf-2;fem-1;fer-15 | 4-mutant | 2 | -31.26% .. -126.82% | [est.] | |
| ctl-1;daf-2;rrf-3 | Triple mutant | 1 | -6.03% .. 281.18% | [est.] | |
| ctl-2;daf-2;fem-1;fer-15 | 4-mutant | 3 | -60.56% .. -245.65% | [est.] | |
| ctl-2;daf-2;rrf-3 | Triple mutant | 1 | -2.84% .. 294.12% | [est.] | |
| ctl-2;fem-1;fer-15 | Triple mutant | 1 | -60.85% .. 58.82% | [est.] | |
| cua-1;daf-16;daf-2 | Triple mutant | 1 | -35.37% | ||
| cua-1;daf-2 | Double mutant | 1 | -25.17% | ||
| cul-1;daf-2 | Double mutant | 10 | 15.59% | ||
| cul-1;eat-2 | Double mutant | 2 | -26.91% .. -109.18% | [est.] | |
| cul-1;glp-1 | Double mutant | 3 | 21.51% .. 22.58% | ||
| cul-2;daf-2 | Double mutant | 1 | 48.39% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
